PI3K / Akt / mTOR

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  1. GDC-0068 (Ipatasertib, RG-7440)

    Catalog No. A11246
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    Akt Inhibitor
    GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays Learn More
  2. TIC10 isomer

    Catalog No. A12720
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    AKT inhibitor‎
    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Learn More
  3. 10-DEBC HCl

    Catalog No. A13590
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    AKT/PKB inhibitor‎
    10-DEBC HCl is a selective inhibitor of Akt/PKB. It inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Learn More
  4. SR-13668

    Catalog No. A13554
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    AKT inhibitor‎
    SR-13668 is an Akt inhibitor, is also an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities. Learn More
  5. Afuresertib HCl

    Catalog No. A13030
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    AKT inhibitor‎
    Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Learn More
  6. SC79

    Catalog No. A15541
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    Akt phosphorylation activator
    SC79 is an AKT activator. SC79 binds to the plecktrin homology (PH) domain of Akt that mimics the binding of PtdIns(3,4,5)P3 to induce a conformational change in Akt that enhances phosphorylation and activation. Learn More
  7. GSK2141795 (Uprosertib, GSK795)

    Catalog No. A15809
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    Akt inhibitor
    Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Learn More
  8. SC 66

    Catalog No. A12081
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    Akt inhibitor
    SC 66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. It exhibits anticancer activity in vitro and in vivo. Learn More
  9. TIC10

    Catalog No. A15903
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    Akt Inhibitor‎
    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2. Learn More
  10. Akt1 and Akt2-IN-1

    Catalog No. A16285
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    AKT 1/2 inhibitor
    Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity. Learn More
  11. ARQ-092 (Miransertib)

    Catalog No. A16286
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    AKT inhibitor
    ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). Learn More
  12. MK-2206 2HCl

    Catalog No. A10003
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    AKT Inhibitor
    MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Learn More
  13. Perifosine (NSC-639966)

    Catalog No. A10709
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    Akt inhibitor
    Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor. Learn More
  14. PF-04691502

    Catalog No. A11024
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    PI3K/mTOR Inhibitor
    PF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway. Learn More
  15. GSK690693

    Catalog No. A11030
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    AKT inhibitor
    GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Learn More
  16. AT7867

    Catalog No. A10094
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    AKT inhibitor
    AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. Learn More
  17. CCT128930

    Catalog No. A11031
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    AKT Inhibitor
    CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. Learn More
  18. PHT-427

    Catalog No. A11032
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    AKT Inhibitor
    PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Learn More
  19. Triciribine phosphate (NSC-280594)

    Catalog No. A11033
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    AKT Inhibitor
    Triciribine phosphate inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Learn More
  20. A-674563

    Catalog No. A11034
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    Akt inhibitor
    A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More
  21. Honokiol

    Catalog No. A10453
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    Antiangiogenic and Antitumor Agent
    Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Learn More
  22. AKT inhibitor VIII (AKTI-1/2)

    Catalog No. A11286
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    AKT inhibitor
    AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). Learn More
  23. A-443654

    Catalog No. A11287
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    Akt inhibitor
    A-443654, a specific Akt inhibitor with Ki value of 160 pM, interferes with mitotic progression and bipolar spindle formation. Learn More
  24. AZD5363

    Catalog No. A11759
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    AKT inhibitor
    AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent. Learn More
  25. KP372-1

    Catalog No. A12877
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    Akt Inhibitor
    KP372-1 is a synthetic small molecule AKT inhibitor. Learn More
  26. Deguelin

    Catalog No. A13460
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    Deguelin is a natural product that displays profound antiproliferative activity. Learn More
  27. Triciribine

    Catalog No. A13210
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    AKT Inhibitor
    Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt. Learn More
  28. Akt-l-1

    Catalog No. A12435
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    AKT1 inhibitor
    Akt-I-1 is a specific inhibitor of Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3 Learn More
  29. AT13148

    Catalog No. A12464
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    multi-AGC kinase inhibitor
    AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. Learn More
  30. Miltefosine

    Catalog No. A14138
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    PI3K/Akt inhibitor
    Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa Learn More
  31. AT7867 2HCl

    Catalog No. A15006
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    Akt inhibitor
    AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. Learn More
  32. Tomatidine

    Catalog No. A16233
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    ERK/Akt/NF-kB inhibitor
    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties. Learn More
  33. Afuresertib

    Catalog No. A16392
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    Akt inhibitor
    Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2. Learn More
  34. VS-5584

    Catalog No. A12480
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    PI3K/mTOR inhibitor
    VS-5584 is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Learn More
  35. HS-173

    Catalog No. A13021
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    PI3K Inhibitor
    HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. Learn More
  36. Panulisib (P7170, AK151761)

    Catalog No. A14379
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    PI3K inhibitor
    Panulisib is a potent and selective imidazoquinoline based PI3K inhibitor with potential anticancer activity. Learn More
  37. AZD8186

    Catalog No. A14164
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    PI3K inhibitor
    AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Learn More
  38. CAL-130

    Catalog No. A15030
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    PI3K inhibitor
    CAL-130 is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3Kδ/γ as therapy for T cell acute lymphoblastic leukemia (T-ALL). Learn More
  39. CAL-130 Hydrochloride

    Catalog No. A15031
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    PI3K inhibitor
    CAL-130 Hydrochloride is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3Kδ/γ as therapy for T cell acute lymphoblastic leukemia (T-ALL). Learn More
  40. LY 303511

    Catalog No. A15147
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    PI3K inhibitor
    LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K. Learn More
  41. NVP-BKM120 Hydrochloride

    Catalog No. A15195
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    PI3K Inhibitor‎
    NVP-BKM120 Hydrochloride is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNA-PK, with little activity to PI4Kβ. Learn More
  42. PI-103 Hydrochloride

    Catalog No. A15212
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    PI3K Inhibitor
    PI103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha (IC50= 2 nM), p110beta (IC50= 3 nM), p110delta (IC50= 3 nM), and p110gamma (IC50= 15 nM), less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. Learn More
  43. XL-147 (Pilaralisib)

    Catalog No. A15283
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    PI3K Inhibitor
    XL147 is a potent, orally bioavailable inhibitor of the class I PI3K family of lipid kinases. Learn More
  44. AZD8186

    Catalog No. A15759
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    PI3K inhibitor
    AZD8186 is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC50=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM). Learn More
  45. Acalisib (GS-9820)

    Catalog No. A14441
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    PI3Kδ Inhibitor
    Acalisib is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. Learn More
  46. AMG319

    Catalog No. A15901
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    PI3Kδ inhibitor
    AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2. Learn More
  47. PF-4989216

    Catalog No. A12889
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    PI3K inhibitor
    PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110??, p110??, p110??, p110??, and VPS34, respectively. Learn More
  48. PQR309

    Catalog No. A15992
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    PI3K inhibitor
    PQR309 is an orally bioavailable pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. Learn More
  49. GNE-317

    Catalog No. A13992
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    PI3K inhibitor
    GNE-317 is a potent PI3K inhibitor that can cross the Blood brain barrier; shows potent suppression of the PI3K pathway in the brain of mice with intact BBB. Learn More
  50. LY3023414

    Catalog No. A16126
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    PI3K/mTOR Dual Inhibitor
    LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242). Learn More

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