AZ191

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Catalog No. A14314

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AZ191 10mg A14314-10

Regular Price: $90.00

Special Price: $76.50

AZ191 25mg A14314-25

Regular Price: $180.00

Special Price: $153.00

AZ191 50mg A14314-50

Regular Price: $250.00

Special Price: $212.50

AZ191 10mM * 1mL in DMSO A14314-10mM-D

Regular Price: $66.00

Special Price: $56.10

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM, about 5- and 110-fold selectivity over DYRK1A and DYRK2.

AZ191

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Chemical Information

Catalog Num A14314
Actions N/A
M. Wt 429.52
Formula C24H27N7O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1594092-37-1
Synonyms AZ 191, AZ-191
SMILES code CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=CC(=N3)C4=CN(C5=C4C=CN=C5)C)OC
Chemical Name N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine

Biological Activity

Description
AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM, about 5- and 110-fold selectivity over DYRK1A and DYRK2.
Targets
Dyrk1B (Cell-free assay) DYRK1A (Cell-free assay) DYRK2 (Cell-free assay)
17 nM88 nM1890 nM

Solubility

Solubility (25°C)* In vitro DMSO 86 mg/mL (200.22 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL (2.32 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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