Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD.
Adooq's Cilomilast (SB-207499) has been cited by 1 publications
Esraa M Mosalam, .et al. , Int J Mol Sci, 2025, Mar 28;26(7):3108 PMID: 40243772
Biological Activity
Description
Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD.
Targets
Target
Value
Product Information
Catalog Num
A10216
Formula
C20H25NO4
Molecular Weight
343.4
CAS Number
153259-65-5
SMILES
COC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3
Synonyms
Ariflo
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro (25°C)
DMSO
64 mg/mL (186.36 mM)
Water
Insoluble
Ethanol
47 mg/mL (136.85 mM)
In vivo
5% DMSO+95% Corn oil
28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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