TSU-68 (Orantinib, SU6668)

Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.
Grouped product items
Product Name Price Stock Qty
TSU-68 5mg
$50.00
In stock
TSU-68 10mg
$90.00
In stock
TSU-68 50mg
$350.00
In stock
TSU-68 100mg
$460.00
In stock
TSU-68 (SU6668) 10mM * 1mL in DMSO
$90.00
In stock
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Adooq Products cited in reputable paper
Adooq's TSU-68 (Orantinib, SU6668) has been cited by 2 publications
  • Ayaka Kojima, .et al. , Xenobiotica, 2022, Jul;52(7):669-675 PMID: 36251932
  • Aaron Y. Lai, .et al. , Brain, 2015, Apr;138(Pt 4):1046-58 PMID: 25688079
  • Biological Activity
    Discription Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.
    Targets
    Target Value
    Product Information
    Catalog Num A10953
    Formula C18H18N2O3
    Molecular Weight 310.4
    CAS Number 252916-29-3
    SMILES CC1=C(NC(=C1CCC(=O)O)C)/C=C\2/C3=CC=CC=C3NC2=O
    Synonyms TSU68
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 55 mg/mL (177.22 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 32.22 mL 161.08 mL 322.16 mL
    0.5 mM 6.44 mL 32.22 mL 64.43 mL
    1 mM 3.22 mL 16.11 mL 32.22 mL
    5 mM 0.64 mL 3.22 mL 6.44 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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