Membrane Transporters/Ion Channels

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  1. Brefeldin A

    Catalog No. A11156
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    Protein translocation Inhibitor
    Brefeldin A blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange. Learn More
  2. PF 3716556

    Catalog No. A11408
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    ATPase antagonist
    PF 3716556 is H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays). Learn More
  3. Sodium orthovanadate

    Catalog No. A10854
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    Sodium orthovanadate is the chemical compound Na3VO4. It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. Learn More
  4. Artemisinin

    Catalog No. A10086
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    Artemisinin and its derivatives are a group of drugs that possess the most rapid action of all current drugs against Plasmodium falciparum malaria. Learn More
  5. Ciclopirox

    Catalog No. A10213
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    Ciclopirox is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic dermatitis as it suppresses growth of the yeast Malassezia furfur.It acts by inhibiting the membrane transfer system by interrupting the Na+ K+ ATPase. Learn More
  6. Pantoprazole (Protonix)

    Catalog No. A11696
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    Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion. Learn More
  7. Bafilomycin A1

    Catalog No. A11961
    ATPase inhibitor
    Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Learn More
  8. Bufalin

    Catalog No. A12022
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    Bufalin is a cardiotonic steroid originally isolated from the Chinese toad venom. Learn More
  9. Resibufogenin

    Catalog No. A12023
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    Resibufogenin is a specific Na+/K+-ATPase inhibitor. Learn More
  10. Bufotalin

    Catalog No. A12024
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    Bufotalin is a less potent Na+/K+-ATPase inhibitor than other bufadienolides. Potent immunosuppressor. Learn More
  11. Cinobufagin

    Catalog No. A12032
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    Cinobufagin is a specific Na+/K+-ATPase inhibitor. About as active as ouabain Learn More
  12. Ouabain

    Catalog No. A12755
    a-K-ATPase inhibitor
    Ouabain is a selective Na+, K+-ATPase inhibitor. Learn More
  13. Oligomycin A

    Catalog No. A10669
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    ATPase inhibitor
    Oligomycin A is a mitochondrial ATPase inhibitor. Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. Learn More
  14. Omeprazole

    Catalog No. A10672
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    ATPase Inhibitors
    Omeprazole is a cell-permeable, selective proton pump inhibitor. Learn More
  15. PST-2744 (Istaroxime)

    Catalog No. A13041
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    Istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Learn More
  16. Rostafuroxin (PST-2238)

    Catalog No. A13283
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    Na+/K+ ATPase modulator
    Rostafuroxin (PST-2238) is an ouabain-inhibitor counteracting specific forms of hypertension. Learn More
  17. (-)-Blebbistcitin

    Catalog No. A13647
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    myosin II inhibitor
    Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light. Learn More
  18. BTB06584

    Catalog No. A14308
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    F1 Fo-ATPase inhibitor
    BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. Learn More
  19. Melittin

    Catalog No. A13912
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    Na+/K+ ATPase inhibitor
    Melittin is a Na+/K+ ATPase inhibitor. It inhibits Gs and stimulates Gi activity. It inhibits protein kinase C and cAMP-dependent protein kinases. Learn More
  20. Oligomycin

    Catalog No. A14000
    ATP synthase inhibitor
    Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. Learn More
  21. Cyclopiazonic Acid

    Catalog No. A14002
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    SERCA inhibitor
    Cyclopiazonic acid is an inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase) which induces the release of intracellular stored Ca2+, without increasing IP3 levels. Learn More
  22. Thapsigargin

    Catalog No. A14007
    SERCA ATPase inhibitor
    Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50=30 nM). Learn More
  23. Glucagon (19-29), human

    Catalog No. A14875
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    Ca 2+ /Mg 2+ -ATPase inhibitor
    Glucagon (19-29) (human) is a potent Ca 2+ /Mg 2+ -ATPase inhibitor. Learn More
  24. PTC124 (Ataluren)

    Catalog No. A10758
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    CFTR inhibitor
    PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor. Learn More
  25. VX-770 (Ivacaftor)

    Catalog No. A10985
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    CFTR activator
    VX-770 (Ivacaftor) is known as a CFTR potentiator. Learn More
  26. VX-809 (Lumacaftor)

    Catalog No. A10986
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    CFTR modulator
    VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF). Learn More
  27. VX-661

