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BI-D1870

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S6 Kinase inhibitor

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Catalog No. A12452

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BI-D1870 5mg A12452-5

Regular Price: $110.00

Special Price: $99.00

BI-D1870 10mg A12452-10

Regular Price: $190.00

Special Price: $171.00

BI-D1870 25mg A12452-25

Regular Price: $340.00

Special Price: $306.00

BI-D1870 50mg A12452-50

Regular Price: $530.00

Special Price: $477.00

BI-D1870 10mM * 1mL in DMSO A12452-10mM-D

Regular Price: $110.00

Special Price: $99.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BI-D1870 is a potent and specific inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms in vitro and in vivo, which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10–30 nM.

BI-D1870

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Chemical Information

Catalog Num A12452
Actions Inhibitor
M. Wt 391.41
Formula C19H23F2N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 501437-28-1
Synonyms N/A
SMILES code CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C
Chemical Name 2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone

Biological Activity

Description
BI-D1870 is a potent and specific inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms in vitro and in vivo, which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10–30 nM.
Targets
RSK4 (Cell-free assay) RSK3 (Cell-free assay) RSK2 (Cell-free assay) RSK1 (Cell-free assay)
15 nM18 nM24 nM31 nM

Solubility

Solubility (25°C) * In vitro DMSO 78 mg/mL (199.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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