Canagliflozin

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SGLT2 Inhibitor

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Catalog No. A11100

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Canagliflozin 5mg A11100-5

Regular Price: $50.00

Special Price: $42.50

Canagliflozin 10mg A11100-10

Regular Price: $70.00

Special Price: $59.50

Canagliflozin 50mg A11100-50

Regular Price: $150.00

Special Price: $127.50

Canagliflozin 100mg A11100-100

Regular Price: $200.00

Special Price: $170.00

Canagliflozin 10mM * 1mL in DMSO A11100-10mM-D

Regular Price: $55.00

Special Price: $46.75

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2).

Canagliflozin

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Chemical Information

Catalog Num A11100
Actions Inhibitor
M. Wt 444.5
Formula C24H25FO5S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 842133-18-0
Synonyms N/A
SMILES code CC1=C(C=C(C=C1)[[email protected]]2[C@@H]([[email protected]]([C@@H]([[email protected]](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F
Chemical Name (2S,3R,4R,5S,6R)-2-{3-[5-[4-Fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

Biological Activity

Description
Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2).
Targets
mSGLT2 (Cell-free assay) rSGLT2 (Cell-free assay) hSGLT2 (Cell-free assay)
2 nM3.7 nM4.4 nM

Solubility

Solubility (25°C) * In vitro DMSO 88 mg/mL (197.96 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80 18 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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