CEP-32496

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Catalog No. A13772

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CEP-32496 5mg A13772-5

Regular Price: $150.00

Special Price: $127.50

CEP-32496 10mg A13772-10

Regular Price: $250.00

Special Price: $212.50

CEP-32496 25mg A13772-25

Regular Price: $490.00

Special Price: $416.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity.

CEP-32496

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Chemical Information

Catalog Num A13772
Actions No
M. Wt 553.92
Formula C24H23ClF3N5O5
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1188910-76-0
Synonyms CEP32496, CEP 32496, AC013773, AC 013773, AC-013773
SMILES code CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F
Chemical Name 1-(3-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride.

Biological Activity

Description
CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity.
Targets
Target Value
c-KitKd2nM
LCKKd2nM
PDGFRβKd2nM
RETKd2nM
Abl1Kd3nM
VEGFR2Kd8nM
CSF-1RKd9nM
B-Raf(V600E)Kd14nM
EphA2Kd14nM
EGFRKd22nM
B-RafKd36nM
C-RafKd39nM
c-MetKd513nM
JAK2Kd4.7μM
MEK1Kd7.1μM
MEK2Kd8.3μM
JAK1Kd>10μM
JAK3Kd>10μM
ALKKd>10μM
AuroraAKd>10μM
AuroraBKd>10μM
ERK1Kd>10μM
ERK2Kd>10μM
IGF-1RKd>10μM
INSRKd>10μM
PIK3-CAKd>10μM
PIK3-CBKd>10μM
PLK1Kd>10μM

Solubility

Solubility (25°C) * In vitro DMSO 9 mg/mL (17.39 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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