Autophagy Signaling

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  1. SMER28

    Catalog No. A15867
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    Autophagy Activator
    SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells. Learn More
  2. Chloroquine Phosphate

    Catalog No. A16445
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    Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Learn More
  3. Hydroxychloroquine Sulfate

    Catalog No. A14208
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    Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9. Learn More
  4. Spautin-1

    Catalog No. A12942
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    Autophagy Inhibitor
    Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03μM. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM. Learn More
  5. SBC-115076

    Catalog No. A15769
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    PCSK9 antagonist
    SBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases. Learn More
  6. SBI-0206965

    Catalog No. A15795
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    ULK1 inhibitor
    SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 . Learn More
  7. MRT68921

    Catalog No. A15880
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    Autophagy ULK1/2 inhibitor
    MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. Learn More
  8. Lys05

    Catalog No. A16358
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    Autophagy inhibitor
    Lys05 is a potent lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Learn More
  9. Scutellarein

    Catalog No. A12234
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    Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz, has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases. Learn More
  10. Azithromycin Dihydrate

    Catalog No. A16421
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    Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. Learn More
  11. Flubendazole (Flutelmium)

    Catalog No. A11656
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    autophagy inducer
    Flubendazole is an anthelmintic used for protection against internal parasites and worms in dogs and cats. Learn More
  12. STF-62247

    Catalog No. A10866
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    Autophagy Inducer
    STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). Learn More
  13. Resveratrol

    Catalog No. A10785
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    Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Learn More
  14. GNE-7915

    Catalog No. A13748
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    LRRK2 inhibitor
    GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2). Learn More
  15. LRRK2-IN-1

    Catalog No. A11477
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    LRRK2 inhibitor
    LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively. Learn More
  16. PF-06447475

    Catalog No. A15504
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    LRRK2 inhibitor
    PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC50 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively. Learn More
  17. CZC54252 hydrochloride

    Catalog No. A15510
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    LRRK2 inhibitor
    CZC-54252 is a potent inhibitor of LRRK2 with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2 respectively. Learn More
  18. CZC-25146 hydrochloride

    Catalog No. A13448
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    LRRK2 inhibitor
    CZC-25146 is a potent and selective LRRK2 inhibitor. CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency. Learn More
  19. TAE684

    Catalog No. A10662
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    ALK Inhibitor
    TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant). Learn More
  20. GNE0877

    Catalog No. A13969
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    LRRK2 inhibitor
    GNE-0877 is a highly potent and selective LRRK2 inhibitor. Learn More
  21. JH-II-127

    Catalog No. A15777
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    LRRK2 inhibitor
    JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. Learn More
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    CZC-25146

    Catalog No. A17125
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    LRRK2 inhibitor
    CZC-25146 is a potent LRRK2 inhibitor. Learn More
  22. GSK2578215A

    Catalog No. A12798
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    LRRK2 kinase inhibitor
    GSK2578215A is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1 nM respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Learn More
  23. GNE 9605

    Catalog No. A14149
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    LRRK2 inhibitor
    GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively. Learn More
  24. HG-10-102-01

    Catalog No. A12919
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    LRRK2 Inhibitor III
    HG-10-102-01 is a brain penetrant, potent and selective inhibitor of wild-type LRRK2. Learn More
  25. SCH-527123 (Navarixin)

    Catalog No. A11555
    CXCR1/CXCR2 antagonist
    SCH527123 is a potent and selective antagonist of the human CXCR1 and CXCR2 receptors with IC50 of 42 nM and 3 nM, respectively. Learn More
  26. SRT3109

    Catalog No. A11097
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    CXCR2 ligand
    SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions. Learn More
  27. AZD-5069

    Catalog No. A15941
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    CXCR2 antagonist
    AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD. Learn More
  28. AMD 070

    Catalog No. A11315
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    CXCR4 antagonist
    AMD 070 is a CXCR4 chemokine receptor antagonist. Learn More
  29. AMD 3465 Hexahydrobromide

    Catalog No. A11953
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    CXCR4 antagonist
    AMD 3465 is a potent, selective CXCR4 antagonist. Learn More
  30. Plerixafor 8HCl (DB06809)

    Catalog No. A10913
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    CXCR4 antagonist
    Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation. Learn More
  31. SB265610

    Catalog No. A14195
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    CXCR2 antagonist
    SB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site. It does not bind to the related CXCR1 receptor.1 It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury. Learn More
  32. WZ811

    Catalog No. A12588
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    CXCR4 antagonist
    WZ811 is a C-X-C chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM). Learn More
  33. SRT3190

    Catalog No. A11577
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    SIRT1 activator
    SRT3190 is a potent CXCR2 ligand. Learn More
  34. MSX-122

    Catalog No. A12596
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    CXCR4 Inhibitor
    MSX-122 is an orally bioavailable inhibitor of CXCR4 (IC50 = ~10 nM) with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration. Learn More
  35. Reparixin

    Catalog No. A12383
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    CXCL8/CXCR1/2 Inhibitor
    Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM). Learn More
  36. AMD3100 (Plerixafor)

    Catalog No. A13074
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    CXCR4 antagonist
    Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation. Learn More
  37. AMD-070 HCl

    Catalog No. A14997
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    CXCR4 antagonist
    AMD-070 hydrochloride is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, inhibit the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. Learn More
  38. SCH 563705

    Catalog No. A15234
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    CXCR2/CXCR1 antagonist
    SCH 563705 is a potent dual CXCR2(IC50= 1.3 nM)/CXCR1(IC50= 7.3 nM) antagonist. Learn More
  39. SB225002

    Catalog No. A14209
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    CXCR2 antagonist
    SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested. Learn More
  40. ATI-2341

    Catalog No. A16351
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    CXCR4 agonist
    ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4) (EC50 = 194 nM, is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. Learn More
  41. Reparixin L-lysine salt

    Catalog No. A15219
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    CXCL8 receptor inhibitor
    Reparixin L-lysine salt is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation,which has been shown to attenuate inflammatory responses in various injury models. Learn More
  42. UNBS5162

    Catalog No. A15439
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    CXCL chemokines antagonist
    UNBS5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers; the mean antiproliferative activity IC50 value is 17.9 uM for 9 cancer cell lines; hydrolysis product of UNBS3157. Learn More

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