MAPK

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  1. Honokiol

    Catalog No. A10453
    Antiangiogenic and Antitumor Agent
    Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Learn More
  2. SL-327

    Catalog No. A14137
    MKK/MEK inhibitor
    SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration. Learn More
  3. Refametinib

    Catalog No. A11264
    MEK inhibitor
    Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. Learn More
  4. Cobimetinib (racemate)

    Catalog No. A15050
    MEK inhibitor
    Cobimetinib is a potent, highly selective inhibitor of MEK1/2. Learn More
  5. Cobimetinib (R-enantiomer)

    Catalog No. A15051
    MEK inhibitor
    Cobimetinib R-enantiomer is the R-enantiomer of Cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2). Learn More
  6. MEK inhibitor

    Catalog No. A15157
    MEK inhibitor
    MEK inhibitor is a potent MEK inhibitor, antitumor agent. Learn More
  7. BI-847325

    Catalog No. A15762
    MEK/Aurora Inhibitor
    BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. Learn More
  8. G-479

    Catalog No. A14380
    MEK inhibitor
    G-479 is an potent MEK inhibitor. G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects. Learn More
  9. GDC-0623

    Catalog No. A12974
    MEK1 inhibitor
    GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. Learn More
  10. PD 198306

    Catalog No. A16032
    MEK inhibitor
    PD 198306 is a potent, selective and non-ATP competitive MAPK/ERK-kinase (MEK) inhibitor. Learn More
  11. PD 334581

    Catalog No. A16044
    MEK1 inhibitor
    PD 334581 is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. It is also an inhibitor of MEK1. Learn More
  12. PD0325901

    Catalog No. A10256
    MEK inhibitor
    PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2. Learn More
  13. AZD6244 (Selumetinib)

    Catalog No. A10257
    MEK inhibitor
    AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm. Learn More
  14. PD98059

    Catalog No. A10705
    MEK Inhibitor
    PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. Learn More
  15. PD184352 (CI-1040)

    Catalog No. A10212
    MEK1/2 inhibitor
    PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2. Learn More
  16. U0126-EtOH

    Catalog No. A10957
    MEK inhibitor
    U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively. Learn More
  17. AS703026 (Pimasertib)

    Catalog No. A10089
    MEK1/2 inhibitor
    AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation. Learn More
  18. MEK Inhibitor
    GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases. Learn More
  19. BIX 02189

    Catalog No. A10151
    MEK inhibitor
    BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively. Learn More
  20. TAK-733

    Catalog No. A11040
    MEK Inhibitor
    TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Learn More
  21. AZD8330

    Catalog No. A10115
    MEK Inhibitor
    AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. Learn More
  22. PD318088

    Catalog No. A10704
    MEK Inhibitor
    PD318088 is an inhibitor of MEK1 AND MEK2. Learn More
  23. BIX02188

    Catalog No. A10150
    MEK5 inhibitor
    BIX02188 is a potent and selective inhibitor of MEK5. Learn More
  24. GDC-0973 (Cobimetinib)

    Catalog No. A11441
    MEK1 inhibitor
    Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Learn More
  25. MEK1/2 inhibitor
    MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2. Learn More
  26. RO4927350

    Catalog No. A11247
    MEK1/2 inhibitor
    RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. Learn More
  27. MEK1/2 inhibitor
    Refametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity. Learn More
  28. Balamapimod (MKI-833)

    Catalog No. A13119
    Ras/Raf/MEK inhibitor
    Balamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor. Learn More
  29. RO5126766 (CH5126766)

    Catalog No. A14019
    Raf/MEK dual inhibitor
    RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Learn More
  30. Hypothemycin

    Catalog No. A13750
    Hypothemycin is a resorcylic acid lactone polyketide. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 mAb alone. Learn More
  31. RO4987655

    Catalog No. A13272
    MEK1 inhibitor
    RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Learn More
  32. Pluripotin (SC-1)

    Catalog No. A11225
    ERK1/RasGAP Inhibitor
    The activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively. Learn More
  33. ERK1/ERK2 inhibitor
    VRT752271 is a pyrrole inhibitors of ERK protein kinase. Learn More
  34. SCH772984

    Catalog No. A12824
    ERK Inhibitor
    SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. Learn More
  35. TCS ERK 11e (VX-11e)

    Catalog No. A12505
    ERK2 inhibitor
    TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Learn More
  36. GDC0994

    Catalog No. A13420
    ERK1/2 inhibitor
    GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. Learn More
  37. XMD 17-109

    Catalog No. A14090
    ERK5 inhibitor
    XMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 uM in HEK293 cells. Learn More
  38. FR 180204

    Catalog No. A14119
    ERK inhibitor
    FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis. Learn More
  39. XMD8-92

    Catalog No. A11609
    BMK1/ERK5 inhibitor
    XMD8-92 is a potent and selective BMK1/ERK5 inhibitor . Learn More
  40. TMCB

    Catalog No. A13977
    CK2/ERK8 inhibitor
    MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8). Learn More
  41. DEL-22379

    Catalog No. A15802
    ERK inhibitor
    DEL-22379 is a potent and selective ERK Dimerization inhibitor that inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes. Learn More
  42. APS-2-79

    Catalog No. A16231
    KSR/Ras inhibitor
    APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site. Learn More
  43. ERK5-IN-1

    Catalog No. A16232
    ERK5 inhibitor
    ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 uM and enzymatic IC50 values of 0.087 uM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026uM. Learn More
  44. Tomatidine

    Catalog No. A16233
    ERK/Akt/NF-kB inhibitor
    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties. Learn More
  45. CC-90003

    Catalog No. A16837
    ERK1/2 inhibitor
    CC-90003 is an irreversible inhibitor of ERK1/2 with IC50s in the 10-20 nM range and shows good kinase selectivity in a 258-kinase biochemical assay. Learn More
  46. MK-8353 (SCH900353)

    Catalog No. A16838
    ERK inhibitor
    MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay). Learn More
  47. AZD0364

    Catalog No. A16839
    ERK inhibitor
    AZD0364 is a pre-clinical ERK1/2 inhibitor with an IC50 of 0.6 nM for ERK2. Learn More
  48. LY3214996

    Catalog No. A16843
    ERK inhibitor
    LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines. Learn More
    • New

    AG-126

    Catalog No. A17146
    ERK2 inhibitor
    AG-126 is a ERK2 inhibitor that selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. Learn More
  49. SB-242235

    Catalog No. A13678
    p38 MAPK inhibitor
    SB-242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases. Learn More

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