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GSK1120212 (JTP-74057, Trametinib)
Catalog No. A11029 MEK InhibitorGSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases. Learn More -
PD98059
Catalog No. A10705 MEK InhibitorPD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. Learn More -
AZD6244 (Selumetinib)
Catalog No. A10257 MEK inhibitorAZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm. Learn More -
MEK162 (ARRY-438162, Binimetinib)
Catalog No. A11493 MEK1/2 inhibitorMEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2. Learn More -
U0126-EtOH
Catalog No. A10957 MEK inhibitorU0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively. Learn More -
PD0325901
Catalog No. A10256 MEK inhibitorPD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2. Learn More -
BIX 02189
Catalog No. A10151 MEK inhibitorBIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively. Learn More -
GDC-0973 (Cobimetinib)
Catalog No. A11441 MEK1 inhibitorCobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Learn More -
Refametinib (RDEA-119, BAY 86-9766)
Catalog No. A12866 MEK1/2 inhibitorRefametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity. Learn More -
Cobimetinib (racemate)
Catalog No. A15050 MEK inhibitorCobimetinib is a potent, highly selective inhibitor of MEK1/2. Learn More -
BI-847325
Catalog No. A15762 MEK/Aurora InhibitorBI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. Learn More -
Honokiol
Catalog No. A10453 Antiangiogenic and Antitumor AgentHonokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Learn More -
SL-327
Catalog No. A14137 MKK/MEK inhibitorSL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration. Learn More -
Refametinib
Catalog No. A11264 MEK inhibitorRefametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. Learn More -
Cobimetinib (R-enantiomer)
Catalog No. A15051 MEK inhibitorCobimetinib R-enantiomer is the R-enantiomer of Cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2). Learn More -
MEK inhibitor
Catalog No. A15157 -
G-479
Catalog No. A14380 MEK inhibitorG-479 is an potent MEK inhibitor. G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects. Learn More -
GDC-0623
Catalog No. A12974 MEK1 inhibitorGDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. Learn More -
PD 198306
Catalog No. A16032 MEK inhibitorPD 198306 is a potent, selective and non-ATP competitive MAPK/ERK-kinase (MEK) inhibitor. Learn More -
PD 334581
Catalog No. A16044 MEK1 inhibitorPD 334581 is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. It is also an inhibitor of MEK1. Learn More -
EPZ031686
Catalog No. A16375 SMYD3/ MEKK2 inhibitorEPZ031686 is a noncompetitive inhibitor for SMYD3 and MEKK2 with a Ki=1.2 and 1.1 nM respectively. Learn More -
GW284543
Catalog No. A18808 MEK5 inhibitorGW284543, also known as UNC10225170;, is a potent and selective MEK5 inhibitor with the potential for cancer treatment. Learn More -
EBI-1051
Catalog No. A13176 MEK inhibitorEBI-1051 is a highly potent and orally efficacious MEK inhibitor with an IC50 of 3.9 nM. Learn More -
Cobimetinib hemifumarate
Catalog No. A18033 MEK1 inhibitorCobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM. Learn More -
Trametinib (DMSO solvate)
Catalog No. A21450 MEK inhibitorTrametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM. Learn More -
BIX02189
Catalog No. A21729 MEK5 inhibitorBIX02189 is a potent and selective MEK5 inhibitor with an IC50 of 1.5 nM. BIX02189 also inhibits ERK5 catalytic activity with an IC50 of 59 nM. Learn More -
PD184161
Catalog No. A22601 -
PD184352 (CI-1040)
Catalog No. A10212 MEK1/2 inhibitorPD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2. Learn More -
AS703026 (Pimasertib)
Catalog No. A10089 MEK1/2 inhibitorAS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation. Learn More -
TAK-733
Catalog No. A11040 MEK InhibitorTAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Learn More -
AZD8330
Catalog No. A10115 MEK InhibitorAZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. Learn More -
PD318088
Catalog No. A10704 -
BIX02188
Catalog No. A10150 -
RO4927350
Catalog No. A11247 MEK1/2 inhibitorRO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. Learn More -
Balamapimod (MKI-833)
Catalog No. A13119 Ras/Raf/MEK inhibitorBalamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor. Learn More -
RO5126766 (CH5126766)
Catalog No. A14019 Raf/MEK dual inhibitorRO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Learn More -
Hypothemycin
Catalog No. A13750 Hypothemycin is a resorcylic acid lactone polyketide. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 mAb alone. Learn More -
RO4987655
Catalog No. A13272 MEK1 inhibitorRO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Learn More -
SCH772984
Catalog No. A12824 ERK InhibitorSCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. Learn More -
FR 180204
Catalog No. A14119 ERK inhibitorFR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis. Learn More -
TCS ERK 11e (VX-11e)
Catalog No. A12505 ERK2 inhibitorTCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Learn More -
ERK5-IN-2
Catalog No. A18871 ERK5 inhibitorERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. Learn More -
Pluripotin (SC-1)
Catalog No. A11225 ERK1/RasGAP InhibitorThe activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively. Learn More -
Ulixertinib (BVD-523, VRT752271)
Catalog No. A11794 ERK1/ERK2 inhibitorVRT752271 is a pyrrole inhibitors of ERK protein kinase. Learn More -
GDC0994 (Ravoxertinib)
Catalog No. A13420 ERK1/2 inhibitorGDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. Learn More -
XMD 17-109
Catalog No. A14090 ERK5 inhibitorXMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 uM in HEK293 cells. Learn More -
XMD8-92
Catalog No. A11609 BMK1/ERK5 inhibitorXMD8-92 is a potent and selective BMK1/ERK5 inhibitor . Learn More -
TMCB
Catalog No. A13977 CK2/ERK8 inhibitorMCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8). Learn More -
DEL-22379
Catalog No. A15802 ERK inhibitorDEL-22379 is a potent and selective ERK Dimerization inhibitor that inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes. Learn More
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