Cell Cycle

Items 1 to 50 of 181 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4

Set Descending Direction
  1. CCT241533 hydrochloride

    Catalog No. A15038
    Quick View
    Chk2 inhibitor
    CCT241533 Hcl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM; shows minimal cross-reactivity against a panel of kinases at 1 uM. Learn More
  2. CCT244747

    Catalog No. A15550
    Quick View
    CHK1 inhibitor
    CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity, Learn More
  3. SB 218078

    Catalog No. A15480
    Quick View
    Chk1 Inhibitor
    SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively) Learn More
  4. AZD7762

    Catalog No. A10113
    Quick View
    Chk1 & Chk2 inhibitor
    AZD7762 is a potent ATP-competitive checkpoint kinase inhibitor that drives checkpoint abrogation and potentiates DNA-targeted therapies. Learn More
  5. LY2603618 (IC-83)

    Catalog No. A11036
    Quick View
    Chk inhibitor
    LY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents. Learn More
  6. CHIR-124

    Catalog No. A11046
    Quick View
    CHK Inhibitor
    CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively). Learn More
  7. CCT241533

    Catalog No. A11108
    Quick View
    Chk2 inhibitor
    CCT241533 is a potent and selective Inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Learn More
  8. SCH 900776 (MK-8776)

    Catalog No. A11167
    Quick View
    Chk1 inhibitor

    SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

    Learn More
  9. PF 477736

    Catalog No. A11520
    Quick View
    Chk Inhibitor
    PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Learn More
  10. SCH900776 (S-isomer)

    Catalog No. A12703
    Quick View
    CHK1 Inhibitor
    SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Learn More
  11. BML-277

    Catalog No. A13575
    Quick View
    Chk2 Inhibitor
    BML-277 (Chk2 Inhibitor II) is a Chk2 (checkpoint kinase 2) inhibitor. Learn More
  12. GNE-900

    Catalog No. A14178
    Chk1 inhibitor
    GNE-900 is an ATP-competitive, selective, and orally bioavailable ChK1 inhibitor. Learn More
  13. LY2606368

    Catalog No. A13684
    Quick View
    Chk1 inhibitor
    LY2606368 is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. Learn More
  14. PD0166285

    Catalog No. A15863
    Quick View
    Wee1 inhibitor
    PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator. Learn More
  15. GDC-0575 (ARRY-575, RG7741)

    Catalog No. A16811
    Quick View
    Chk1 inhibitor
    GDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2?nM. Learn More
  16. LY2835219 (abemaciclib)

    Catalog No. A12989
    Quick View
    CDK4/6 inhibitor
    LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Learn More
  17. BMS-863233 (XL-413)

    Catalog No. A13677
    Quick View
    CDK inhibitor
    BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. Learn More
  18. P276-00

    Catalog No. A13547
    Quick View
    CDK Inhibitor
    P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3 Learn More
  19. LEE011 (Ribociclib)

    Catalog No. A13549
    Quick View
    CDK4/6 inhibitor
    LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Learn More
  20. LDC000067

    Catalog No. A14273
    Quick View
    CDK inhibitor
    LDC000067 is a highly selective CDK9 inhibitor . Learn More
  21. AMG-925

    Catalog No. A14025
    Quick View
    Dual FLT3/CDK4 inhibitor
    AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. Learn More
  22. CVT-313

    Catalog No. A15054
    Quick View
    CDK2 Inhibitor
    CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 215 uM for Cdk4/D1). Learn More
  23. Purvalanol A

    Catalog No. A15517
    Quick View
    CDK inhibitor
    Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Learn More
  24. NVP-LCQ195

    Catalog No. A15196
    Quick View
    CDK inhibitor
    NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. Learn More
  25. AG-024322

    Catalog No. A15485
    Quick View
    CDK inhibitor
    AG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models. Learn More
  26. NU2058

