Apremilast (CC 10004) ON SALE PDE4 Inhibitor

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Catalog No. A11289

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Apremilast 2mg A11289-2

Regular Price: $100.00

Special Price: $85.00

Apremilast 5mg A11289-5

Regular Price: $180.00

Special Price: $153.00

Apremilast 10mg A11289-10

Regular Price: $320.00

Special Price: $272.00

Apremilast 25mg A11289-25

Regular Price: $600.00

Special Price: $510.00

Apremilast 200mg A11289-200
$2,000.00
Apremilast (CC 10004) 10mM * 1mL in DMSO A11289-10mM-D

Regular Price: $289.00

Special Price: $245.65

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.

Apremilast (CC 10004)

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Chemical Information

Catalog Num A11289
Actions Inhibitor
M. Wt 460.5
Formula C22H24N2O7S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 608141-41-9
Synonyms CC10004, CC-10004
SMILES code CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
Chemical Name N-[2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl] acetamide

Biological Activity

Description
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.

Solubility

Solubility (25°C) * In vitro DMSO 92 mg/mL (199.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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