CX-4945 (Silmitasertib)

CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.
Grouped product items
Product Name Price Stock Qty
CX-4945 (Silmitasertib) 2mg
$40.00
In stock
CX-4945 (Silmitasertib) 5mg
$80.00
In stock
CX-4945 (Silmitasertib) 10mg
$130.00
In stock
CX-4945 (Silmitasertib) 50mg
$350.00
In stock
CX-4945 (Silmitasertib) 10mM * 1mL in DMSO
$85.00
In stock
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Adooq Products cited in reputable paper
Adooq's CX-4945 (Silmitasertib) has been cited by 14 publications
  • Michael Ohene-Nyako, .et al. , ASN Neuro, 2023, Jan-Dec;15:17590914231158218 PMID: 36890725
  • Xixi Zhao, .et al. , Cancer Res, 2022, Jun 6;82(11):2185-2195 PMID: 35385574
  • Janeen H. Trembley, .et al. , Biomedicines, 2021, May; 9(5): 571 PMID: 34070147
  • Tianzhi Huang, .et al. , Mol Cell, 2021, Mar 18;81(6):1276-1291 PMID: 33539787
  • M Afzal, .et al. , Molecular and Cellular Biochemistry, 2020, 470, pages131-143
  • Zaman MS, .et al. , Biometals, 2019, Oct 3 PMID: 31583500
  • Fukumoto Y, .et al. , Biochem Biophys Res Commun, 2019, Sep 17;517(2):310-316 PMID: 31353086
  • Fukumoto Y, .et al. , Biochem Biophys Res Commun, 2018, Oct 2;504(2):380-386 PMID: 29902452
  • ST Ribeiro, .et al. , Leukemia, 2017, Jul; 31(7): 1603-1610 PMID: 27899804
  • Valentina Gandin, .et al. , Nat Commun, 2016, 7: 11127 PMID: 27040916
  • Ampofo E, .et al. , Eur Surg Res, 2016, 57(1-2):111-24 PMID: 27287005
  • Emmanuel Ampofo, .et al. , Thromb Res., 2015, Nov;136(5):996-1006 PMID: 26381437
  • Emmanuel Ampofo, .et al. , Biochim Biophys Acta., 2015, Oct;1852(10 Pt A):2123-36 PMID: 26189586
  • A. Margarida Gomes, .et al. , Haematologica, 2014, 99(6): 1062-1068 PMID: 24561792
  • Biological Activity
    Discription CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.
    Targets
    Target Value
    Product Information
    Catalog Num A11060
    Formula C19H12ClN3O2
    Molecular Weight 349.8
    CAS Number 1009820-21-6
    SMILES C1=CC(=CC(=C1)Cl)NC2=C3C=CN=CC3=C4C=CC(=CC4=N2)C(=O)O
    Synonyms Silmitasertib, CX 4945, CX4945
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 14 mg/mL (40.02 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 1% CMC Na 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 28.59 mL 142.94 mL 285.88 mL
    0.5 mM 5.72 mL 28.59 mL 57.18 mL
    1 mM 2.86 mL 14.29 mL 28.59 mL
    5 mM 0.57 mL 2.86 mL 5.72 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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