BGJ398 (NVP-BGJ398)

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FGFR Inhibitor

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Catalog No. A11159

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BGJ398 (NVP-BGJ398) 5mg A11159-5

Regular Price: $50.00

Special Price: $40.00

BGJ398 (NVP-BGJ398) 10mg A11159-10

Regular Price: $70.00

Special Price: $56.00

BGJ398 (NVP-BGJ398) 50mg A11159-50

Regular Price: $140.00

Special Price: $112.00

BGJ398 (NVP-BGJ398) 100mg A11159-100

Regular Price: $240.00

Special Price: $192.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively).

BGJ398 (NVP-BGJ398)

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Chemical Information

Catalog Num A11159
Actions Inhibitor
M. Wt 560.48
Formula C26H31Cl2N7O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 872511-34-7
Synonyms BGJ-398
SMILES code CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl
Chemical Name 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea

Biological Activity

Description
BGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively).
Targets
Target Value
FGFR1IC50: 0.9nM
FGFR3IC50: 1.0nM
FGFR2IC50: 1.4nM
FGFR3(K650E)IC50: 4.9nM
FGFR4IC50: 60nM
VEGFR2IC50: 0.18μM
LynIC50: 0.30μM
KitIC50: 0.75μM
YESIC50: 1.1μM
FynIC50: 1.9μM
AblIC50: 2.3μM
LCKIC50: 2.5μM

Solubility

Solubility (25°C) * In vitro DMSO 1 mg/mL heating (1.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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