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AZD-9291 (Osimertinib)

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EGFR inhibitor

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Catalog No. A13681

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AZD-9291 5mg A13681-5

Regular Price: $50.00

Special Price: $40.00

AZD-9291 10mg A13681-10

Regular Price: $70.00

Special Price: $56.00

AZD-9291 25mg A13681-25

Regular Price: $100.00

Special Price: $80.00

AZD-9291 50mg A13681-50

Regular Price: $120.00

Special Price: $96.00

AZD-9291 10mM * 1mL in DMSO A13681-10mM-D

Regular Price: $55.00

Special Price: $44.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.

AZD-9291 (Osimertinib)

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Chemical Information

Catalog Num A13681
Actions Inhibitor
M. Wt 499.61
Formula C28H33N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1421373-65-0
Synonyms AZD 9291, AZD9291
SMILES code CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
Chemical Name N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

Biological Activity

Description
AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.
Targets
L858R/T790M EGFR (LoVo cells) Exon 19 deletion EGFR (LoVo cells) WT EGFR (LoVo cells)
11.44 nM12.92 nM493.8 nM

Solubility

Solubility (25°C)* In vitro DMSO 99 mg/mL heating (198.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol 43 mg/mL heating (86.06 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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