JAK / Stat

Items 1 to 50 of 230 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction
  1. INCB018424 (Ruxolitinib)

    Catalog No. A11041
    Quick View
    JAK1/2 Inhibitor
    INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively; Learn More
  2. PF-03394197 (oclacitinib)

    Catalog No. A13082
    Quick View
    JAK1 inhibitor
    PF-03394197 (oclacitinib) is a potent JAK1 inhibitor Learn More
  3. CP-690550 (Tofacitinib citrate)

    Catalog No. A10241
    Quick View
    JAK3 inhibitor
    CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes. Learn More
  4. GLPG0634

    Catalog No. A13162
    Quick View
    JAK1 inhibitor
    GLPG0634 is an orally-available, selective inhibitor of JAK1 (Janus kinase 1) being developed by Galapagos for the treatment of rheumatoid arthritis and potentially other inflammatory diseases. Learn More
  5. AT9283

    Catalog No. A10095
    Quick View
    Aurora/JAK inhibitor
    AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation. Learn More
  6. AG-490

    Catalog No. A10047
    Quick View
    EGFR inhibitor
    AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src. Learn More
  7. Cyt387 (Momelotinib)

    Catalog No. A10263
    Quick View
    JAK inhibitor
    CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. Learn More
  8. Pacritinib (SB1518)

    Catalog No. A12694
    Quick View
    JAK2/FLT3 inhibitor
    Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis. Learn More
  9. INCB39110 (Itacitinib)

    Catalog No. A14390
    Quick View
    JAK1 Inhibitor
    INCB39110 is a potent JAK1 tyrosine kinase inhibitor, which is currently in Phase II trials for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis. Learn More
  10. Curcumol

    Catalog No. A10247
    Quick View
    JAK2 inhibitor
    Curcumol induces apoptosis via caspases-independent mitochondrial pathway in human lung adenocarcinoma ASTC-a-1 cells. Learn More
  11. PRT 062070 (Cerdulatinib)

    Catalog No. A14147
    Quick View
    Dual Syk and JAK inhibitor
    PRT062070 is a novel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. Learn More
  12. NSC 42834(JAK2 Inhibitor V, Z3)

    Catalog No. A14132
    Quick View
    JAK2 inhibitor
    Z3 is a novel specific inhibitor of Jak2 tyrosine kinase. Learn More
  13. Filgotinib

    Catalog No. A14232
    Quick View
    JAK inhibitor
    Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Learn More
  14. Solcitinib (GSK2586184)

    Catalog No. A14405
    Quick View
    JAK1 inhibitor
    Solcitinib is a Janus kinase 1 (JAK1) inhibitor. Learn More
  15. Decernotinib

    Catalog No. A14012
    Quick View
    JAK3 inhibitor
    Decernotinib is an oral, selective Janus kinase 3 (JAK3) inhibitor being developed by Vertex. Learn More
  16. ZM 39923 HCl

    Catalog No. A13509
    Quick View
    JAK3 inhibitor
    ZM 39923 HCl is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 M, respectively) Learn More
  17. S-Ruxolitinib

    Catalog No. A14955
    Quick View
    JAK inhibitor
    S-Ruxolitinib is the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor. Learn More
  18. CYT387 sulfate salt

    Catalog No. A15056
    Quick View
    JAK inhibitor
    CYT387 sulfate salt is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Learn More
  19. JANEX-1

    Catalog No. A15134
    Quick View
    JAK3 inhibitor
    Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 78 uM); has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. Learn More
  20. 1,2,3,4,5,6-Hexabromocyclohexane

    Catalog No. A15361
    Quick View
    JAK2 inhibitor
    1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation. Learn More
  21. Cercosporamide

    Catalog No. A15362
    Mnk2/JAK3 inhibitor
    Cercosporamide, an usnic amide, was originally identified in Cercosporidium henningsii as a host-selective phytotoxin and broad-spectrum antifungal agent and is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2; IC50 = 11 nM), JAK3 (IC50 = 31), and Mnk1 (IC50 = 116 nM). Learn More
  22. Cucurbitacin I

    Catalog No. A15363
    JAK2/STAT3 inhibitor
    Cucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells. Learn More
  23. SD 1008

    Catalog No. A15364
    Quick View
    JAK2/STAT3 inhibitor
    SD 1008 is reported to be a JAK2/STAT3 signaling pathway inhibitor which additionally inhibits Src. SD 1008 is noted to induce apoptosis in cell lines that express constitutively active tyrosine-phosphorylated STAT3. Learn More
  24. TCS 21311

    Catalog No. A15365
    Quick View
    JAK3 inhibitor
    TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). TCS 21311 is selective for JAK3 over JAK1, JAK2 and Tyk 2 (IC50 values are 1017, 2550 and 8055 nM respectively). Learn More
  25. ZM 449829

