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BMY 7378

Name: BMY 7378
Brand: Adooq Bioscience
SKU: A11208
Availability: InStock

Cat. No. A11208 CAS 21102-95-4

5-HT1A agonist

BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist.

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Biological Activity

Target & Activity

Target	Activity	Value
5-HT1A	pIC50	8.3
α1D-adrenoceptor	pki	8.2
DopamineD2receptor	pIC50	7.4
α2C-adrenoceptor	pki	6.54
5-HT1C	pIC50	6.4
5-HT1D	pIC50	5.9
H1receptor	pIC50	5.7
5-HT2	pIC50	5.5
H2receptor	pIC50	5.3
α2-adrenoceptor	pIC50	5.1
β1-adrenoceptor	pIC50	5.1
DopamineD1receptor	pIC50	5
Nicotinicreceptor	pIC50	4.9
β2-adrenoceptor	pIC50	<5.0
5-HT3	pIC50	<5.0
H3receptor	pIC50	<5.0
GABAAreceptor	pIC50	<5.0
GABABreceptor	pIC50	<5.0
MuscarinicM1receptor	pIC50	<5.0
MuscarinicM2receptor	pIC50	<5.0
MuscarinicM3receptor	pIC50	<5.0
NMDAreceptor	pIC50	<5.0
AT1receptor	pIC50	<5.0
AT2receptor	pIC50	<5.0
EndothelinReceptor	pIC50	<5.0
AdenosineA1receptor	pIC50	<5.0
AdenosineA2receptor	pIC50	<5.0

27 targets · Scroll to view more

Specifications

Manufacturer	Adooq Bioscience
Actions	Partial Agonist
CAS Number	21102-95-4
Applications	5-HT1A agonist
Formula	C₂₂H₃₁N₃O₃.2HCl
Molecular Weight	458.42
SMILES	COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O.Cl.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	81 mg/mL (176.69 mM)
Water	81 mg/mL (176.69 mM)
Ethanol	18 mg/mL (39.26 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration: 14 mg/mL
Vehicle: Saline

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.