TSU-68 (Orantinib, SU6668)

Name: TSU-68 (Orantinib, SU6668)
Brand: Adooq Bioscience
SKU: A10953
Rating: 5 (2 reviews)

Catalog No.: A10953

PDFGRβ inhibitor

Adooq's TSU-68 (Orantinib, SU6668) has been cited by 2 publications

Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.

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TSU-68 (Orantinib, SU6668) 252916-29-3 PDFGRβ inhibitor

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Grouped product items
Size	Price	Stock
1mg	$20.00	In stock
5mg	$40.00	In stock
10mg	$65.00	In stock
25mg	$145.00	In stock
50mg	$285.00	In stock
100mg	$455.00	In stock
*10mM 1mL in DMSO**	$45.00	In stock
Bulk Size	Bulk Discount

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Data Sheet SDS

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Adooq Products cited in reputable paper

Adooq's TSU-68 (Orantinib, SU6668) has been cited by 2 publications

Ayaka Kojima, .et al. , Xenobiotica, 2022, Jul;52(7):669-675 PMID: 36251932
Aaron Y. Lai, .et al. , Brain, 2015, Apr;138(Pt 4):1046-58 PMID: 25688079

Biological Activity

Description

Targets

Target	Value

Product Information

Catalog Num	A10953
Formula	C18H18N2O3
Molecular Weight	310.4
CAS Number	252916-29-3
SMILES	CC1=C(NC(=C1CCC(=O)O)C)/C=C\2/C3=CC=CC=C3NC2=O
Synonyms	TSU68
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	55 mg/mL (177.22 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.22 mL	161.08 mL	322.16 mL
0.5 mM	6.44 mL	32.22 mL	64.43 mL
1 mM	3.22 mL	16.11 mL	32.22 mL
5 mM	0.64 mL	3.22 mL	6.44 mL

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