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$0.00 Membrane Transporters/Ion Channels
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Brefeldin A
Catalog No. A11156 Protein translocation InhibitorBrefeldin A blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange. Learn More -
PF 3716556
Catalog No. A11408 ATPase antagonistPF 3716556 is H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays). Learn More -
Sodium orthovanadate
Catalog No. A10854 protein tyrosine phosphatases inhibitorSodium orthovanadate is the chemical compound Na3VO4. It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. Learn More -
Artemisinin
Catalog No. A10086 Artemisinin and its derivatives are a group of drugs that possess the most rapid action of all current drugs against Plasmodium falciparum malaria. Learn More -
Ciclopirox
Catalog No. A10213 Ciclopirox is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic dermatitis as it suppresses growth of the yeast Malassezia furfur.It acts by inhibiting the membrane transfer system by interrupting the Na+ K+ ATPase. Learn More -
Pantoprazole (Protonix)
Catalog No. A11696 Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion. Learn More -
Bafilomycin A1
Catalog No. A11961 ATPase inhibitorBafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Learn More -
Bufalin
Catalog No. A12022 Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively. Anti-cancer activity. Learn More -
Bufotalin
Catalog No. A12024 Bufotalin is a less potent Na+/K+-ATPase inhibitor than other bufadienolides. Potent immunosuppressor. Learn More -
Cinobufagin
Catalog No. A12032 Cinobufagin is a specific Na+/K+-ATPase inhibitor. About as active as ouabain Learn More -
Ouabain
Catalog No. A12755 a-K-ATPase inhibitorOuabain is a selective Na+, K+-ATPase inhibitor. Learn More -
Oligomycin A
Catalog No. A10669 ATPase inhibitorOligomycin A is a mitochondrial ATPase inhibitor. Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. Learn More -
Omeprazole
Catalog No. A10672 ATPase InhibitorsOmeprazole is a cell-permeable, selective proton pump inhibitor. Learn More -
PST-2744 (Istaroxime)
Catalog No. A13041 Istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Learn More -
Rostafuroxin (PST-2238)
Catalog No. A13283 Na+/K+ ATPase modulatorRostafuroxin (PST-2238) is an ouabain-inhibitor counteracting specific forms of hypertension. Learn More -
(-)-Blebbistcitin
Catalog No. A13647 myosin II inhibitorBlebbistatin, a myosin II inhibitor, is photoinactivated by blue light. Learn More -
BTB06584
Catalog No. A14308 F1 Fo-ATPase inhibitorBTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. Learn More -
Melittin
Catalog No. A13912 Na+/K+ ATPase inhibitorMelittin is a Na+/K+ ATPase inhibitor. It inhibits Gs and stimulates Gi activity. It inhibits protein kinase C and cAMP-dependent protein kinases. Learn More -
Oligomycin
Catalog No. A14000 ATP synthase inhibitorOligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. Learn More -
Cyclopiazonic Acid
Catalog No. A14002 SERCA inhibitorCyclopiazonic acid is an inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase) which induces the release of intracellular stored Ca2+, without increasing IP3 levels. Learn More -
Glucagon (19-29), human
Catalog No. A14875 Ca 2+ /Mg 2+ -ATPase inhibitorGlucagon (19-29) (human) is a potent Ca 2+ /Mg 2+ -ATPase inhibitor. Learn More -
PTC124 (Ataluren)
Catalog No. A10758 CFTR inhibitorPTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor. Learn More -
VX-770 (Ivacaftor)
Catalog No. A10985 CFTR activatorVX-770 (Ivacaftor) is known as a CFTR potentiator. Learn More -
VX-809 (Lumacaftor)
Catalog No. A10986 CFTR modulatorVX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF). Learn More -
VX-661
Catalog No. A12519 CFTR correctorVX-661 is another cystic fibrosis transmembrane conductance regulator (CFTR) corrector in development for the treatment of cystic fibrosis. Learn More -
Glyburide
Catalog No. A10433 -
CFTR-Inhibitor-II
Catalog No. A13723 CFTR inhibitorCFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 uM). Learn More -
PPQ-102
Catalog No. A13000 CFTR chloride channel inhibitorPPQ-102 is a compound that targets intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR- mediated chloride current in a voltage-dependent and reversible manner. Learn More -
Oridonin (Isodonol)
Catalog No. A10675 CFTR InhibitorOridonin (Isodonol), an entkaurane diterpenoid isolated from Rabdosia rubescens, is an important traditional Chinese herbal remedy. Learn More -
CFTRinh-172
Catalog No. A12897 CFTR inhibitorCFTRinh-172 is a voltage-independent, selective CFTR inhibitor Learn More -
KM 11060
Catalog No. A15843 F508del-CFTR trafficking correctorKM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity Learn More -
PG 01
Catalog No. A18315 CFTR potentiatorPG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. PG 01 is effective on G970R although with a significant decrease in potency relative to E193K and δF508. Learn More -
CFTR corrector 2
Catalog No. A18528 CFTR correctorCFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933. Learn More -
GLPG2451
Catalog No. A18919 CFTR potentiatorGLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM. Learn More -
Ivacaftor benzenesulfonate
Catalog No. A15132 CFTR potentiatorIvacaftor benzenesulfonate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment. Learn More -
Ivacaftor hydrate
Catalog No. A15133 CFTR potentiatorIvacaftor hydrate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment. Learn More -
Caldaret
Catalog No. A13148 intracellular Ca2+ handling modulatorCaldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition. Learn More -
ABT-639 hydrochloride
Catalog No. A12571 T-type Ca2+ channel blockerABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker. Learn More -
(S)-(-)-Bay-K-8644
Catalog No. A21164 L-type Ca2+ channel agonist(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM). Learn More -
TTA-Q6
Catalog No. A21360 T-type Ca2+ channel antagonistTTA-Q6 is a selective T-type Ca2+ channel antagonist, used in the neurological disease. Learn More -
TTA-Q6(isomer)
Catalog No. A21724 T-type Ca2+ channel antagonistTTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca2+ channel antagonist. Learn More -
JTV-519 free base
Catalog No. A21846 Ca2+-dependent blockerTV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties. Learn More -
GV-58
Catalog No. A21966 N- and P/Q-type Ca2+ channels agonistGV-58 is a potent, selective N- and P/Q-type Ca2+ channels agonist with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel; 20-fold less potent CDK inhibitor activity. Learn More -
Tetrandrine (Fanchinine)
Catalog No. A10921 Calcium Channel inhibitorTetrandrine is a calcium channel blocker. It inhibits the degranulation of mast cells.Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis. Learn More -
Astragaloside A
Catalog No. A11405 Ca2+ signaling modulatorAstragaloside A is a novel regulator of HIF-1α and angiogenesis through the PI3K/Akt pathway in HUVECs that are exposed to hypoxia. Learn More -
CK-1827452 (Omecamtiv mecarbil)
Catalog No. A11206 Myosin activatorCK-1827452 is a selective cardiac specific myosin activator. Learn More -
Manidipine 2HCl
Catalog No. A10554 Manidipine 2HCl is a HCl salt form of Manidipine which is a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. Learn More -
Amlodipine
Catalog No. A10068 L-type calcium channel blockerAmlodipin is L-type calcium channel blocker that displays antihypertensive properties. It inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Learn More
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