Membrane Transporters/Ion Channels

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  1. Brefeldin A

    Catalog No. A11156
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    Protein translocation Inhibitor
    Brefeldin A blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange. Learn More
  2. PF 3716556

    Catalog No. A11408
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    ATPase antagonist
    PF 3716556 is H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays). Learn More
  3. Sodium orthovanadate

    Catalog No. A10854
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    protein tyrosine phosphatases inhibitor
    Sodium orthovanadate is the chemical compound Na3VO4. It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. Learn More
  4. Artemisinin

    Catalog No. A10086
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    Artemisinin and its derivatives are a group of drugs that possess the most rapid action of all current drugs against Plasmodium falciparum malaria. Learn More
  5. Ciclopirox

    Catalog No. A10213
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    Ciclopirox is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic dermatitis as it suppresses growth of the yeast Malassezia furfur.It acts by inhibiting the membrane transfer system by interrupting the Na+ K+ ATPase. Learn More
  6. Pantoprazole (Protonix)

    Catalog No. A11696
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    Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion. Learn More
  7. Bafilomycin A1

    Catalog No. A11961
    ATPase inhibitor
    Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Learn More
  8. Bufalin

    Catalog No. A12022
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    Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively. Anti-cancer activity. Learn More
  9. Resibufogenin

    Catalog No. A12023
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    Resibufogenin is a specific Na+/K+-ATPase inhibitor. Learn More
  10. Bufotalin

    Catalog No. A12024
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    Bufotalin is a less potent Na+/K+-ATPase inhibitor than other bufadienolides. Potent immunosuppressor. Learn More
  11. Cinobufagin

    Catalog No. A12032
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    Cinobufagin is a specific Na+/K+-ATPase inhibitor. About as active as ouabain Learn More
  12. Ouabain

    Catalog No. A12755
    a-K-ATPase inhibitor
    Ouabain is a selective Na+, K+-ATPase inhibitor. Learn More
  13. Oligomycin A

    Catalog No. A10669
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    ATPase inhibitor
    Oligomycin A is a mitochondrial ATPase inhibitor. Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. Learn More
  14. Omeprazole

    Catalog No. A10672
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    ATPase Inhibitors
    Omeprazole is a cell-permeable, selective proton pump inhibitor. Learn More
  15. PST-2744 (Istaroxime)

    Catalog No. A13041
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    Istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Learn More
  16. Rostafuroxin (PST-2238)

    Catalog No. A13283
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    Na+/K+ ATPase modulator
    Rostafuroxin (PST-2238) is an ouabain-inhibitor counteracting specific forms of hypertension. Learn More
  17. (-)-Blebbistcitin

    Catalog No. A13647
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    myosin II inhibitor
    Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light. Learn More
  18. BTB06584

    Catalog No. A14308
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    F1 Fo-ATPase inhibitor
    BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. Learn More
  19. Melittin

    Catalog No. A13912
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    Na+/K+ ATPase inhibitor
    Melittin is a Na+/K+ ATPase inhibitor. It inhibits Gs and stimulates Gi activity. It inhibits protein kinase C and cAMP-dependent protein kinases. Learn More
  20. Oligomycin

    Catalog No. A14000
    ATP synthase inhibitor
    Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. Learn More
  21. Cyclopiazonic Acid

    Catalog No. A14002
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    SERCA inhibitor
    Cyclopiazonic acid is an inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase) which induces the release of intracellular stored Ca2+, without increasing IP3 levels. Learn More
  22. Thapsigargin

    Catalog No. A14007
    SERCA ATPase inhibitor
    Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50=30 nM). Learn More
  23. Glucagon (19-29), human

    Catalog No. A14875
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    Ca 2+ /Mg 2+ -ATPase inhibitor
    Glucagon (19-29) (human) is a potent Ca 2+ /Mg 2+ -ATPase inhibitor. Learn More
  24. PTC124 (Ataluren)

    Catalog No. A10758
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    CFTR inhibitor
    PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor. Learn More
  25. VX-770 (Ivacaftor)

    Catalog No. A10985
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    CFTR activator
    VX-770 (Ivacaftor) is known as a CFTR potentiator. Learn More
  26. VX-809 (Lumacaftor)

