BMY 7378

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5-HT1A agonist

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Catalog No. A11208

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BMY 7378 10mg A11208-10

Regular Price: $40.00

Special Price: $34.00

BMY 7378 50mg A11208-50

Regular Price: $85.00

Special Price: $72.25

BMY 7378 200mg A11208-200

Regular Price: $320.00

Special Price: $272.00

BMY 7378 10mM * 1mL in DMSO A11208-10mM-D

Regular Price: $77.00

Special Price: $65.45

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist.

BMY 7378

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Chemical Information

Catalog Num A11208
Actions Agonist
M. Wt 458.42
Formula C22H31N3O3.2HCl
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 21102-95-4
Synonyms BMY7378, BMY-7378
SMILES code COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O.Cl.Cl
Chemical Name 8-[2-[4-(methoxyphenyl)-1-piperazin yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride

Biological Activity

Description
BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist.
Targets
Target Value
5-HT1ApIC50: 8.3
α1D-adrenoceptorpki: 8.2
DopamineD2receptorpIC50: 7.4
α2C-adrenoceptorpki: 6.54
5-HT1CpIC50: 6.4
5-HT1DpIC50: 5.9
H1receptorpIC50: 5.7
5-HT2pIC50: 5.5
H2receptorpIC50: 5.3
α2-adrenoceptor pIC50: 5.1
β1-adrenoceptor pIC50: 5.1
DopamineD1receptorpIC50: 5
NicotinicreceptorpIC50: 4.9
β2-adrenoceptor pIC50: <5.0
5-HT3pIC50: <5.0
H3receptorpIC50: <5.0
GABAAreceptorpIC50: <5.0
GABABreceptorpIC50: <5.0
MuscarinicM1receptorpIC50: <5.0
MuscarinicM2receptorpIC50: <5.0
MuscarinicM3receptorpIC50: <5.0
NMDAreceptorpIC50: <5.0
AT1receptorpIC50: <5.0
AT2receptorpIC50: <5.0
EndothelinReceptorpIC50: <5.0
AdenosineA1receptorpIC50: <5.0
AdenosineA2receptorpIC50: <5.0

Solubility

Solubility (25°C) * In vitro DMSO 92 mg/mL (200.68 mM)
Water 92 mg/mL (200.68 mM)
Ethanol 20 mg/mL (43.62 mM)
In vivo Saline 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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