CH5424802

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ALK Inhibitor

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Catalog No. A11134

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CH5424802 5mg A11134-5

Regular Price: $80.00

Special Price: $68.00

CH5424802 10mg A11134-10

Regular Price: $120.00

Special Price: $102.00

CH5424802 50mg A11134-50

Regular Price: $250.00

Special Price: $212.50

CH5424802 100mg A11134-100

Regular Price: $450.00

Special Price: $382.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CH5424802 is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK.

CH5424802

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Chemical Information

Catalog Num A11134
Actions Inhibitor
M. Wt 482.6
Formula C30H34N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1256580-46-7
Synonyms CH-5424802
SMILES code CCC1=C(C=C2C(=C1)C(=O)C3=C(C2(C)C)NC4=C3C=CC(=C4)C#N)N5CCC(CC5)N6CCOCC6
Chemical Name ETHYL-6,6-DIMETHYL-8-(4-MORPHOLINOPIPERIDIN-1-YL)-11-OXO-6,11-DIHYDRO-5H-BENZO[B]CARBAZOLE-3-CARBONITRILE

Biological Activity

Description
CH5424802 is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK.
Targets
Target Value
ALK(F1174L)IC50: 1nM
ALKIC50: 1.9nM
ALK(R1275Q)IC50: 3.5nM
INSRIC50: 550nM
KDRIC50: 1.4μM
AblIC50: >5μM
EGFRIC50: >5μM
FGFR2IC50: >5μM
HER2IC50: >5μM
IGF-1RIC50: >5μM
JAK1IC50: >5μM
KitIC50: >5μM
MetIC50: >5μM
PDGFRβIC50: >5μM
SrcIC50: >5μM
Akt1IC50: >5μM
Akt2IC50: >5μM
Akt3IC50: >5μM
AuroraAIC50: >5μM
CDK1IC50: >5μM
CDK2IC50: >5μM
MEK1IC50: >5μM
PKAIC50: >5μM
PKCαIC50: >5μM
PKCβ1IC50: >5μM
PKCβ2IC50: >5μM
Raf-1IC50: >5μM

Solubility

Solubility (25°C) * In vitro DMSO 2 mg/mL heating (4.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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