Tandutinib (MLN518)

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FLT3 Inhibitor

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Catalog No. A10887

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Tandutinib 25mg A10887-25

Regular Price: $40.00

Special Price: $32.00

Tandutinib 50mg A10887-50

Regular Price: $50.00

Special Price: $40.00

Tandutinib 100mg A10887-100

Regular Price: $80.00

Special Price: $64.00

Tandutinib 200mg A10887-200

Regular Price: $140.00

Special Price: $112.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Tandutinib (MLN518) inhibits the autophosphorylation of FLT3, c-KIT and PDGF receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.

Tandutinib (MLN518)

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Chemical Information

Catalog Num A10887
Actions Inhibitor
M. Wt 562.7
Formula C31H42N6O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 387867-13-2
Synonyms MLN-518, CT53518
SMILES code CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5
Chemical Name 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide; (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide

Biological Activity

Description
Tandutinib (MLN518) inhibits the autophosphorylation of FLT3, c-KIT and PDGF receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.
Targets
Target Value
c-KitIC50: 0.17μM
PDGFRβIC50: 0.20μM
FLT3IC50: 0.22μM
CSF-1RIC50: 3.43μM
SrcIC50: 30μM
AblIC50: >30μM
PKCIC50: >30μM
PKAIC50: >30μM
MEK1IC50: >30μM
MKK4IC50: >30μM
MKK6IC50: >30μM
ERK2IC50: >30μM
p38IC50: >30μM
KDRIC50: >30μM
EGFRIC50: >30μM
FGFRIC50: >30μM
Insulin ReceptorIC50: >30μM

Solubility

Solubility (25°C) * In vitro DMSO 5 mg/mL (8.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (10.66 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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