    Catalog No. A15767
    Quick View
    CDK inhibitor
    NU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1. Learn More
  27. PD 0332991 HCl (Palbociclib)

    Catalog No. A10701
    Quick View
    CDK 4/6 inhibitor
    PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More
  28. Flavopiridol (Alvocidib)

    Catalog No. A10390
    Quick View
    CDK inhibitor
    Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. Learn More
  29. Indirubin

    Catalog No. A10471
    Quick View
    CDK & GSK-3β inhibitor
    Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM. Learn More
  30. A-674563

    Catalog No. A11034
    Quick View
    Akt inhibitor
    A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More
  31. Roscovitine (Seliciclib)

    Catalog No. A10806
    Quick View
    CDK Inhibitor
    Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9. Learn More
  32. SNS-032 (BMS-387032)

    Catalog No. A10850
    Quick View
    CDK inhibitor
    SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells. Learn More
  33. PHA-793887

    Catalog No. A10716
    Quick View
    CDK Inhibitor
    PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines. Learn More
  34. AT7519

    Catalog No. A10093
    Quick View
    CDK Inhibitor
    AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Learn More
  35. BS-181 HCl

    Catalog No. A10163
    Quick View
    CDK inhibitor
    BS-181 HCl is a potential anti-tumor agent as CDK7 inhibitor. Learn More
  36. Flavopiridol HCl

    Catalog No. A11045
    Quick View
    CDK inhibitor
    Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells. Learn More
  37. JNJ-7706621

    Catalog No. A10494
    Quick View
    CDK/Aurora A/B Inhibitor
    JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1. Learn More
  38. PHA-848125 (Milciclib)

    Catalog No. A11047
    CDK Inhibitor
    PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity. Learn More
  39. AZD5438

    Catalog No. A11105
    Quick View
    CDK inhibitor
    AZD5438 is a potent inhibitor of cyclin-dependent kinase (CDK) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). Learn More
  40. BMS-265246

    Catalog No. A11154
    Quick View
    CDK inhibitor
    BMS-265246 is a potent new pyra- zolopyridine inhibitor of cdk2/cyclin E and cdk1/cyclin B, as well as cdk4/cyclin D. Learn More
  41. PHA-767491

    Catalog No. A11164
    Quick View
    Cdc7/cdk9 inhibitor

    PHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication.

    Learn More
  42. R547

    Catalog No. A11190
    Quick View
    CDK inhibitor

    R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.

    Learn More
  43. Dinaciclib (SCH 727965)

    Catalog No. A11129
    Quick View
    CDK Inhibitor
    Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively. Learn More
  44. Kenpaullone

    Catalog No. A11220
    Quick View
    CDK inhibitor
    Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases. Learn More
  45. AT7519 HCl

    Catalog No. A11313
    Quick View
    CDK inhibitor
    AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Learn More
  46. CGP60474

    Catalog No. A11347
    Quick View
    CDK Inhibitor
    CGP60474 is a potent inhibitor of cyclin-dependent kinase (CDK). Learn More
  47. Purvalanol B

    Catalog No. A12352
    Quick View
    CDK inhibitor
    Purvalanol B is a cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC50 > 10,000 nM). Learn More
  48. NU 6102

    Catalog No. A12438
    Quick View
    CDK inhibitor
    NU6102 is selective for CDK1 and CDK2 compared to CDK4/D1 (IC50=1.6 μM), DYRK1A (IC50=0.9 μM), PDK1 (IC50=0.8 μM) and ROCKII (IC50=0.6 μM). Learn More
  49. BAY 1000394 (Roniciclib)

    Catalog No. A12742
    CDK inhibitor
    BAY 1000394 is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More
  50. Wogonin

    Catalog No. A12216
    Quick View
    CDK9 inhibitor
    Wogonin is an anti-inflammatory agent and an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase Learn More

Items 1 to 50 of 181 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4

Set Descending Direction
Rewards