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CCT241533 hydrochloride
Catalog No. A15038 Chk2 inhibitorCCT241533 Hcl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM; shows minimal cross-reactivity against a panel of kinases at 1 uM. Learn More -
CCT244747
Catalog No. A15550 CHK1 inhibitorCCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity, Learn More -
SB 218078
Catalog No. A15480 Chk1 InhibitorSB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively) Learn More -
AZD7762
Catalog No. A10113 Chk1 & Chk2 inhibitorAZD7762 is a potent ATP-competitive checkpoint kinase inhibitor that drives checkpoint abrogation and potentiates DNA-targeted therapies. Learn More -
LY2603618 (IC-83)
Catalog No. A11036 Chk inhibitorLY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents. Learn More -
CHIR-124
Catalog No. A11046 CHK InhibitorCHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively). Learn More -
CCT241533
Catalog No. A11108 Chk2 inhibitorCCT241533 is a potent and selective Inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Learn More -
SCH 900776 (MK-8776)
Catalog No. A11167 Chk1 inhibitorSCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.
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PF 477736
Catalog No. A11520 Chk InhibitorPF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Learn More -
SCH900776 (S-isomer)
Catalog No. A12703 CHK1 InhibitorSCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Learn More -
BML-277
Catalog No. A13575 Chk2 InhibitorBML-277 (Chk2 Inhibitor II) is a Chk2 (checkpoint kinase 2) inhibitor. Learn More -
GNE-900
Catalog No. A14178 Chk1 inhibitorGNE-900 is an ATP-competitive, selective, and orally bioavailable ChK1 inhibitor. Learn More -
LY2606368
Catalog No. A13684 Chk1 inhibitorLY2606368 is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. Learn More -
PD0166285
Catalog No. A15863 Wee1/Chk inhibitorPD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator. Learn More -
GDC-0575 (ARRY-575, RG7741)
Catalog No. A16811 Chk1 inhibitorGDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2?nM. Learn More -
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CCT245737
Catalog No. A17239 CHK1 inhibitorCCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%. Learn More -
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CHK1-IN-3
Catalog No. A18443 CHK1 inhibitorCHK1-IN-3 is a Checkpoint Kinase 1 (CHK1) inhibitor with an IC50 of 0.4 nM. Learn More -
LY2835219 (abemaciclib)
Catalog No. A12989 CDK4/6 inhibitorLY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Learn More -
BMS-863233 (XL-413)
Catalog No. A13677 CDK inhibitorBMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. Learn More -
P276-00
Catalog No. A13547 CDK InhibitorP276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3 Learn More -
LEE011 (Ribociclib)
Catalog No. A13549 CDK4/6 inhibitorLEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Learn More -
LDC000067
Catalog No. A14273 -
AMG-925
Catalog No. A14025 Dual FLT3/CDK4 inhibitorAMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. Learn More -
CVT-313
Catalog No. A15054 CDK2 InhibitorCVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 215 uM for Cdk4/D1). Learn More -
Purvalanol A
Catalog No. A15517 CDK inhibitorPurvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Learn More -
NVP-LCQ195
Catalog No. A15196 CDK inhibitorNVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. Learn More -
AG-024322
Catalog No. A15485 CDK inhibitorAG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models. Learn More -
NU2058
Catalog No. A15767 CDK inhibitorNU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1. Learn More -
PD 0332991 HCl (Palbociclib)
Catalog No. A10701 CDK 4/6 inhibitorPD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More -
Flavopiridol (Alvocidib)
Catalog No. A10390 CDK inhibitorFlavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. Learn More -
Indirubin
Catalog No. A10471 CDK & GSK-3β inhibitorIndirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM. Learn More -
A-674563
Catalog No. A11034 Akt inhibitorA-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More -
Roscovitine (Seliciclib)
Catalog No. A10806 CDK InhibitorRoscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9. Learn More -
SNS-032 (BMS-387032)
Catalog No. A10850 CDK inhibitorSNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells. Learn More -
PHA-793887
Catalog No. A10716 CDK InhibitorPHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines. Learn More -
AT7519
Catalog No. A10093 CDK InhibitorAT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Learn More -
BS-181 HCl
Catalog No. A10163 CDK inhibitorBS-181 HCl is a potential anti-tumor agent as CDK7 inhibitor. Learn More -
Flavopiridol HCl
Catalog No. A11045 CDK inhibitorFlavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells. Learn More -
JNJ-7706621
Catalog No. A10494 CDK/Aurora A/B InhibitorJNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1. Learn More -
PHA-848125 (Milciclib)
Catalog No. A11047 CDK InhibitorPHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity. Learn More -
AZD5438
Catalog No. A11105 CDK inhibitorAZD5438 is a potent inhibitor of cyclin-dependent kinase (CDK) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). Learn More -
BMS-265246
Catalog No. A11154 CDK inhibitorBMS-265246 is a potent new pyra- zolopyridine inhibitor of cdk2/cyclin E and cdk1/cyclin B, as well as cdk4/cyclin D. Learn More -
PHA-767491
Catalog No. A11164 Cdc7/cdk9 inhibitorPHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication.
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R547
Catalog No. A11190 CDK inhibitorR547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.
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Dinaciclib (SCH 727965)
Catalog No. A11129 CDK InhibitorDinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively. Learn More -
Kenpaullone
Catalog No. A11220 CDK inhibitorKenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases. Learn More -
AT7519 HCl
Catalog No. A11313 CDK inhibitorAT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Learn More -
CGP60474
Catalog No. A11347 CDK InhibitorCGP60474 is a potent inhibitor of cyclin-dependent kinase (CDK). Learn More -
Purvalanol B
Catalog No. A12352 CDK inhibitorPurvalanol B is a cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC50 > 10,000 nM). Learn More -
NU 6102
Catalog No. A12438 CDK inhibitorNU6102 is selective for CDK1 and CDK2 compared to CDK4/D1 (IC50=1.6 μM), DYRK1A (IC50=0.9 μM), PDK1 (IC50=0.8 μM) and ROCKII (IC50=0.6 μM). Learn More
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