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Biological Activity
Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively.
| In vitro | DMSO | 2 mg/mL (3.85 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.26 mL | 96.32 mL | 192.65 mL |
| 0.5 mM | 3.85 mL | 19.26 mL | 38.53 mL |
| 1 mM | 1.93 mL | 9.63 mL | 19.26 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.85 mL |
*The above data is based on the productmolecular weight 519.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18000 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1256589-74-8 |
| Formula | C30H35ClN4O2 |
| M. Wt | 519.08 |
| Purity | >98% |
| Synonyms | CH5424802 Hydrochloride, CH 5424802, CH-5424802; RO5424802 Hydrochloride, RO 5424802, RO-5424802; AF-802 Hydrochloride, |
| SMILES | [H]Cl.N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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