AZD2014

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mTORC1/2 inhibitor

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Catalog No. A11303

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AZD2014 5mg A11303-5
$70.00
AZD2014 10mg A11303-10
$120.00
AZD2014 25mg A11303-25
$250.00
AZD2014 50mg A11303-50
$450.00
AZD2014 10mM * 1mL in DMSO A11303-10mM-D
$70.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor.

AZD2014

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Chemical Information

Catalog Num A11303
Actions Inhibitor
M. Wt 462.5
Formula C25H30N6O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1009298-59-2
Synonyms AZD-2014
SMILES code C[[email protected]]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOC[C@@H]5C
Chemical Name 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

Biological Activity

Description
AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor.
Targets
mTOR (Cell-free assay) P-Akt (S473) (Cell-free assay) pS6 (S235/236) (Cell-free assay)
2.8 nM80 nM200 nM

Solubility

Solubility (25°C) * In vitro DMSO 38 mg/mL (82.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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