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Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

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Topoisomerase inhibitor

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Catalog No. A10194

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Cerubidine 10mg A10194-10
$60.00
Cerubidine 25mg A10194-25
$100.00
Cerubidine 50mg A10194-50
$160.00
Cerubidine 100mg A10194-100
$260.00
Cerubidine 10mM * 1mL in DMSO A10194-10mM-D
$93.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

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Chemical Information

Catalog Num A10194
Actions Inhibitor
M. Wt 564.0
Formula C27H29NO10.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 23541-50-6
Synonyms Daunorubicin HCl, Rubidomycin HCl
SMILES code C[[email protected]]1[[email protected]]([[email protected]](C[[email protected]@H](O1)O[[email protected]]2C[[email protected]@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
Chemical Name (8S,10S)-8-acetyl-10-[(2S,4S,5S,6S)- 4-amino-5-hydroxy-6-methyl-oxan- 2-yl]oxy-6,8,11-trihydroxy-1-methoxy- 9,10-dihydro-7H-tetracene-5,12-dione hydrochloride

Biological Activity

Description

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

Targets
DNA synthesis (Cell-free assay)
20 nM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 113 mg/mL (200.36 mM)
Water 113 mg/mL (200.36 mM)
Ethanol 13 mg/mL (23.05 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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