NVP-BGJ398 phosphate

Catalog No.: A15194

FGFR Inhibitor

NVP-BGJ398 phosphate

NVP-BGJ398 phosphate Chemical Structure

CAS NO. 1310746-10-1

NVP-BGJ398 phosphate is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$90.00
50 mg
$240.00
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Biological Activity

NVP-BGJ398 phosphate is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.19 mL 75.93 mL 151.87 mL
0.5 mM 3.04 mL 15.19 mL 30.37 mL
1 mM 1.52 mL 7.59 mL 15.19 mL
5 mM 0.3 mL 1.52 mL 3.04 mL

*The above data is based on the productmolecular weight 658.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15194
Actions Inhibitor
CAS No. 1310746-10-1
Formula C26H34Cl2N7O7P
M. Wt 658.47
Solubility DMSO
Purity >98%
Synonyms BGJ-398 phosphate, BGJ 398 phosphate, NVP BGJ398 phosphate
SMILES CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl.OP(=O)(O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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