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Cytoskeleton

Items 1-50 of 745

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  1. A11435
    GSK-923295

    CENP-E inhibitor

    GSK-923295, is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E, (CENP-E).
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  2. A13647
    (-)-Blebbistcitin

    myosin II inhibitor

    Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light.
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  3. A10495
    Kaempferol

    ERRα and ERRγ inverse agonist

    Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway.
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  4. A11412
    Epothilone D
    Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
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  5. A13838
    LOR-253

    MTF-1 inhibitor

    LOR-253 is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1).
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  6. A10976
    Vinorelbine (Navelbine)
    Vinorelbine is the first 5??NOR semi-synthetic vinca alkaloid. It is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus.
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  7. A13219
    Nocodazole

    microtubule inhibitor

    Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.
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  8. A11449
    Ixabepilone

    microtubule inhibitor

    Ixabepilone is an epothilone B analog
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  9. A12553
    FRAX597

    PAK inhibitor

    FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).
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  10. A12787
    Firategrast (SB 683699)

    α4β1/α4β7 integrin antagonist

    Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS).
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  11. A11206
    CK-1827452 (Omecamtiv mecarbil)

    Myosin activator

    CK-1827452 is a selective cardiac specific myosin activator.
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  12. A12037
    Luvixasertib (CFI-402257)

    TTK inhibitor

    CFI-402257, a pyrazolopyridin derivative, has been found to be a TTK inhibitor that could influence chromosome segregation and induce cell death so that is significant in anticancer studies.
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  13. A20973
    CK-666

    Arp2/3 complex inhibitor

    CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation.
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  14. A14923
    Cyclo (-RGDfK)

    αvβ3 integrin inhibitor

    Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin.
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  15. A11170
    AZ 3146

    Mps1 inhibitor

    AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

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  16. A15538
    RGD (Arg-Gly-Asp) Peptides

    Inhibits integrin binding to RGD motifs

    RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
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  17. A14288
    (E)-KN-93 phosphate

    CaMKII inhibitor

    KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.
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  18. A15915
    Dyngo-4a

    Dynamin inhibitor

    Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 uM, 1.1uM, and 2.3 uM for DynI (brain), DynI (rec), and DynII (rec), respectively.
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  19. A11617
    Vincristine
    Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM.
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  20. A14865
    Gap 26

    Gap junction blocker

    Gap 26 is a connexin mimetic peptide, corresponding to residues 63-75 of connexin 43, which is a gap junction blocker.
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  21. A12372
    Cilengitide

    Integrin inhibitor

    Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
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  22. A11614
    Zaurategrast (CDP323)

    VCAM-1 antagonist

    CDP323 is a small-molecule prodrug antagonist of the vascular cell adhesion molecule 1 binding to ??4-integrins
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  23. A13691
    FRAX486

    PAK inhibitor

    FRAX486 is a small-molecule PAK inhibitor.
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  24. A15070
    Docetaxel Trihydrate
    Docetaxel trihydrate, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
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  25. A10689
    Paclitaxel (Taxol)

    Microtubule Associated inhibitor

    Paclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division.
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  26. A14328
    Sagopilone

    microtubule stabilizer

    Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity.
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  27. A11936
    ML 7 hydrochloride

    MLCK inhibitor

    ML 7 hydrochloride is a selective inhibitor of myosin light chain kinase (MLCK).
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  28. A14866
    Gap 27

    Gap junction blocker

    Gap 27 is a peptide derived from connexin 43 that is a selective gap junction blocker.
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  29. A11831
    Cabazitaxel

    Microtubule Associated inhibitor

    Cabazitaxel is a semi-synthetic derivative of a natural taxoid. Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment
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  30. A10326
    Docetaxel (Taxotere)

    Microtubule Associated inhibitor

    Docetaxel (Taxotere) is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions.
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  31. A12804
    Eribulin Mesylate
    Eribulin mesylate is the mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity.
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  32. A12954
    Monomethyl auristatin E
    Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
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  33. A17185
    Obtustatin

    α1β1 inhibitor

    Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.
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  34. A14316
    Mdivi-1

    DRP1 inhibitor

    Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 uM.
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  35. A12726
    Dynasore

    Dynamin inhibitor

    Dynasore is a non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity
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  36. A13081
    Fosbretabulin disodium (CA4P)

    microtubule-targeting agent

    Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities.
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  37. A12591
    Cevipabulin (TTI-237)
    Cevipabulin (TTI-237), an antimicrotubule agent, is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules.
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  38. A10238
    Colchicine
    Colchicine is an inhibitor of microtubules by specific binding to tubulin.
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  39. A12371
    Cilengitide trifluoroacetate

    Integrin inhibitor

    Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
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  40. A15091
    GAP-134 (Danegaptide)

    Gap Junction Modifier

    GAP-134 , a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.
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  41. A10360
    Epothilone B (EPO906)

    Microtubule Associated inhibitor

    Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.
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  42. A12876
    Pyrintegrin
    Pyrintegrin is a cell-permeable small molecule that promotes human embryonic stem cell (hESC) survival by > 30-fold.
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  43. A11218
    Mps1-IN-1

    Mps1 inhibitor

    Mps1-IN-1 is a highly potent and selectibe Mpsl inhibitor with IC50 of 367 nM; >1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk.
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  44. A11593
    Tonabersat (SB-220453)

    gap-junction modulator

    Tonabersat is a novel benzopyran derivative that blocks the cortical spreading depression proposed to be associated with migraine attacks.
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  45. A11930
    PF-3758309

    PAK4 inhibitor

    PF-3758309 is a small-molecule p21-activated kinase inhibitor inhibiting oncogenic signaling and tumor growth.
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  46. A11976
    Monastrol

    Kinesin-5(KIF11) inhibitor

    Monastrol is a potent, cell permeable non-tubulin-interacting mitosis inhibitor. Monastrol blocks mitosis (IC5N/A = 14 μM) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity.
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  47. A12170
    SS28
    SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin.
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  48. A13423
    GLPG0187

    Integrin receptor antagonist

    GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM.
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  49. A13584
    A-3 Hydrochloride

    PKA, PKG, Casein Kinase I and II inhibitor

    A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).
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  50. A13661
    Vinblastine sulfate

    microtubule dynamics inhibitor

    Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
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