MAPK

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  1. Honokiol

    Catalog No. A10453
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    Antiangiogenic and Antitumor Agent
    Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Learn More
  2. SL-327

    Catalog No. A14137
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    MKK/MEK inhibitor
    SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration. Learn More
  3. Refametinib

    Catalog No. A11264
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    MEK inhibitor
    Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. Learn More
  4. Cobimetinib (racemate)

    Catalog No. A15050
    MEK inhibitor
    Cobimetinib is a potent, highly selective inhibitor of MEK1/2. Learn More
  5. Cobimetinib (R-enantiomer)

    Catalog No. A15051
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    MEK inhibitor
    Cobimetinib R-enantiomer is the R-enantiomer of Cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2). Learn More
  6. MEK inhibitor

    Catalog No. A15157
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    MEK inhibitor
    MEK inhibitor is a potent MEK inhibitor, antitumor agent. Learn More
  7. BI-847325

    Catalog No. A15762
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    MEK/Aurora Inhibitor
    BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. Learn More
  8. G-479

    Catalog No. A14380
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    MEK inhibitor
    G-479 is an potent MEK inhibitor. G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects. Learn More
  9. GDC-0623

    Catalog No. A12974
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    MEK1 inhibitor
    GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. Learn More
  10. PD 198306

    Catalog No. A16032
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    MEK inhibitor
    PD 198306 is a potent, selective and non-ATP competitive MAPK/ERK-kinase (MEK) inhibitor. Learn More
  11. PD 334581

    Catalog No. A16044
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    MEK1 inhibitor
    PD 334581 is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. It is also an inhibitor of MEK1. Learn More
  12. GW284543

    Catalog No. A18808
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    MEK5 inhibitor
    GW284543, also known as UNC10225170;, is a potent and selective MEK5 inhibitor with the potential for cancer treatment. Learn More
  13. EBI-1051

    Catalog No. A13176
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    MEK inhibitor
    EBI-1051 is a highly potent and orally efficacious MEK inhibitor with an IC50 of 3.9 nM. Learn More
  14. Cobimetinib hemifumarate

    Catalog No. A18033
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    MEK1 inhibitor
    Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM. Learn More
  15. Trametinib (DMSO solvate)

    Catalog No. A21450
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    MEK inhibitor
    Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM. Learn More
  16. BIX02189

    Catalog No. A21729
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    MEK5 inhibitor
    BIX02189 is a potent and selective MEK5 inhibitor with an IC50 of 1.5 nM. BIX02189 also inhibits ERK5 catalytic activity with an IC50 of 59 nM. Learn More
  17. PD0325901

    Catalog No. A10256
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    MEK inhibitor
    PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2. Learn More
  18. AZD6244 (Selumetinib)

    Catalog No. A10257
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    MEK inhibitor
    AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm. Learn More
  19. PD98059

    Catalog No. A10705
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    MEK Inhibitor
    PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. Learn More
  20. PD184352 (CI-1040)

    Catalog No. A10212
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    MEK1/2 inhibitor
    PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2. Learn More
  21. U0126-EtOH

    Catalog No. A10957
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    MEK inhibitor
    U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively. Learn More
  22. AS703026 (Pimasertib)

    Catalog No. A10089
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    MEK1/2 inhibitor
    AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation. Learn More
  23. GSK1120212 (JTP-74057, Trametinib)

    Catalog No. A11029
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    MEK Inhibitor
    GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases. Learn More
  24. BIX 02189

    Catalog No. A10151
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    MEK inhibitor
    BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively. Learn More
  25. TAK-733

    Catalog No. A11040
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    MEK Inhibitor
    TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Learn More
  26. AZD8330

    Catalog No. A10115
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    MEK Inhibitor
    AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. Learn More
  27. PD318088

    Catalog No. A10704
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    MEK Inhibitor
    PD318088 is an inhibitor of MEK1 AND MEK2. Learn More
  28. BIX02188

    Catalog No. A10150
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    MEK5 inhibitor
    BIX02188 is a potent and selective inhibitor of MEK5. Learn More
  29. GDC-0973 (Cobimetinib)

    Catalog No. A11441
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    MEK1 inhibitor
    Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Learn More
  30. MEK162 (ARRY-438162, Binimetinib)

    Catalog No. A11493
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    MEK1/2 inhibitor
    MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2. Learn More
  31. RO4927350

    Catalog No. A11247
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    MEK1/2 inhibitor
    RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. Learn More
  32. Refametinib (RDEA-119, BAY 86-9766)

    Catalog No. A12866
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    MEK1/2 inhibitor
    Refametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity. Learn More
  33. Balamapimod (MKI-833)

    Catalog No. A13119
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    Ras/Raf/MEK inhibitor
    Balamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor. Learn More
  34. RO5126766 (CH5126766)

    Catalog No. A14019
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    Raf/MEK dual inhibitor
    RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Learn More
  35. Hypothemycin

    Catalog No. A13750
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    Hypothemycin is a resorcylic acid lactone polyketide. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 mAb alone. Learn More
  36. RO4987655

    Catalog No. A13272
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    MEK1 inhibitor
    RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Learn More
  37. ERK5-IN-2

    Catalog No. A18871
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    ERK5 inhibitor
    ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. Learn More
  38. BAY885

    Catalog No. A13765
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    ERK5 inhibitor
    BAY885 is a novel ERK5 inhibitor. Learn More
  39. Pluripotin (SC-1)

    Catalog No. A11225
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    ERK1/RasGAP Inhibitor
    The activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively. Learn More
  40. Ulixertinib (BVD-523, VRT752271)

    Catalog No. A11794
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    ERK1/ERK2 inhibitor
    VRT752271 is a pyrrole inhibitors of ERK protein kinase. Learn More
  41. SCH772984

    Catalog No. A12824
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    ERK Inhibitor
    SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. Learn More
  42. TCS ERK 11e (VX-11e)

    Catalog No. A12505
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    ERK2 inhibitor
    TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Learn More
  43. GDC0994 (Ravoxertinib)

    Catalog No. A13420
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    ERK1/2 inhibitor
    GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. Learn More
  44. XMD 17-109

    Catalog No. A14090
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    ERK5 inhibitor
    XMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 uM in HEK293 cells. Learn More
  45. FR 180204

    Catalog No. A14119
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    ERK inhibitor
    FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis. Learn More
  46. XMD8-92

    Catalog No. A11609
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    BMK1/ERK5 inhibitor
    XMD8-92 is a potent and selective BMK1/ERK5 inhibitor . Learn More
  47. TMCB

    Catalog No. A13977
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    CK2/ERK8 inhibitor
    MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8). Learn More
  48. DEL-22379

    Catalog No. A15802
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    ERK inhibitor
    DEL-22379 is a potent and selective ERK Dimerization inhibitor that inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes. Learn More
  49. APS-2-79

    Catalog No. A16231
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    KSR/Ras inhibitor
    APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site. Learn More
  50. ERK5-IN-1

    Catalog No. A16232
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    ERK5 inhibitor
    ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 uM and enzymatic IC50 values of 0.087 uM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026uM. Learn More

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