Cell Metabolism

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  1. Clarithromycin

    Catalog No. A10225
    cytochrome P4503A4 inhibitor
    Clarithromycin is a macrolide antibiotic. It prevents bacteria from growing by interfering with their protein synthesis. Learn More
  2. Talarozole

    Catalog No. A13113
    Cytochrome P450 inhibitor
    Talarozole inhibits the metabolism of retinoic acid by blocking the cytochrome P450 enzyme isoform CYP26, a retinoic acid hydroxylase. Learn More
  3. Efavirenz

    Catalog No. A15826
    cytochrome P450 inhibitor
    Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Learn More
  4. TAK-700 (Orteronel)

    Catalog No. A11044
    CYP17A1 inhibitor
    TAK-700 (Orteronel) is an oral, non-steroidal androgen synthesis inhibitor that selectively inhibits the 17,20 lyase enzyme. Learn More
  5. Voriconazole (Vfend)

    Catalog No. A10978
    CYP17 inhibitor
    Voriconazole (Vfend) is a triazole antifungal agent that is available as a lyophilized powder for solution for intravenous infusion. Learn More
  6. Abiraterone (CB-7598)

    Catalog No. A10020
    CYP17 inhibitor
    Abiraterone (CB-7598) inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1), an enzyme which is expressed in testicular, adrenal, and prostatic tumor tissues. Learn More
  7. CYP17 inhibitor
    Abiraterone acetate (CB7630) is an orally active acetate ester of the steroidal compound Abiraterone with antiandrogen activity. Abiraterone inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1). Learn More
  8. Avasimibe (CI-1011)

    Catalog No. A10102
    CYP17 inhibitor
    Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor. Learn More
  9. TOK-001 (Galeterone)

    Catalog No. A11138
    CYP17 inhibitor
    TOK-001 (Galeterone) is both an androgen receptor antagonist and CYP17A1 inhibitor. Learn More
  10. TH-302 (Evofosfamide)

    Catalog No. A11144
    TH-302 is a selectively targeting hypoxic regions of solid tumors hypoxia-activated prodrug. Learn More
  11. Alizarin

    Catalog No. A10054
    CYP17 inhibitor
    Alizarin is novelly used as a staining agent in biological research because it stains free calcium and certain calcium compounds a red or light purple color. Learn More
  12. Naringenin

    Catalog No. A10625
    Naringenin is a flavanone, a type of flavonoid, that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Learn More
  13. Sodium Danshensu

    Catalog No. A10853
    Sodium danshensu is a sodium salt of danshensu from the widely used Chinese herb Danshen (Salvia miltiorrhiza Bunge). In vitro and in vivo studies revealed that danshensu possessed diverse pharmacological effects, including relaxation of coronary artery, anticoagulation, protection of myocardial ischemia-reperfusion injury, and antiarrhythmia activities Learn More
  14. Cyproterone acetate

    Catalog No. A11409
    Androgen Receptor antagonist
    Cyproterone acetate is a synthetic derivative of 17-hydroxyprogesterone, and acts as an androgen receptor antagonist as well as a weak progesterone receptor agonist with weak progestational and glucocorticoid activity. Learn More
  15. Apigenin

    Catalog No. A10081
    Protein kinase inhibitor

    Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.

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  16. Baicalein

    Catalog No. A10120
    Lipoxygenase Inhibitor

    Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 µM.

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  17. Posaconazole

    Catalog No. A10744
    CYP3A4 inhibitor
    Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours. Learn More
  18. Ketoconazole

    Catalog No. A10498
    P450 inhibitor
    As an antifungal, ketoconazole is structurally similar to imidazole, and interferes with the fungal synthesis of ergosterol, a constituent of fungal cell membranes, as well as certain enzymes. Learn More
  19. Cobicistat (GS-9350)

    Catalog No. A11277
    CYP3A Inhibitor
    Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate. Learn More
  20. Chloramphenicol

    Catalog No. A10200
    Chloramphenicol is a bacteriostatic antimicrobial. Learn More
  21. Clotrimazole

    Catalog No. A10234
    Action of clotrimazole is against the division and growing of fungi.Clotrimazole alters the permeability of the fungal cell wall and inhibits the activity of enzymes within the cell. It specifically inhibits the biosynthesis of ergosterol and other sterols required for cell membrane production. Learn More
  22. Deferasirox

    Catalog No. A10293
    Iron chelator
    Deferasirox is a rationally-designed oral iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Learn More
  23. Itraconazole (Sporanox)

    Catalog No. A10489
    Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Learn More
  24. TMS

    Catalog No. A11977
    TMS is a potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC50= 6 nM). 5N/A- and 520-fold selective over P450 1A1 and 1A2 respectively. Learn More
  25. Methoxsalen (Oxsoralen)

    Catalog No. A10578
    Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). Learn More
  26. Hydroxyflutamide (Hydroxyniphtholide) is a metabolite of flutamide found to inhibit the proliferation of estradiol-induced growth of MCF-7 breast cancer cells. Learn More
  27. PF 4981517

    Catalog No. A12544
    CYP3A4 inhibitor
    PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively). Learn More
  28. Ozagrel(OKY-046)

    Catalog No. A10688
    TXAS inhibitor
    Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM. Learn More
  29. ABT

    Catalog No. A13361
    Cytochrome P450 inhibitor
    ABT (1-Aminobenzotriazole )is a suicide substrate for (CYP)cytochrome P-450 and chloroperoxidase. Learn More
  30. 3-Cyano-7-ethoxycoumarin

    Catalog No. A13365
    Fluorescent P450 substrate
    3-Cyano-7-ethoxycoumarin is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases. It is a fluorescent probe useful in microsomal dealkylase studies. Learn More
  31. Mephenytoin

    Catalog No. A13366
    CYP2C19 and CYP2B6 substrate
    Mephenytoin is a CYP2C19 substrate. Anticonvulsant. Learn More
  32. Methoxyresorufin

    Catalog No. A13367
    cytochrome P450 substrate
    Methoxyresorufin is a fluorometric substrate for cytochrome P450 linked enzymes. Learn More
  33. CYP17A1/androgen synthesis inhibitor
    Orteronel (TAK700) is an androgen synthesis inhibitor. It selectively inhibits the enzyme CYP17A which is expressed in testicular, adrenal, and prostatic tumor tissues. Learn More
  34. Luliconazole

    Catalog No. A11481
    Luliconazole is an azole antifungal indicated for the topical treatment of interdigital tinea pedis. Learn More
  35. Choline Fenofibrate

    Catalog No. A15044
    CYP2C19/CYP2B6 inhibitor
    Choline Fenofibrate (ABT-335) is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia. Learn More
  36. Azathramycin

    Catalog No. A15010
    CYP3A4 Inhibitor
    Azithromycin, derived from erythromycin, is a antibiotic. Azithromycin binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA. Learn More
  37. Benzbromarone

    Catalog No. A16201
    CYP2C9 inhibitor
    Benzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM. Learn More
  38. Chlorzoxazone

    Catalog No. A16449
    Chlorzoxazone is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1. Learn More

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