Autophagy Signaling

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  1. 3-Methyladenine

    Catalog No. A11151
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    Autophagy/PI3K Inhibitor
    3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase). Learn More
  2. Lys01 trihydrochloride

    Catalog No. A21702
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    lysosomal autophagy inhibitor
    Lys01 trihydrochloride (Lys05) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. Learn More
  3. QX77

    Catalog No. A13379
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    autophagy (CMA) activator
    QX77 is a chaperone-mediated autophagy (CMA) activator. Learn More
  4. EN6

    Catalog No. A18524
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    Autophagy activator
    EN6 is a novel covalent autophagy activator, targeting cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase, which activates mTORC1 via the Rag guanosine triphosphatases. Learn More
  5. Aumitin

    Catalog No. A18838
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    Autophagy inhibitor
    Aumitin is an autophagy inhibitor, targeting mitochondrial complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively. Learn More
  6. EACC

    Catalog No. A19062
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    Autophagy inhibitor
    EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. Learn More
  7. IITZ-01

    Catalog No. A20192
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    Lysosomotropic autophagy inhibitor
    IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. Learn More
  8. ALLO-1

    Catalog No. A18670
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    autophagy receptor
    ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. Learn More
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    Autophinib

    Catalog No. A17241
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    Autophagy inhibitor
    Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34. Learn More
  9. ROC-325

    Catalog No. A17031
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    Autophagy inhibitor
    ROC-325 is an autophagy inhibitor. ROC-325 exhibited superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in 12 different cancer cell lines with diverse genetic backgrounds. Learn More
  10. Monensin sodium

    Catalog No. A10603
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    autophagy inhibitor
    Monensin sodium is an ionophore and inhibitor of autophagy commercially used in livestock feed. It inhibits autophagy, interfering with the fusion of the autophagosome and the lysosome. Learn More
  11. PIK-III

    Catalog No. A15868
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    Autophagy Inhibitor
    PIK-III is a selective inhibitor of ?VPS34 enzymatic activity. Learn More
  12. SMER28

    Catalog No. A15867
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    Autophagy Activator
    SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells. Learn More
  13. MRT68921

    Catalog No. A15880
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    Autophagy ULK1/2 inhibitor
    MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. Learn More
  14. Scutellarein

    Catalog No. A12234
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    Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz, has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases. Learn More
  15. Lys05

    Catalog No. A16358
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    Autophagy inhibitor
    Lys05 is a potent lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Learn More
  16. Azithromycin Dihydrate

    Catalog No. A16421
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    Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. Learn More
  17. Chloroquine Phosphate

    Catalog No. A16445
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    Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Learn More
  18. SBI-0206965

    Catalog No. A15795
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    ULK1 inhibitor
    SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 . Learn More
  19. SBC-115076

    Catalog No. A15769
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    PCSK9 antagonist
    SBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases. Learn More
  20. Spautin-1

    Catalog No. A12942
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    Autophagy Inhibitor
    Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03μM. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM. Learn More
  21. Hydroxychloroquine Sulfate

    Catalog No. A14208
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    Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9. Learn More
  22. Flubendazole (Flutelmium)

    Catalog No. A11656
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    autophagy inducer
    Flubendazole is an anthelmintic used for protection against internal parasites and worms in dogs and cats. Learn More
  23. STF-62247

    Catalog No. A10866
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    Autophagy Inducer
    STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). Learn More
  24. Resveratrol

    Catalog No. A10785
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    Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Learn More
  25. CZC54252 hydrochloride

    Catalog No. A15510
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    LRRK2 inhibitor
    CZC-54252 is a potent inhibitor of LRRK2 with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2 respectively. Learn More
  26. PF-06447475

    Catalog No. A15504
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    LRRK2 inhibitor
    PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC50 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively. Learn More
  27. LRRK2-IN-1

    Catalog No. A11477
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    LRRK2 inhibitor
    LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively. Learn More
  28. CZC-25146 hydrochloride

    Catalog No. A13448
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    LRRK2 inhibitor
    CZC-25146 is a potent and selective LRRK2 inhibitor. CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency. Learn More
  29. GNE-7915

    Catalog No. A13748
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    LRRK2 inhibitor
    GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2). Learn More
  30. TAE684

    Catalog No. A10662
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    ALK Inhibitor
    TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant). Learn More
  31. PFE-360 (PF-06685360)

    Catalog No. A18816
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    LRRK2 inhibitor
    PFE-360, also known asd PF-06685360, is a potent and selective inhibitor of LRRK2 kinase. Learn More
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    PF-06371900

    Catalog No. A17221
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    LRRK2 inhibitor
    PF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor. Learn More
    • New

    CZC-25146

    Catalog No. A17125
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    LRRK2 inhibitor
    CZC-25146 is a potent LRRK2 inhibitor. Learn More
  32. JH-II-127

    Catalog No. A15777
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    LRRK2 inhibitor
    JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. Learn More
  33. GNE 9605

    Catalog No. A14149
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    LRRK2 inhibitor
    GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively. Learn More
  34. GNE0877

    Catalog No. A13969
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    LRRK2 inhibitor
    GNE-0877 is a highly potent and selective LRRK2 inhibitor. Learn More
  35. HG-10-102-01

    Catalog No. A12919
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    LRRK2 Inhibitor III
    HG-10-102-01 is a brain penetrant, potent and selective inhibitor of wild-type LRRK2. Learn More
  36. GSK2578215A

    Catalog No. A12798
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    LRRK2 kinase inhibitor
    GSK2578215A is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1 nM respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Learn More
  37. NSC-23026

    Catalog No. A17151
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    CXCR4 receptor modulator
    NSC-23026 is a CXCR4 receptor modulator. Learn More
  38. MSX-130

    Catalog No. A17150
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    CXCR4 Antagonist
    MSX-130 is CXCR4 antagonist. Learn More
  39. USL311

    Catalog No. A18778
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    CXCR4 receptor antagonist
    USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. Learn More
  40. Kynurenic acid

    Catalog No. A16581
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    GPR35/CXCR8 agonist
    Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. Learn More
  41. PS372424

    Catalog No. A19421
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    Human CXCR3 agonist
    PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM. Learn More
  42. CXCR2-IN-1

    Catalog No. A12649
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    CXCR2 antagonists
    CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3. Learn More
  43. GPR35 agonist 1

    Catalog No. A12462
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    GPR35/CXCR8 agonist
    GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good druggability. Learn More
  44. Kynurenic acid sodium

    Catalog No. A20000
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    GPR35/CXCR8 agonist
    Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. Learn More
  45. AMG 487

    Catalog No. A21162
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    CXCR3 antagonist
    AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. Learn More
  46. SCH 546738

    Catalog No. A21554
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    CXCR3 antagonist
    SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. Learn More
  47. AMG 487 S-enantiomer

    Catalog No. A21874
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    CXCR3 antagonist
    AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3. Learn More

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