AZ 3146

Catalog No.: A11170
Mps1 inhibitor

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Grouped product items
Product Name Price Stock Qty
AZ 3146 5mg
$50.00
In stock
AZ 3146 10mg
$80.00
In stock
AZ 3146 50mg
$240.00
In stock
AZ 3146 100mg
$450.00
In stock
AZ 3146 10mM * 1mL in DMSO
$90.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's AZ 3146 has been cited by 5 publications
  • Ryoko Ota, .et al. , Cell Signal, 2023, Sep;109:110764 PMID: 37315749
  • Ryuzaburo Yuki, .et al. , J Cell Mol Med, 2021, Feb;25(3):1677-1687 PMID: 33465289
  • Yamagishi A, .et al. , Int J Mol Sci, 2020, Feb 5;21(3) PMID: 32033461
  • Kakihana A, .et al. , FASEB J, 2018, Nov 29:fj201801369R PMID: 30496702
  • Suzuki M, .et al. , Anticancer Res, 2016, Jun;36(6):2783-92 PMID: 27272789
  • Biological Activity
    Discription

    AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

    Targets
    Target Value
    Product Information
    Catalog Num A11170
    Formula C24H32N6O3
    Molecular Weight 452.55
    CAS Number 1124329-14-1
    SMILES CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
    Synonyms AZ-3146
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 27 mg/mL (59.66 mM)
    Water Insoluble
    Ethanol 87 mg/mL (192.24 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.1 mL 110.49 mL 220.97 mL
    0.5 mM 4.42 mL 22.1 mL 44.19 mL
    1 mM 2.21 mL 11.05 mL 22.1 mL
    5 mM 0.44 mL 2.21 mL 4.42 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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