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Cell Cycle
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A15038 |
CCT241533 hydrochloride |
Chk2 inhibitor |
CCT241533 Hcl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM; shows minimal cross-reactivity against a panel of kinases at 1 uM.
|
A15550 |
CCT244747 |
CHK1 inhibitor |
CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity,
|
A15480 SALE |
SB 218078 |
Chk1 Inhibitor |
SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively)
|
A10113 SALE |
AZD7762 |
Chk1 & Chk2 inhibitor |
AZD7762 is a potent ATP-competitive checkpoint kinase inhibitor that drives checkpoint abrogation and potentiates DNA-targeted therapies.
|
A11036 SALE |
LY2603618 (IC-83) |
Chk inhibitor |
LY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents.
|
A11046 SALE |
CHIR-124 |
CHK Inhibitor |
CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).
|
A11108 |
CCT241533 |
Chk2 inhibitor |
CCT241533 is a potent and selective Inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.
|
A11167 SALE |
SCH 900776 (MK-8776) |
Chk1 inhibitor |
SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents. |
A11520 SALE |
PF 477736 |
Chk Inhibitor |
PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).
|
A12703 SALE |
SCH900776 (S-isomer) |
CHK1 Inhibitor |
SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.
|
A13575 SALE |
BML-277 |
Chk2 Inhibitor |
BML-277 (Chk2 Inhibitor II) is a Chk2 (checkpoint kinase 2) inhibitor.
|
A14178 |
GNE-900 |
Chk1 inhibitor |
GNE-900 is an ATP-competitive, selective, and orally bioavailable ChK1 inhibitor.
|
A13684 SALE |
LY2606368 |
Chk1 inhibitor |
LY2606368 is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
|
A15863 |
PD0166285 |
Wee1 inhibitor |
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.
|
A12989 SALE |
LY2835219 (abemaciclib) |
CDK4/6 inhibitor |
LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.
|
A13677 SALE |
BMS-863233 (XL-413) |
CDK inhibitor |
BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity.
|
A13547 SALE |
P276-00 |
CDK Inhibitor |
P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3
|
A13549 SALE |
LEE011 (Ribociclib) |
CDK4/6 inhibitor |
LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
|
A14273 |
LDC000067 |
CDK inhibitor |
LDC000067 is a highly selective CDK9 inhibitor .
|
A14025 |
AMG-925 |
Dual FLT3/CDK4 inhibitor |
AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor.
|
A15054 |
CVT-313 |
CDK2 Inhibitor |
CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 215 uM for Cdk4/D1).
|
A15517 SALE |
Purvalanol A |
CDK inhibitor |
Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.
|
A15196 |
NVP-LCQ195 |
CDK inhibitor |
NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.
|
A15485 |
AG-024322 |
CDK inhibitor |
AG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models.
|
A15767 |
NU2058
|
CDK inhibitor |
NU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1.
|
A10701 SALE |
PD 0332991 HCl (Palbociclib) |
CDK 4/6 inhibitor |
PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
|
A10390 SALE |
Flavopiridol (Alvocidib) |
CDK inhibitor |
Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.
|
A10471 SALE |
Indirubin |
CDK & GSK-3β inhibitor |
Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.
|
A11034 SALE |
A-674563 |
Akt inhibitor |
A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
|
A10806 SALE |
Roscovitine (Seliciclib) |
CDK Inhibitor |
Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.
|
A10850 SALE |
SNS-032 (BMS-387032) |
CDK inhibitor |
SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.
|
A10716 SALE |
PHA-793887 |
CDK Inhibitor |
PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines.
|
A10093 SALE |
AT7519 |
CDK Inhibitor |
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.
|
A10163 SALE |
BS-181 HCl |
CDK inhibitor |
BS-181 HCl is a potential anti-tumor agent as CDK7 inhibitor.
|
A11045 SALE |
Flavopiridol HCl |
CDK inhibitor |
Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells.
|
A10494 |
JNJ-7706621 |
CDK/Aurora A/B Inhibitor |
JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.
|
A11047 |
PHA-848125 (Milciclib) |
CDK Inhibitor |
PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity.
|
A11105 |
AZD5438 |
CDK inhibitor |
AZD5438 is a potent inhibitor of cyclin-dependent kinase (CDK) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively).
|
A11154 |
BMS-265246 |
CDK inhibitor |
BMS-265246 is a potent new pyra- zolopyridine inhibitor of cdk2/cyclin E and cdk1/cyclin B, as well as cdk4/cyclin D.
|
A11164 SALE |
PHA-767491 |
Cdc7/cdk9 inhibitor |
PHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. |
A11190 SALE |
R547 |
CDK inhibitor |
R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines. |
A11129 SALE |
Dinaciclib (SCH 727965) |
CDK Inhibitor |
Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.
|
A11220 SALE |
Kenpaullone |
CDK inhibitor |
Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases.
|
A11313 SALE |
AT7519 HCl |
CDK inhibitor |
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.
|
A11347 |
CGP60474 |
CDK Inhibitor |
CGP60474 is a potent inhibitor of cyclin-dependent kinase (CDK).
|
A12352 SALE |
Purvalanol B |
CDK inhibitor |
Purvalanol B is a cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC50 > 10,000 nM).
|
A12438 |
NU 6102 |
CDK inhibitor |
NU6102 is selective for CDK1 and CDK2 compared to CDK4/D1 (IC50=1.6 μM), DYRK1A (IC50=0.9 μM), PDK1 (IC50=0.8 μM) and ROCKII (IC50=0.6 μM).
|
A12742 |
BAY 1000394 (Roniciclib)
|
CDK inhibitor |
BAY 1000394 is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity.
|
A12216 |
Wogonin |
CDK9 inhibitor |
Wogonin is an anti-inflammatory agent and an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase
|
A13721 SALE |
TG003 |
Clk inhibitor |
TG003 is a potent, specific, reversible, and ATP competitive inhibitor of Cdc2 like kinase(Clk).-
|
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