ABT-737 ON SALE Bcl-2 Inhibitor

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Catalog No. A10255

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
ABT-737 5mg A10255-5

Regular Price: $60.00

Special Price: $51.00

ABT-737 10mg A10255-10

Regular Price: $100.00

Special Price: $85.00

ABT-737 50mg A10255-50

Regular Price: $300.00

Special Price: $255.00

ABT-737 100mg A10255-100

Regular Price: $500.00

Special Price: $425.00

ABT-737 10mM * 1mL in DMSO A10255-10mM-D

Regular Price: $157.00

Special Price: $133.45

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).

ABT-737

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Chemical Information

Catalog Num A10255
Actions Inhibitor
M. Wt 813.4
Formula C42H45ClN6O5S2
Solubility DMSO>163mg/mL Water<1mg/mL Ethanol<1mg/mL
Purity >98%
Storage at -20°C 2 years
CAS No. 852808-04-9
Synonyms N/A
SMILES code CN(C)CC[[email protected]](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]
Chemical Name 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide

Biological Activity

Description
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).
Targets
Target Value
Bcl-2EC50:30.3nM
Bcl-xLEC50:78.7nM
Bcl-wEC50:197.8nM
Bcl-BEC50:1.82 uM
Bfl-1EC50>10 uM
Mcl-1EC50>10 uM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (122.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

View Related Products By Research Topics

Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10255 ABT-737 <1 mg/mL 163 mg/mL <1 mg/mL
A10022 ABT-263 (Navitoclax) <1 mg/mL 195 mg/mL <1 mg/mL
A10665 Obatoclax mesylate (GX15-070) <1 mg/mL 83 mg/mL <1 mg/mL
A10955 TW-37 <1 mg/mL 115 mg/mL 4 mg/mL
A10984 VX-765 <1 mg/mL 102 mg/mL 102 mg/mL
A11090 PAC-1 <1 mg/mL 78 mg/mL 16 mg/mL
A10491 JNJ 26854165 <1 mg/mL 66 mg/mL 2 mg/mL
A11931 RITA (NSC 652287) <1 mg/mL 115 mg/mL 4 mg/mL
A10522 Lenalidomide (CC-5013) <1 mg/mL 52 mg/mL <1 mg/mL
A10743 Pomalidomide (CC-4047) <1 mg/mL 55 mg/mL <1 mg/mL
A11163 AT-406 <1 mg/mL 112 mg/mL 112 mg/mL
A11002 YM155 89 mg/mL 55 mg/mL 6 mg/mL
A10935 Tipifarnib (Zarnestra) <1 mg/mL 83 mg/mL <1 mg/mL
A10657 Nutlin-3 <1 mg/mL 116 mg/mL 116 mg/mL
A11635 Cyclophosphamide monohydrate 20 mg/mL 56 mg/mL <1 mg/mL

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