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5-HT1D receptor antagonist

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Catalog No. A11178
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Product Name Catalog No. Price
BRL-15572 5mg A11178-5
BRL-15572 10mg A11178-10
BRL-15572 50mg A11178-50
BRL-15572 100mg A11178-100
BRL-15572 10mM * 1mL in DMSO A11178-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BRL-15572 is a selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.


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Chemical Information

Catalog Num A11178
Actions Antagonist
M. Wt 443.42
Formula C25H27ClN2O.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 193611-72-2
Synonyms BRL15572
Chemical Name 3-[4-(4-Chlorophenyl)piperazin-1-yl ]-1,1-diphenyl-2-propanol hydrochloride

Biological Activity


BRL-15572 is a selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.

Target Value
5-HT1Dpki: 7.9
5-HT1Apki: 7.7
5-HT2Bpki: 7.4
5-HT2Apki: 6.6
5-HT7pki: 6.3
5-HT2Cpki: 6.2
5-HT1Bpki: 6.1
5-HT1Fpki: 6
5-HT6pki: 5.9
5-HT1Epki: 5.2


Solubility (25°C) * In vitro DMSO 96 mg/mL (200.05 mM)
Water <1 mg/mL (<1 mM)
Ethanol 40 mg/mL (83.35 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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