BI 2536

Catalog No.: A10134
PLK inhibitor
BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.
Grouped product items
Product Name Price Stock Qty
BI 2536 5mg
$70.00
In stock
BI 2536 10mg
$120.00
In stock
BI 2536 50mg
$320.00
In stock
BI 2536 100mg
$580.00
In stock
BI 2536 10mM * 1mL in DMSO
$132.00
In stock
Bulk Size
Bulk Discount
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's BI 2536 has been cited by 10 publications
  • Nuria Gallisa-Sune, .et al. , Nat Commun, 2023, Apr 27;14(1):2434 PMID: 37105961
  • Kei K Ito, .et al. , J Cell Biol, 2021, Mar 1;220(3):e202005153 PMID: 33492359
  • Ryuzaburo Yuki, .et al. , J Cell Mol Med, 2021, Feb;25(3):1677-1687 PMID: 33465289
  • Yamagishi A, .et al. , Int J Mol Sci, 2020, Feb 5;21(3) PMID: 32033461
  • Bucko PJ, .et al. , Elife, 2019, Dec 24;8. pii: e52220 PMID: 31872801
  • Watanabe K, .et al. , Nat Commun, 2019, Feb 25;10(1):931 PMID: 30804344
  • Valérian Pasche, .et al. , Parasit Vectors, 2018, 11: 298 PMID: 29764454
  • Takeshi Wakida, .et al. , eLife, 2017, 6: e29953 PMID: 29254517
  • Majid Momeny, .et al. , Sci Rep, 2017, 7: 4204 PMID: 28646172
  • Ifuji A, .et al. , Exp Cell Res, 2017, Nov 15;360(2):347-357 PMID: 28942021
  • Biological Activity
    Discription BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.
    Targets
    Target Value
    Product Information
    Catalog Num A10134
    Formula C28H39N7O3
    Molecular Weight 521.7
    CAS Number 755038-02-9
    SMILES CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 21 mg/mL (40.25 mM)
    Water Insoluble
    Ethanol 98 mg/mL (187.86 mM)
    In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.17 mL 95.84 mL 191.68 mL
    0.5 mM 3.83 mL 19.17 mL 38.34 mL
    1 mM 1.92 mL 9.58 mL 19.17 mL
    5 mM 0.38 mL 1.92 mL 3.83 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

      Concentration

      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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      C2

      V2

    • Calculator Reset
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