    Catalog No. A10986
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    CFTR modulator
    VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF). Learn More
  27. VX-661

    Catalog No. A12519
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    CFTR corrector
    VX-661 is another cystic fibrosis transmembrane conductance regulator (CFTR) corrector in development for the treatment of cystic fibrosis. Learn More
  28. Glyburide

    Catalog No. A10433
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    K+ channel and CFTR Cl- channel blocker
  29. IOWH032

    Catalog No. A13511
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    CFTR inhibitor
    IOWH032 is a CFTR inhibitor. Learn More
  30. CFTR-Inhibitor-II

    Catalog No. A13723
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    CFTR inhibitor
    CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 uM). Learn More
  31. PPQ-102

    Catalog No. A13000
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    CFTR chloride channel inhibitor
    PPQ-102 is a compound that targets intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR- mediated chloride current in a voltage-dependent and reversible manner. Learn More
  32. Oridonin (Isodonol)

    Catalog No. A10675
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    CFTR Inhibitor
    Oridonin (Isodonol), an entkaurane diterpenoid isolated from Rabdosia rubescens, is an important traditional Chinese herbal remedy. Learn More
  33. CFTRinh-172

    Catalog No. A12897
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    CFTR inhibitor
    CFTRinh-172 is a voltage-independent, selective CFTR inhibitor Learn More
  34. KM 11060

    Catalog No. A15843
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    F508del-CFTR trafficking corrector
    KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity Learn More
  35. PG 01

    Catalog No. A18315
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    CFTR potentiator
    PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. PG 01 is effective on G970R although with a significant decrease in potency relative to E193K and δF508. Learn More
  36. CFTR corrector 2

    Catalog No. A18528
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    CFTR corrector
    CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933. Learn More
  37. GLPG2451

    Catalog No. A18919
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    CFTR potentiator
    GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM. Learn More
  38. Ivacaftor benzenesulfonate

    Catalog No. A15132
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    CFTR potentiator
    Ivacaftor benzenesulfonate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment. Learn More
  39. Ivacaftor hydrate

    Catalog No. A15133
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    CFTR potentiator
    Ivacaftor hydrate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment. Learn More
  40. Caldaret

    Catalog No. A13148
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    intracellular Ca2+ handling modulator
    Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition. Learn More
  41. ABT-639 hydrochloride

    Catalog No. A12571
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    T-type Ca2+ channel blocker
    ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker. Learn More
  42. (S)-(-)-Bay-K-8644

    Catalog No. A21164
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    L-type Ca2+ channel agonist
    (S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM). Learn More
  43. TTA-Q6

    Catalog No. A21360
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    T-type Ca2+ channel antagonist
    TTA-Q6 is a selective T-type Ca2+ channel antagonist, used in the neurological disease. Learn More
  44. TTA-Q6(isomer)

    Catalog No. A21724
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    T-type Ca2+ channel antagonist
    TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca2+ channel antagonist. Learn More
  45. JTV-519 free base

    Catalog No. A21846
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    Ca2+-dependent blocker
    TV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties. Learn More
  46. GV-58

    Catalog No. A21966
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    N- and P/Q-type Ca2+ channels agonist
    GV-58 is a potent, selective N- and P/Q-type Ca2+ channels agonist with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel; 20-fold less potent CDK inhibitor activity. Learn More
  47. Tetrandrine (Fanchinine)

    Catalog No. A10921
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    Calcium Channel inhibitor
    Tetrandrine is a calcium channel blocker. It inhibits the degranulation of mast cells.Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis. Learn More
  48. Astragaloside A

    Catalog No. A11405
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    Ca2+ signaling modulator
    Astragaloside A is a novel regulator of HIF-1α and angiogenesis through the PI3K/Akt pathway in HUVECs that are exposed to hypoxia. Learn More
  49. CK-1827452 (Omecamtiv mecarbil)

    Catalog No. A11206
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    Myosin activator
    CK-1827452 is a selective cardiac specific myosin activator. Learn More
  50. Manidipine 2HCl

    Catalog No. A10554
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    Manidipine 2HCl is a HCl salt form of Manidipine which is a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. Learn More

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