AEE788

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EGFR inhibitor

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Catalog No. A10043

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AEE788 5mg A10043-5

Regular Price: $90.00

Special Price: $76.50

AEE788 10mg A10043-10

Regular Price: $160.00

Special Price: $136.00

AEE788 25mg A10043-25

Regular Price: $320.00

Special Price: $272.00

AEE788 50mg A10043-50

Regular Price: $550.00

Special Price: $467.50

AEE788 10mM * 1mL in DMSO A10043-10mM-D

Regular Price: $165.00

Special Price: $140.25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2.

AEE788

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Chemical Information

Catalog Num A10043
Actions Inhibitor
M. Wt 440.6
Formula C27H32N6
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 497839-62-0
Synonyms AEE-788, NVP-AEE788
SMILES code CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4N[C@H](C)C5=CC=CC=C5
Chemical Name 6-[4-[(4-Ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Biological Activity

Description
AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2.
Targets
Target Value
EGFRIC50: 2nM
HER2/ErbB2IC50: 6nM
c-AblIC50: 52nM
FLT1IC50: 59nM
c-FmsIC50: 60nM
c-SrcIC50: 61nM
KDRIC50: 77nM
HER4/ErbB4IC50: 160nM
PDGFRβIC50: 320nM
FLT4IC50: 330nM
FLT3IC50: 730nM
RETIC50: 740nM
c-KitIC50: 790nM
TekIC50: 2.1μM
C-Raf-1IC50: 2.8μM
c-MetIC50: 2.9μM
CDK1/CyclinBIC50: 8.0μM
IGF-1RIC50: >10μM
Insulin ReceptorIC50: >10μM
PKCαIC50: >10μM
PKAIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 88 mg/mL (199.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10043 AEE788 <1 mg/mL 88 mg/mL <1 mg/mL
A11022 AG-1478 (Tyrphostin AG-1478) <1 mg/mL 25 mg/mL 13 mg/mL
A10047 AG 490 <1 mg/mL 59 mg/mL 6 mg/mL
A11027 ARRY-380 <1 mg/mL 114 mg/mL <1 mg/mL
A11158 ARRY334543 <1 mg/mL 6 mg/mL <1 mg/mL
A11155 AST-1306 <1 mg/mL 124 mg/mL <1 mg/mL
A10116 AZD8931 <1 mg/mL 40 mg/mL <1 mg/mL
A11334 BIBX 1382 50 mg/mL 50 mg/mL N/A
A11209 Lenalidomide (CC-5013) <1 mg/mL 113 mg/mL 20 mg/mL
A10743 BMS 599626 (AC480) <1 mg/mL 55 mg/mL <1 mg/mL
A10211 Canertinib (CI-1033) <1 mg/mL 2 mg/mL 9 mg/mL
A10210 Chrysophanic acid (Chrysophanol) <1 mg/mL <1 mg/mL <1 mg/mL
A10242 CP-724714 <1 mg/mL 94 mg/mL 94 mg/mL
A10362 Erlotinib hydrochloride <1 mg/mL 3 mg/mL <1 mg/mL
A10422 Gefitinib (Iressa) <1 mg/mL 89 mg/mL 4 mg/mL
A10514 Lapatinib Ditosylate <1 mg/mL 185 mg/mL <1 mg/mL
A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
A10706 Pelitinib (EKB-569) <1 mg/mL 13 mg/mL <1 mg/mL
A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
A10991 WZ4002 13 mg/mL <1 mg/mL <1 mg/mL
A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

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