    Catalog No. A12519
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    CFTR corrector
    VX-661 is another cystic fibrosis transmembrane conductance regulator (CFTR) corrector in development for the treatment of cystic fibrosis. Learn More
  28. IOWH032

    Catalog No. A13511
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    CFTR inhibitor
    IOWH032 is a CFTR inhibitor. Learn More
  29. CFTR-Inhibitor-II

    Catalog No. A13723
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    CFTR inhibitor
    CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 uM). Learn More
  30. PPQ-102

    Catalog No. A13000
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    CFTR chloride channel inhibitor
    PPQ-102 is a compound that targets intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR- mediated chloride current in a voltage-dependent and reversible manner. Learn More
  31. Oridonin (Isodonol)

    Catalog No. A10675
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    CFTR Inhibitor
    Oridonin (Isodonol), an entkaurane diterpenoid isolated from Rabdosia rubescens, is an important traditional Chinese herbal remedy. Learn More
  32. CFTRinh-172

    Catalog No. A12897
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    CFTR inhibitor
    CFTRinh-172 is a voltage-independent, selective CFTR inhibitor Learn More
  33. KM 11060

    Catalog No. A15843
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    F508del-CFTR trafficking corrector
    KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity Learn More
  34. Tetrandrine (Fanchinine)

    Catalog No. A10921
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    Calcium Channel inhibitor
    Tetrandrine is a calcium channel blocker. It inhibits the degranulation of mast cells.Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis. Learn More
  35. Astragaloside A

    Catalog No. A11405
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    Ca2+ signaling modulator
    Astragaloside A is a novel regulator of HIF-1α and angiogenesis through the PI3K/Akt pathway in HUVECs that are exposed to hypoxia. Learn More
  36. CK-1827452 (Omecamtiv mecarbil)

    Catalog No. A11206
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    Myosin activator
    CK-1827452 is a selective cardiac specific myosin activator. Learn More
  37. Manidipine 2HCl

    Catalog No. A10554
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    Manidipine 2HCl is a HCl salt form of Manidipine which is a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. Learn More
  38. Amlodipine

    Catalog No. A10068
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    L-type calcium channel blocker
    Amlodipin is L-type calcium channel blocker that displays antihypertensive properties. It inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Learn More
  39. Amlodipine besylate (Norvasc)

    Catalog No. A10069
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    L-type calcium channel blocker
    Amlodipine-besylate is L-type calcium channel blocker that displays antihypertensive properties. It inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Learn More
  40. Cilnidipine

    Catalog No. A10215
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    Calcium channel blocker
    Cilnidipine is a dual blocker of L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply. Learn More
  41. Isradipine

    Catalog No. A10487
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    calcium channel blocker
    Isradipine is a calcium channel blocker of the dihydropyridine class. Learn More
  42. Azelnidipine

    Catalog No. A11219
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    calcium channel blocker
    Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. that attenuates liver fibrosis and may increase antioxidant defence. Learn More
  43. Lacidipine

    Catalog No. A11729
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    Lacidipine is a calcium channel blocker Learn More
  44. Benidipine hydrochloride

    Catalog No. A11730
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    Benidipine hydrochloride is a long-acting T-type calcium channel blocker, on blood pressure and renal function in hypertensive patients with diabetes mellitus. Learn More
  45. Nilvadipine (ARC029)

    Catalog No. A11731
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    calcium channel blocker
    Nilvadipine is a calcium channel blocker (CCB) used for the treatment of hypertension and chronic major cerebral artery occlusion Learn More
  46. Clevidipine

    Catalog No. A11746
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    Calcium channel blocker
    Clevidipine is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable. Learn More
  47. Diethylstilbestrol

    Catalog No. A10309
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    Diethylstilbestrol is a synthetic nonsteroidal estrogen that was first synthesized in 1938. It is also classified as an endocrine disruptor. Learn More
  48. Diltiazem HCl

    Catalog No. A10311
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    Diltiazem is a nondihydropyridine (non-DHP) member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. Learn More
  49. Manidipine (Manyper)

    Catalog No. A10553
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    Manidipine is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. Learn More
  50. Pinaverium Bromide

    Catalog No. A12684
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    Pinaverium Bromide is a spasmolytic agent with low incidence of anticholinergic effects. Pinaverium Bromide is also an antispasmodic. Learn More

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