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MAPK

Items 1-50 of 239

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Product Name
Application
Product Information
Product Citation
  1. A10001
    Sorafenib Tosylate (Nexavar)

    Raf inhibitor

    Sorafenib Tosylate (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
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  2. A10002
    PLX-4720

    Raf inhibitor

    PLX-4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf.
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  3. A10089
    AS703026 (Pimasertib)

    MEK1/2 inhibitor

    AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.
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  4. A10092
    Asiatic acid

    Anti-inflammatory agent

    Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid derivative synthesis can be used as Anticancer agents; Glycogen phosphorylase inhibitors; Hepatoprotectants.

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  5. A10115
    AZD8330

    MEK Inhibitor

    AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
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  6. A10148
    Doramapimod (BIRB-796)

    p38 MAPK inhibitor

    Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
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  7. A10150
    BIX02188

    MEK5 inhibitor

    BIX02188 is a potent and selective inhibitor of MEK5.
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  8. A10151
    (E/Z)-BIX 02189

    MEK inhibitor

    BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
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  9. A10212
    PD184352 (CI-1040)

    MEK1/2 inhibitor

    PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
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  10. A10250
    Regorafenib (BAY 73-4506)

    VEGFR inhibitor

    Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature.
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  11. A10256
    PD0325901

    MEK inhibitor

    PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
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  12. A10257
    AZD6244 (Selumetinib)

    MEK inhibitor

    AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
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  13. A10420
    GDC-0879

    B-Raf inhibitor

    GDC-0879 is a specific inhibitor of B-Raf kinase enzyme,targeting B-Raf (V600E) (IC50: 0.13 nM).
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  14. A10453
    Honokiol

    Antiangiogenic and Antitumor Agent

    Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines.
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  15. A10545
    LY2228820 (Ralimetinib)

    p38 MAPK inhibitor

    LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.
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  16. A10661
    NVP-BHG712

    EphB4 inhibitor

    NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
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  17. A10704
    PD318088

    MEK Inhibitor

    PD318088 is an inhibitor of MEK1 AND MEK2.
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  18. A10705
    PD98059

    MEK Inhibitor

    PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.
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  19. A10739
    PLX4032 (Vemurafenib)

    Raf inhibitor

    PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.
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  20. A10773
    RAF265 (CHIR-265)

    RAF/VEGFR Inhibitor

    RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.
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  21. A10774
    Raf265 derivative

    RAF/VEGFR Inhibitor

    Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM.
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  22. A10823
    SB 202190

    p38 MAPK Inhibitor

    SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase.
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  23. A10824
    SB 203580

    p38 MAPK inhibitor

    SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
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  24. A10829
    SB590885

    B-Raf Inhibitor

    SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.
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  25. A10860
    SP600125

    JNK inhibitor

    SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3.
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  26. A10895
    Pexmetinib (ARRY-614)

    p38 MAPK inhibitor

    Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.
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  27. A10957
    U0126-EtOH

    MEK inhibitor

    U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
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  28. A10970
    AMG 548

    p38 MAPK inhibitor

    AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.
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  29. A10982
    VX-702

    p38 MAPK inhibitor

    VX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM).
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  30. A10983
    Neflamapimod (VX-745)

    p38 MAPK inhibitor

    VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .
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  31. A11029
    GSK1120212 (JTP-74057, Trametinib)

    MEK Inhibitor

    GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
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  32. A11040
    TAK-733

    MEK Inhibitor

    TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.
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  33. A11063
    AZ628

    Raf inhibitor

    AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.
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  34. A11077
    ZM 336372

    C-Raf inhibitor

    ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells.
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  35. A11078
    PH-797804

    p38 MAPK inhibitor

    PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.
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  36. A11101
    SKF 86002 Dihydrochloride

    p38 MAPK inhibitor

    SKF 86002 Dihydrochloride is inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 uM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 uM).
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  37. A11211
    ML 786 dihydrochloride

    Raf inhibitor

    ML 786 dihydrochloride is a potent Raf kinase inhibitor (IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively).
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  38. A11221
    PD 169316

    p38 MAPK inhibitor

    PD 169316 (PD169316) is a selective inhibitor of p38 MAPK.1 that inhibits p38 MAPK with an IC50 of 89 nM.
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  39. A11225
    Pluripotin (SC-1)

    ERK1/RasGAP Inhibitor

    The activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.
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  40. A11240
    MLN2480 (BIIB-024)

    pan-Raf inhibitor

    MLN 2480 is an oral, selective pan-Raf kinase inhibitor in chinical trials.
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  41. A11247
    RO4927350

    MEK1/2 inhibitor

    RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor.
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  42. A11264
    Refametinib

    MEK inhibitor

    Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
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  43. A11271
    Anisomycin

    SAPKs/JNKs activator

    Anisomycin is a pyrrolidine antibiotic, acts as an anti-fungal antibiotic which inhibits Protein Synthesis, also is a potent activator of SAPKs/JNKs.
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  44. A11281
    AEG 3482

    JNK inhibitor

    AEG 3482 is a small-molecule inhibitor of Jun kinase (JNK)-dependent apoptosis.
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  45. A11282
    PF-3644022

    MK2 Inhibitor

    PF-3644022 is a potent and selective mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) inhibitor (Ki =3 nM).
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  46. A11296
    AS 602801 (Bentamapimod)

    JNK inhibitor

    AS 602801 is a novel, orally active, Jun Kinase Inhibitor.
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  47. A11321
    Skepinone-L

    p38 MAPK inhibitor

    Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
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  48. A11333
    BRAF inhibitor

    BRAF inhibitor

    BRAF inhibitor is a potent BRAF inhibitor.
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  49. A11352
    CC-401

    JNK inhibitor

    CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
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  50. A11381
    Dabrafenib (GSK2118436A)

    Raf inhibitor

    Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
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