BI 2536

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PLK inhibitor

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Catalog No. A10134

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BI 2536 5mg A10134-5

Regular Price: $70.00

Special Price: $59.50

BI 2536 10mg A10134-10

Regular Price: $120.00

Special Price: $102.00

BI 2536 50mg A10134-50

Regular Price: $320.00

Special Price: $272.00

BI 2536 100mg A10134-100

Regular Price: $580.00

Special Price: $493.00

BI 2536 10mM * 1mL in DMSO A10134-10mM-D

Regular Price: $132.00

Special Price: $112.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.

BI 2536

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Chemical Information

Catalog Num A10134
Actions Inhibitor
M. Wt 521.7
Formula C28H39N7O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 755038-02-9
Synonyms BI2536, BI-2536
SMILES code CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C
Chemical Name 4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide

Biological Activity

Description
BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.
Targets
Target Value
PLK1IC50: 0.83nM
PLK2IC50: 3.5nM
PLK3IC50: 9.0nM
PI3KαIC50: 2.407μM
MetIC50: 4.754μM
Tie-2IC50: 6.549μM
HGFRIC50: 9.5μM
ErbB4IC50: 9.908μM
AblIC50: >10μM
AxlIC50: >10μM
AMPKIC50: >10μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
βIRKIC50: >10μM
B-RafIC50: >10μM
BTKIC50: >10μM
CDK1/CyclinB1IC50: >10μM
CDK2/CyclinEIC50: >10μM
Chk1IC50: >10μM
CK1IC50: >10μM
CK2IC50: >10μM
C-RafIC50: >10μM
CSKIC50: >10μM
DYRK1AIC50: >10μM
ECKIC50: >10μM
ERK2IC50: >10μM
FGFR1IC50: >10μM
FGFR3IC50: >10μM
FLT1IC50: >10μM
FLT3IC50: >10μM
GSK-3βIC50: >10μM
HekIC50: >10μM
HER2IC50: >10μM
ITKIC50: >10μM
JAK2IC50: >10μM
JAK3IC50: >10μM
JNK1IC50: >10μM
LCKIC50: >10μM
LynIC50: >10μM
MAPKAPK2IC50: >10μM
MEK1IC50: >10μM
MSK1IC50: >10μM
MKK1IC50: >10μM
NEK6IC50: >10μM
p38αIC50: >10μM
p38βIC50: >10μM
p38γIC50: >10μM
p38δIC50: >10μM
PAK2IC50: >10μM
PDGFRαIC50: >10μM
PDGFRβIC50: >10μM
PDK-1IC50: >10μM
PKAIC50: >10μM
PKBαIC50: >10μM
PKBβIC50: >10μM
PKCαIC50: >10μM
PRAKIC50: >10μM
RETIC50: >10μM
ROCK2IC50: >10μM
RONIC50: >10μM
S6KIC50: >10μM
SGKIC50: >10μM
SrcIC50: >10μM
SykIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 21 mg/mL (40.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (191.69 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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