    Catalog No. A15366
    Quick View
    JAK/STAT inhibitor
    JAK3 Inhibitor V is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. Learn More
  26. NSC 33994

    Catalog No. A15389
    Quick View
    JAK2 inhibitor
    NSC 33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies. Learn More
  27. Peficitinib (ASP015K, JNJ-54781532)

    Catalog No. A14438
    Quick View
    JAK inhibitor‎
    Peficitinib is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats. Learn More
  28. FLLL32

    Catalog No. A15911
    Quick View
    JAK2 inhibitor
    FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 uM. Learn More
  29. WHI-P97

    Catalog No. A11608
    Quick View
    JAK3 inhibitor
    WHI-P97 is a rationally designed potent inhibitor of JAK-3. Learn More
  30. NS-018

    Catalog No. A16224
    Quick View
    JAK2 inhibitor
    NS-018 is an orally bioavailable, small molecule inhibitor of Janus-associated kinase 2 (JAK2) and Src-family kinases, with potential antineoplastic activity. Learn More
  31. NS-018 hydrochloride

    Catalog No. A16225
    Quick View
    JAK2 inhibitor
    NS-018 hydrochloride is a novel highly selective JAK2 inhibitor. Learn More
  32. NS-018 maleate

    Catalog No. A16226
    Quick View
    JAK2 inhibitor
    NS-018 maleate is an ATP-competitive small-molecule inhibitor of JAK2 with IC50 of 470nM in Ba/F3-JAK2V617F cells . have30-50-fold greater selectivity for JAK2 over other JAK-family kinases, such as JAK1, JAK3 and tyrosine kinase 2. Learn More
  33. ZM39923

    Catalog No. A16227
    Quick View
    JAK1/3 inhibitor
    ZM39923 is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase. Learn More
  34. AZ-3

    Catalog No. A19217
    Quick View
    JAK1 inhibitor
    AZ-3 is a potent and selective JAK1 inhibitor with an IC50 of 34 nM. Learn More
  35. Delgocitinib

    Catalog No. A19234
    Quick View
    JAK inhibitor
    Delgocitinib is a novel and specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. Learn More
  36. JAK1-IN-3

    Catalog No. A19251
    Quick View
    JAK1 inhibitor
    JAK1-IN-3 is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2, and shows little inhibition on JAK3 (IC50, >14.7, >30 μM, respectively). Learn More
  37. JAK-IN-5

    Catalog No. A19792
    Quick View
    JAK inhibitor
    JAK-IN-5 is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283. Learn More
  38. Gusacitinib

    Catalog No. A19883
    Quick View
    SYK/JAK inhibitor
    Gusacitinib (ASN-002) is a potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM. Learn More
  39. JAK-IN-3

    Catalog No. A20220
    Quick View
    JAK inhibitor
    JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively. Learn More
  40. JAK-IN-4

    Catalog No. A20230
    Quick View
    JAK inhibitor
    JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model. Learn More
  41. SAR-20347

    Catalog No. A20380
    Quick View
    TYK2/JAK1/JAK2/JAK3 inhibitor
    SAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41 nM, respectively. Learn More
  42. JAK3-IN-1

    Catalog No. A20734
    Quick View
    JAK3 inhibitor
    JAK3-IN-1 is a potent JAK3 inhibitor with IC50 of 4.8 nM, also inhibits JAK1 (IC50 = 896 nM) and JAK2 (IC50 = 1050 nM). Learn More
  43. AZD1480

    Catalog No. A10110
    Quick View
    JAK Inhibitor
    AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM. Learn More
  44. LY2784544 (Gandotinib)

    Catalog No. A10546
    Quick View
    JAK inhibitor
    LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders. Learn More
  45. TG-101348 (Fedratinib, SAR302503)

    Catalog No. A11082
    Quick View
    JAK2/FLT3 inhibitor
    TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity. Learn More
  46. AZ-960

    Catalog No. A10104
    Quick View
    JAK2inhibitor
    AZ-960 is a potent, selective and ATP competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45 nM in vitro and induces growth arrest and apoptosis in adult T-cell leukemia (ATL) cell. Learn More
  47. TG101209

    Catalog No. A11180
    Quick View
    JAK2 inhibitor

    TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

    Learn More
  48. NVP-BSK805

    Catalog No. A11193
    Quick View
    JAK inhibitor

    NVP-BSK805 is a potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor that potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.

    Learn More
  49. Baricitinib (LY3009104)

    Catalog No. A11329
    Quick View
    JAK Inhibitor
    Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM). Learn More
  50. WP1066

    Catalog No. A11795
    Quick View
    JAK Inhibitor
    WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation. Learn More

Items 1 to 50 of 230 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction
Rewards