Cytoskeleton

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    TR-14035

    Catalog No. A17118
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    Integrin Antagonist
    TR-14035 is a dual antagonist of α4β7 and α4β1 integrins. Learn More
  1. Cucurbitacin B

    Catalog No. A14665
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    Microtubule polymerization inhibitor
    Cucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. Also it is an potent Microtubule polymerization inhibitor Learn More
  2. Sagopilone

    Catalog No. A14328
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    microtubule stabilizer
    Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Learn More
  3. VcMMAE

    Catalog No. A14362
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    VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Learn More
  4. Vinorelbine Tartrate

    Catalog No. A14295
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    Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Learn More
  5. INH6

    Catalog No. A14200
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    Hec1 Inhibitor
    INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. Learn More
  6. INH1

    Catalog No. A13872
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    Hec1 imhibitor
    INH1 is a Hec1 inhibitor. It binds Hec1, inhibiting its association with Nek2 and kinetochores. Learn More
  7. CW069

    Catalog No. A13735
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    Microtubule Associated inhibitor
    CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 uM, significant selectivity over KSP. Learn More
  8. Cabazitaxel

    Catalog No. A11831
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    Microtubule Associated inhibitor
    Cabazitaxel is a semi-synthetic derivative of a natural taxoid. Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment Learn More
  9. CK-636

    Catalog No. A13827
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    Arp2/3 inhibitor
    CK-636 is a Arp2/3 complex inhibitor. CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. Learn More
  10. 7-Epi 10-Desacetyl Paclitaxel

    Catalog No. A14980
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    7-Epi 10-Desacetyl Paclitaxel is a derivative of Paclitaxel, which is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. Learn More
  11. 7-xylosyltaxol

    Catalog No. A14981
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    7-xylosyltaxol is a taxol derivative, Paclitaxel binds to tubulin and inhibits the disassembly of microtubules. Learn More
  12. TRx0237 (LMTX) mesylate

    Catalog No. A16124
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    tau protein aggregation inhibitor
    TRx 0237 (LMT) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Learn More
  13. DM1-Sme

    Catalog No. A15960
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    maytansinoid microtubular inhibitor
    DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. Learn More
  14. Vinblastine sulfate

    Catalog No. A13661
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    microtubule dynamics inhibitor
    Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Learn More
  15. ELR510444

    Catalog No. A15455
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    Microtubule Disruptor
    ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in ??III-tubulin-overexpressing cell lines. Learn More
  16. D-64131

    Catalog No. A14442
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    Tubulin inhibitor
    D-64131 is a novel inhibitor of tubulin polymerization that inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Learn More
  17. Vc-MMAD

    Catalog No. A15273
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    Tubulin inhibitor
    Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate. Learn More
  18. MMAD

    Catalog No. A15172
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    Tubulin inhibitor
    MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. Learn More
  19. Mc-MMAD

    Catalog No. A15156
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    Tubulin inhibitor
    Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate; Mc-MMAD is a protective group (maleimidocaproyl) -conjugated MMAD. Learn More
  20. Docetaxel Trihydrate

    Catalog No. A15070
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    Docetaxel trihydrate, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. Learn More
  21. Monomethyl auristatin E

    Catalog No. A12954
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    Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity. Learn More
  22. Colchicine

    Catalog No. A10238
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    Colchicine is an inhibitor of microtubules by specific binding to tubulin. Learn More
  23. 4-Demethylepipodophyllotoxin

    Catalog No. A10014
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    microtubule assembly inhibitor
    4-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly. Learn More
  24. Vinorelbine (Navelbine)

    Catalog No. A10976
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    Vinorelbine is the first 5´NOR semi-synthetic vinca alkaloid. It is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus. Learn More
  25. ABT-751 (E-7010)

    Catalog No. A10024
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    Microtubule Associated inhibitor
    ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. Learn More
  26. CYT997 (Lexibulin)

    Catalog No. A10264
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    Microtubule Inhibitor
    CYT997 is a novel anti-cancer vascular disrupting agent (VDA). In vitro, CYT997 is shown to potently inhibit the proliferation of vascular endothelial growth factor-stimulated human umbilical vein endothelial cells (IC(50) 3.7 ± 1.8 nM) and cause significant morphological changes at 100 nM, including membrane blebbing. Learn More
  27. Vinflunine Tartrate

    Catalog No. A10975
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    Microtubule Associated inhibitor
    Vinflunine Tartrate is a tartrate salt of vinflunine that destabilizes microtubules with an IC50 of 18.8 nM and interferes with the dynamics of microtubules during cell division. Learn More
  28. Epothilone B (EPO906)

    Catalog No. A10360
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    Microtubule Associated inhibitor
    Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. Learn More
  29. Epothilone A

    Catalog No. A10359
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    Microtubule Associated inhibitor
    Epothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Learn More
  30. Vincristine sulfate

    Catalog No. A10973
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    Tubulin inhibitor
    Vincristine is a mitotic inhibitor, and is used in cancer chemotherapy. Learn More
  31. Paclitaxel (Taxol)

    Catalog No. A10689
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    Microtubule Associated inhibitor
    Paclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Learn More
  32. Docetaxel (Taxotere)

    Catalog No. A10326
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    Microtubule Associated inhibitor
    Docetaxel (Taxotere) is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions. Learn More
  33. Chloroxine

    Catalog No. A10204
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    Chloroxine is an antibacterial drug useful for dandruff and seborrheic dermatitis. Learn More
  34. Albendazole

    Catalog No. A10049
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    Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. Learn More
  35. Epothilone D

    Catalog No. A11412
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    Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. Learn More
  36. Ansamitocin P-3

    Catalog No. A13268
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    microtubule depolymerizing agent
    Ansamitocin P-3 is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. Learn More
  37. Nocodazole

    Catalog No. A13219
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    microtubule inhibitor
    Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion. Learn More
  38. Fosbretabulin disodium (CA4P)

    Catalog No. A13081
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    microtubule-targeting agent
    Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Learn More
  39. Eribulin Mesylate

    Catalog No. A12804
    Eribulin mesylate is the mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Learn More
  40. Vincristine

    Catalog No. A11617
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    Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM. Learn More
  41. Combretastatin A4

    Catalog No. A12601
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    Combretastatin A4 is an antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. Learn More
  42. Cevipabulin (TTI-237)

    Catalog No. A12591
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    Cevipabulin (TTI-237), an antimicrotubule agent, is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. Learn More
  43. Ixabepilone

    Catalog No. A11449
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    microtubule inhibitor
    Ixabepilone is an epothilone B analog Learn More
  44. Podophyllotoxin

    Catalog No. A10740
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    Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin. Learn More
  45. FRAX597

    Catalog No. A12553
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    PAK inhibitor
    FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM). Learn More
  46. KPT-9274

    Catalog No. A15506
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    PAK4 Inhibitor
  47. FRAX486

    Catalog No. A13691
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    PAK inhibitor
    FRAX486 is a small-molecule PAK inhibitor. Learn More
  48. LOR-253

    Catalog No. A13838
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    MTF-1 inhibitor
    LOR-253 is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1). Learn More
  49. PF-3758309

    Catalog No. A11930
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    PAK4 inhibitor
    PF-3758309 is a small-molecule p21-activated kinase inhibitor inhibiting oncogenic signaling and tumor growth. Learn More

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