• Sign In
  • FAQ
  • Create an Account
Currency
USD currency flagUSD
Toggle Nav
My Cart
Menu
Account
Settings
Currency
USD currency flagUSD

DNA Damage

Items 1-50 of 3581

Page
per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Citations
  1. A10214
    Cidofovir (Vistide)

    DNA/RNA Synthesis inhibitor

    Cidofovir (Vistide) is an antiviral used for the treatment of cytomegalovirus (CMV) infection (ie: retinitis).
    Quick View
  2. A12011
    SN 38

    DNA topoisomerase Inhibitor

    SN 38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor).
    Quick View
  3. A10045
    Rucaparib (AG-014699) phosphate

    PARP inhibitor

    AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.
    Quick View
  4. A14199
    4EGI-1

    eIF4E/eIF4G inhibitor

    4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 uM.
    Quick View
  5. A10426
    Genistin (Genistoside)
    Genistin is an isoflavone found in a number of dietary plants like soy and kudzu. It was shown to stimulate estrogen-dependent breast cancer cell growth in vivo.
    Quick View
  6. A15064
    ABT 492 meglumine (Delafloxacin meglumine)
    ABT 492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms. in vitro:
    Quick View
  7. A12758
    Citarinostat (ACY-241)

    HDAC6 inhibitor

    ACY-241 is a new, selective and orally available inhibitor of HDAC6.
    Quick View
  8. A10373
    Etoposide (VP-16)

    Topoisomerase II inhibitor

    Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.
    Quick View
  9. A10388
    Fisetin (Fustel)
    Fisetin is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. Possible anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties of fisetin are under active scientific investigation.
    Quick View
  10. A16720
    STF-083010

    IRE1α inhibitor

    STF-083010 is a specific IRE1α inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.
    Quick View
  11. A11153
    CUDC-907 (Fimepinostat)

    PI3K/HDAC inhibitor

    CUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.
    Quick View
  12. A11098
    NU-7441 (KU-57788)

    DNA-PK inhibitor

    NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively.
    Quick View
  13. A12752
    NU7026

    DNA-PK inhibitor

    NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
    Quick View
  14. A16445
    Chloroquine Phosphate
    Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.
    Quick View
  15. A10560
    MC1568

    HDAC Inhibitor

    MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis.
    Quick View
  16. A10026
    ABT-888 (Veliparib)

    PARP inhibitor

    ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor.
    Quick View
  17. A10289
    Daptomycin

    DNA/RNA Synthesis inhibitor

    Daptomycin is a lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms.
    Quick View
  18. A14212
    Blasticidin S HCl
    Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor.
    Quick View
  19. A14403
    Doxorubicin

    Topoisomerase II inhibitor

    Doxorubicin is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
    Quick View
  20. A10611
    MS-275 (Entinostat)

    HDAC inhibitor

    MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively.
    Quick View
  21. A13780
    Ellipticine

    DNA topoisomerase II inhibitor

    Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor.
    Quick View
  22. A10423
    Gemcitabine HCl (Gemzar)

    DNA/RNA Synthesis inhibitor

    Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth.
    Quick View
  23. A11612
    YK 4-279

    RHA inhibitor

    YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1.
    Quick View
  24. A10152
    Bleomycin sulfate

    DNA/RNA Synthesis inhibitor

    Bleomycin sulfate is a mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus.
    Quick View
  25. A11920
    Romidepsin (FK228 ,Depsipeptide)

    HDAC inhibitor

    Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.
    Quick View
  26. A17323
    Valproic acid

    HDAC inhibitor

    Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
    Quick View
  27. A15934
    ACY-738

    HDAC6 inhibitor

    ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs.
    Quick View
  28. A10516
    LAQ824 (NVP-LAQ824, Dacinostat)

    HDAC Inhibitor

    LAQ824 (NVP-LAQ824) is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.
    Quick View
  29. A11586
    Torin 2

    mTOR inhibitor

    Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).
    Quick View
  30. A10726
    PI-103

    PI3K Inhibitor

    PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR.
    Quick View
  31. A15528
    G007-LK

    TNKS inhibitor

    G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice,
    Quick View
  32. A10862
    SRT1720 HCl

    SIRT1 Activator

    SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.
    Quick View
  33. A14188
    SRT2104 (GSK2245840)

    SIRT1 activator

    SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
    Quick View
  34. A10507
    KU-60019

    ATM Inhibitor

    KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM.
    Quick View
  35. A10947
    Trichostatin A (TSA)

    HDAC Inhibitor

    Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.
    Quick View
  36. A10994
    XAV 939

    PARP inhibitor

    XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively).
    Quick View
  37. A10488
    ITF2357 (Givinostat)

    HDAC inhibitor

    ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.
    Quick View
  38. A13328
    ETP-46464

    ATR inhibitor

    ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
    Quick View
  39. A13803
    4μ8C

    IRE1 Rnase inhibitor

    4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.
    Quick View
  40. A10830
    SB939 ( Pracinostat )

    HDAC inhibitor

    SB939 is an oral inhibitor of HDAC, selective for class I, II and IV HDACs and displays an IC50 value of 77 nM in an in vitro HDAC1 activity assay.
    Quick View
  41. A12676
    Salubrinal

    eIF2α dephosphorylation inhibitor

    Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).
    Quick View
  42. A11065
    CX-5461

    DNA/RNA Synthesis inhibitor

    CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively

    Quick View
  43. A15479
    VCH-759

    HCV Polymerase Inhibitor

    VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC50 values versus genotype 1a/1b replicons.
    Quick View
  44. A10140
    BIBR 1532

    Telomerase Inhibitor

    BIBR 1532 is a selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively).

    Quick View
  45. A12305
    Tenovin-6

    p53 activator

    Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.
    Quick View
  46. A16431
    CAY10603

    HDAC6 inhibitor

    CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs.
    Quick View
  47. A11042
    Tubastatin A HCl

    HDAC6 inhibitor

    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
    Quick View
  48. A10036
    Cycloheximide (Actidione)

    Protein Synthesis Inhibitor

    Cycloheximide (also known as actidione) is used as an selective antibiotic. It inhibits the protein synthesis (DNA-dependent RNA) of saprobic fungi eukaryotes. by binding with the 80S ribosome, while inactive against dermatophytes and systemic fungi.
    Quick View
  49. A10164
    BSI-201 (Iniparib)

    PARP1 inhibitor

    BSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier.
    Quick View
  50. A14182
    Rucaparib

    PARP-1 inhibitor

    Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells.
    Quick View

Items 1-50 of 3581

Page
per page
Set Descending Direction
Shop By
Shopping Options
Category
Actions
  1. Inhibitor 1503items
  2. Agonist 1item
  3. Activator 15items
  4. Modulator 2items
  5. Degrader 1item
  6. Inducer 1item
  7. Substrate 2items
Target
  1. HDAC 3items
  2. HDAC1 4items
  3. HDAC2 4items
  4. HDAC3 4items
  5. HDAC4 3items
  6. HDAC5 2items
  7. HDAC6 5items
  8. HDAC7 1item
  9. HDAC8 4items
  10. HDAC9 2items
  11. HDAC10 2items
  12. HDAC11 1item
  13. HD1 1item
  14. HD2 1item
  15. EGFR/ErbB1/HER1 1item
  16. ErbB2/HER2 1item
  17. GCN 2items
  18. PARP 8items
  19. PARP1 28items
  20. PARP2 22items
  21. PARP3 3items
  22. PARP4 1item
  23. TNKS1/PARP5A 11items
  24. TNKS2/PARP5B 11items
  25. PARP7 1item
  26. PARP10 1item
  27. PARP14 2items