PI3K / Akt / mTOR

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  1. MK-2206 2HCl

    Catalog No. A10003
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    AKT Inhibitor
    MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Learn More
  2. Perifosine (NSC-639966)

    Catalog No. A10709
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    Akt inhibitor
    Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor. Learn More
  3. A-674563

    Catalog No. A11034
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    Akt inhibitor
    A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More
  4. AKT inhibitor VIII (AKTI-1/2)

    Catalog No. A11286
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    AKT inhibitor
    AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). Learn More
  5. GSK690693

    Catalog No. A11030
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    AKT inhibitor
    GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Learn More
  6. AZD5363

    Catalog No. A11759
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    AKT inhibitor
    AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent. Learn More
  7. Palomid 529 (P529)

    Catalog No. A10693
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    AKT Inhibitor
    Palomid 529 is a dual TORC1/2 inhibitor of the PI3K/Akt/mTOR pathway having broad activity in angiogenesis and cellular proliferation. Learn More
  8. GDC-0068 (Ipatasertib, RG-7440)

    Catalog No. A11246
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    Akt Inhibitor
    GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays Learn More
  9. TIC10 isomer

    Catalog No. A12720
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    AKT inhibitor‎
    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Learn More
  10. 10-DEBC HCl

    Catalog No. A13590
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    AKT/PKB inhibitor‎
    10-DEBC HCl is a selective inhibitor of Akt/PKB. It inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Learn More
  11. SR-13668

    Catalog No. A13554
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    AKT inhibitor‎
    SR-13668 is an Akt inhibitor, is also an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities. Learn More
  12. Afuresertib HCl

    Catalog No. A13030
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    AKT inhibitor‎
    Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Learn More
  13. SC79

    Catalog No. A15541
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    Akt phosphorylation activator
    SC79 is an AKT activator. SC79 binds to the plecktrin homology (PH) domain of Akt that mimics the binding of PtdIns(3,4,5)P3 to induce a conformational change in Akt that enhances phosphorylation and activation. Learn More
  14. GSK2141795 (Uprosertib, GSK795)

    Catalog No. A15809
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    Akt inhibitor
    Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Learn More
  15. SC 66

    Catalog No. A12081
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    Akt inhibitor
    SC 66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. It exhibits anticancer activity in vitro and in vivo. Learn More
  16. TIC10

    Catalog No. A15903
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    Akt Inhibitor‎
    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2. Learn More
  17. Akt1 and Akt2-IN-1

    Catalog No. A16285
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    AKT 1/2 inhibitor
    Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity. Learn More
  18. ARQ-092 (Miransertib)

    Catalog No. A16286
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    AKT inhibitor
    ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). Learn More
  19. AKT-IN-2

    Catalog No. A20147
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    AKT inhibitor
    AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1. Learn More
  20. BAY1125976

    Catalog No. A20421
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    allosteric Akt1/Akt2 inhibitor
    BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively. Learn More
  21. Miransertib hydrochloride

    Catalog No. A22376
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    Akt inhibitor
    Miransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. Learn More
  22. API-1

    Catalog No. A22093
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    Akt inhibitor
    API-1 (NSC 177223) is a potent inhibitor of Akt that induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis. Learn More
  23. PF-04691502

    Catalog No. A11024
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    PI3K/mTOR Inhibitor
    PF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway. Learn More
  24. AT7867

    Catalog No. A10094
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    AKT inhibitor
    AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. Learn More
  25. CCT128930

    Catalog No. A11031
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    AKT Inhibitor
    CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. Learn More
  26. PHT-427

    Catalog No. A11032
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    AKT Inhibitor
    PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Learn More
  27. Triciribine phosphate (NSC-280594)

    Catalog No. A11033
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    AKT Inhibitor
    Triciribine phosphate inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Learn More
  28. Honokiol

    Catalog No. A10453
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    Antiangiogenic and Antitumor Agent
    Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Learn More
  29. A-443654

    Catalog No. A11287
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    Akt inhibitor
    A-443654, a specific Akt inhibitor with Ki value of 160 pM, interferes with mitotic progression and bipolar spindle formation. Learn More
  30. KP372-1

    Catalog No. A12877
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    Akt Inhibitor
    KP372-1 is a synthetic small molecule AKT inhibitor. Learn More
  31. Deguelin

    Catalog No. A13460
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    Deguelin is a natural product that displays profound antiproliferative activity. Learn More
  32. Triciribine

    Catalog No. A13210
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    AKT Inhibitor
    Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt. Learn More
  33. Akt-l-1

    Catalog No. A12435
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    AKT1 inhibitor
    Akt-I-1 is a specific inhibitor of Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3 Learn More
  34. AT13148

    Catalog No. A12464
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    multi-AGC kinase inhibitor
    AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. Learn More
  35. Miltefosine

    Catalog No. A14138
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    PI3K/Akt inhibitor
    Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa Learn More
  36. AT7867 2HCl

    Catalog No. A15006
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    Akt inhibitor
    AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. Learn More
  37. Tomatidine

    Catalog No. A16233
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    ERK/Akt/NF-kB inhibitor
    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties. Learn More
  38. Afuresertib

    Catalog No. A16392
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    Akt inhibitor
    Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2. Learn More
  39. Borussertib

    Catalog No. A13364
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    Akt inhibitor
    Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. Learn More
  40. AKT Kinase Inhibitor

    Catalog No. A11285
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    Akt kinase inhibitor
    AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity. Learn More
  41. Isobavachalcone

    Catalog No. A11453
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    Akt inhibitor
    Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Learn More
  42. 3CAI

    Catalog No. A20924
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    AKT1/AKT2 inhibitor
    3CAI is a potent and specific AKT1 and AKT2 inhibitor. Learn More
  43. Solenopsin

    Catalog No. A21087
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    ATP-competitive AKT inhibitor
    Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM . Learn More
  44. YS-49

    Catalog No. A21198
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    PI3K/Akt activator
    YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. Learn More
  45. Ipatasertib dihydrochloride

    Catalog No. A21734
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    pan-Akt inhibitor
    Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. Learn More
  46. PF-AKT400

    Catalog No. A21991
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    Akt inhibitor
    PF-AKT400 is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM). Learn More
  47. AKT-IN-1

    Catalog No. A21009
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    AKT inhibitor
    AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. Learn More
  48. BKM120 (NVP-BKM120, Buparlisib)

    Catalog No. A11016
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    PI3K Inhibitor‎
    BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. Learn More
  49. NU-7441 (KU-57788)

    Catalog No. A11098
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    DNA-PK inhibitor
    NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively. Learn More
  50. BEZ235 (NVP-BEZ235, Dactolisib)

    Catalog No. A10133
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    PI3K/mTOR Inhibitor
    BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Learn More

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