DNA Damage

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  1. Romidepsin (FK228 ,Depsipeptide)

    Catalog No. A11920
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    HDAC inhibitor
    Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively. Learn More
  2. LBH589 (Panobinostat)

    Catalog No. A10518
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    HDAC Inhibitor
    LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM. Learn More
  3. Trichostatin-A (TSA)

    Catalog No. A10947
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    HDAC Inhibitor
    Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM. Learn More
  4. MC1568

    Catalog No. A10560
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    HDAC Inhibitor
    MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis. Learn More
  5. Vorinostat (SAHA)

    Catalog No. A10979
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    HDAC inhibitor
    Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Learn More
  6. JNJ-26481585 (Quisinostat)

    Catalog No. A10492
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    HDAC inhibitor
    JNJ-26481585 (Quisinostat) is a pan-HDAC inhibitor with marked potency toward HDAC1 (IC(50), 0.16 nmol/L). Learn More
  7. MS-275 (Entinostat)

    Catalog No. A10611
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    HDAC inhibitor
    MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively. Learn More
  8. Belinostat (PXD101)

    Catalog No. A10122
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    HDAC inhibitor
    Belinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. Learn More
  9. MGCD0103 (Mocetinostat)

    Catalog No. A10586
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    HDAC Inhibitor
    MGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11. Learn More
  10. AR-42 (HDAC-42)

    Catalog No. A11037
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    HDAC inhibitor
    AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit. Learn More
  11. SB939 ( Pracinostat )

    Catalog No. A10830
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    HDAC inhibitor
    SB939 is an oral inhibitor of HDAC, selective for class I, II and IV HDACs and displays an IC50 value of 77 nM in an in vitro HDAC1 activity assay. Learn More
  12. CUDC-907 (Fimepinostat)

    Catalog No. A11153
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    PI3K/HDAC inhibitor
    CUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses. Learn More
  13. R306465

    Catalog No. A15437
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    HDAC inhibitor
    R306465 is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. Learn More
  14. Citarinostat (ACY-241)

    Catalog No. A12758
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    HDAC6 inhibitor
    ACY-241 is a new, selective and orally available inhibitor of HDAC6. Learn More
  15. ACY-738

    Catalog No. A15934
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    HDAC6 inhibitor
    ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. Learn More
  16. TMP 269

    Catalog No. A14128
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    HDAC inhibitor
    TMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Learn More
  17. RG2833 (RGFP109)

    Catalog No. A13139
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    HDAC inhibitor
    RG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3. Learn More
  18. Resminostat hydrochloride

    Catalog No. A15220
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    HDAC inhibitor
    Resminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM. Learn More
  19. KD 5170

    Catalog No. A15354
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    HDAC inhibitor
    KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. Learn More
  20. NCH 51

    Catalog No. A15355
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    HDAC Inhibitor
    NCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM. Learn More
  21. NSC 3852

    Catalog No. A15356
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    HDAC Inhibitor
    NSC 3852 is an HDAC (histone deacetylase) inhibitor. Learn More
  22. TC-H 106

    Catalog No. A15357
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    HDAC inhibitor
    TC-H 106 is a slow, tight-binding inhibitor of class I HDACs (histone deacetylases). Learn More
  23. TCS HDAC6 20b

    Catalog No. A15387
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    HDAC6 inhibitor
    TCS HDAC6 20b, selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol. Also inhibits growth of MCF-7 cells stimulated by estrogen. Learn More
  24. BML-210

    Catalog No. A15935
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    HDAC inhibitor‎
    BML-210 is HDAC inhibitor. BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. Learn More
  25. M344

    Catalog No. A11355
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    HDAC inhibitor
    M344 is a potent inhibitor of HDAC with IC50 of 100 nM and able to induce cell differentiation. Learn More
  26. BG45

    Catalog No. A11361
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    HDAC inhibitor
    BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively). Learn More
  27. ITSA-1

    Catalog No. A16127
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    HDAC inhibitor
    ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. Learn More
  28. CRA-026440

    Catalog No. A12179
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    HDAC inhibitor
    CRA-026440 is a potent, broad-spectrum HDAC inhibitor. Learn More
  29. Valproic acid sodium salt

    Catalog No. A10855
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    HDAC inhibitor
    Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Learn More
  30. JAK/HDAC-IN-1

    Catalog No. A13362
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    JAK2/HDAC dual inhibitor
    JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. Learn More
  31. Sodium phenylbutyrate

    Catalog No. A16714
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    HDAC/ER stress inhibitor
    Sodium phenylbutyrate is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Learn More
  32. Tubastatin A

    Catalog No. A16770
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    HDAC6 inhibitor
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Learn More
  33. CG-200745

    Catalog No. A20939
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    HDAC inhibitor
    CG-200745 is a potent HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Learn More
  34. Givinostat

    Catalog No. A21126
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    HDAC inhibitor
    Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Learn More
  35. HDAC-IN-7

    Catalog No. A21252
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    HDAC1/2/3/10 inhibitor
    HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor. Learn More
  36. Givinostat hydrochloride

    Catalog No. A21487
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    HDAC inhibitor
    Givinostat hydrochloride (ITF-2357 hydrochloride) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Learn More
  37. Nanatinostat

    Catalog No. A21625
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    HDAC inhibitor
    Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM. Learn More
  38. Belinostat

    Catalog No. A21772
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    HDAC inhibitor
    Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts. Learn More
  39. HDAC-IN-5

    Catalog No. A20972
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    HDAC inhibitor
    HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor. Learn More
  40. Domatinostat tosylate

    Catalog No. A20986
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    HDAC1 inhibitor
    Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Learn More
  41. J22352

    Catalog No. A19174
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    HDAC6 inhibitor
    J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM. Learn More
  42. BRD 4354

    Catalog No. A19532
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    HDAC5/HDAC9 inhibitor
    BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. Learn More
  43. FT895

    Catalog No. A19615
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    HDAC11 inhibitor
    FT895 is a potent and selective HDAC11 inhibitor with an IC50 of 3 nM. Learn More
  44. ACY-957

    Catalog No. A19666
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    HDAC1 /HDAC2 inhibitor
    ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. Learn More
  45. TH34

    Catalog No. A19873
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    HDAC6/8/10 inhibitor
    TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3. Learn More
  46. ACY-1083

    Catalog No. A19985
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    HDAC6 inhibitor
    ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. Learn More
  47. RTS-V5

    Catalog No. A20099
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    HDAC/proteasome inhibitor
    RTS-V5 is a dual HDAC/proteasome inhibitor with IC50s of 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively. Learn More
  48. Tefinostat

    Catalog No. A20258
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    pan HDAC inhibitor
    Tefinostat (CHR-2845) is a monocyte/macrophage-targeted pan HDAC inhibitor, cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Anti-monocytoid lineage leukaemias activity. Learn More
  49. Oxamflatin

    Catalog No. A20265
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    HDAC inhibitor
    Oxamflatin (Metacept-3) is a potent HDAC inhibitor with an IC50 of 15.7 nM. Learn More
  50. WT-161

    Catalog No. A20432
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    HDAC6 inhibitor
    WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM. Learn More

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