BGJ398 (NVP-BGJ398)

BGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively).
Grouped product items
Product Name Price Stock Qty
BGJ398 (NVP-BGJ398) 5mg
$50.00
In stock
BGJ398 (NVP-BGJ398) 10mg
$70.00
In stock
BGJ398 (NVP-BGJ398) 50mg
$140.00
In stock
BGJ398 (NVP-BGJ398) 100mg
$240.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's BGJ398 (NVP-BGJ398) has been cited by 4 publications
  • Takehito Yamamoto, .et al. , Cancers (Basel), 2020, Jul 22;12(8):E2010 PMID: 32708005
  • Daniel Limonta, .et al. , J Infect Dis, 2019, 2019 PMID: 30799482
  • Li Li, .et al. , Leukemia Res, 2019, 78:12-20 PMID: 30660961
  • Anil Kumar, .et al. , Sci Rep, 2018, 8: 5477 PMID: 29615760
  • Biological Activity
    Discription BGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively).
    Targets
    Target Value
    Product Information
    Catalog Num A11159
    Formula C26H31Cl2N7O3
    Molecular Weight 560.48
    CAS Number 872511-34-7
    SMILES CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl
    Synonyms BGJ-398
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 1 mg/mL (1.78 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 1%CMC-Na 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 17.84 mL 89.21 mL 178.42 mL
    0.5 mM 3.57 mL 17.84 mL 35.68 mL
    1 mM 1.78 mL 8.92 mL 17.84 mL
    5 mM 0.36 mL 1.78 mL 3.57 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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