Stem Cells / Wnt

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  1. Purmorphamine

    Catalog No. A11480
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    Hedgehog signaling activator
    Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. Learn More
  2. U18666A

    Catalog No. A20195
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    cholesterol synthesis/Hedgehog inhibitor
    U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. Learn More
  3. Mebendazole

    Catalog No. A16606
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    Hedgehog inhibitor
    Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor. Learn More
  4. GDC-0449 (Vismodegib)

    Catalog No. A10258
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    Hedgehog antagonist
    GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Learn More
  5. Cyclopamine

    Catalog No. A10249
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    Hedgehog signaling inhibitor
    Cyclopamine is a Smo or hedgehog signaling pathway inhibitor. Learn More
  6. LY2940680 (Taladegib)

    Catalog No. A11048
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    SMO Antagonist
    LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein. Learn More
  7. TAK-441

    Catalog No. A11351
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    Hedgehog inhibitor
    TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor. Learn More
  8. SANT-1

    Catalog No. A13095
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    Sonic hedgehog inhibitor
    SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Learn More
  9. GANT61

    Catalog No. A13252
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    GLI antagonist
    GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. Learn More
  10. GANT 58

    Catalog No. A11442
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    GLI antagonist
    GANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM. Learn More
  11. Hh-Ag1.5

    Catalog No. A12920
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    Hedgehog inhibitor
    Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM. Learn More
  12. JK 184

    Catalog No. A12925
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    Hedgehog inhibitor
    JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Learn More
  13. HhAntag

    Catalog No. A12418
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    HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway. Learn More
  14. MK-4101

    Catalog No. A16111
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    Hedgehog inhibitor
    MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. Learn More
  15. RU-SKI 43

    Catalog No. A16229
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    Hhat inhibitor
    RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. Learn More
  16. HPI-4

    Catalog No. A16349
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    hedgehog inhibitor
    HPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM. Learn More
  17. IWP-3

    Catalog No. A13192
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    Wnt inhibitor
    IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM). Learn More
  18. BML-284 (Wnt agonist 1)

    Catalog No. A15851
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    Wnt agonist 1
    Wnt agonist 1 is a cell-permeable Wnt signaling activator. It nduces beta-catenin and TCF-dependent transcriptional activity with EC50 value of 0.7 uM. Learn More
  19. ETC-159

    Catalog No. A15840
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    Wnt inhibitor
    ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits beta-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM. Learn More
  20. IQ-1

    Catalog No. A16064
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    Wnt/beta-catenin inhibitor
    IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/beta-catenin signaling. Learn More
  21. WAY-262611

    Catalog No. A16094
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    Wnt pathway activator
    WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay. Learn More
  22. CCT251545

    Catalog No. A16216
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    Wnt inhibitor
    CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM. Learn More
  23. Hexachlorophene

    Catalog No. A16217
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    Wnt/beta-catenin inhibitor
    Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 uM; also is an inhibitor of Wnt/beta-catenin signaling. Learn More
  24. JW74

    Catalog No. A16219
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    Wnt inhibitor
    JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM. Learn More
  25. ICG-001

    Catalog No. A11039
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    Wnt/beta-catenin inhibitor
    ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) . Learn More
  26. XAV 939

    Catalog No. A10994
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    PARP inhibitor
    XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively). Learn More
  27. KY02111

    Catalog No. A12362
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    Wnt inhibitor
    KY02111 is a potent and selective Wnt signaling pathway inhibitor discovered by a cell-based screening, which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation. Learn More
  28. LGK-974

    Catalog No. A12816
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    PORCN inhibitor
    LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay. Learn More
  29. IWR-1-endo

    Catalog No. A12737
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    Wnt inhibitor
    IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. Learn More
  30. IWP-2

    Catalog No. A12707
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    Wnt inhibitor
    IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent. Learn More
  31. Wnt-C59

    Catalog No. A12951
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    PORCN/Wnt inhibitor
    Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. Learn More
  32. IWP-L6

    Catalog No. A13978
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    PORCN inhibitor
    IWP-L6 is a potent inhibitor of Porcupine (Porcn), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Learn More
  33. Salinomycin sodium salt

    Catalog No. A15229
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    Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Learn More
  34. PRI-724

    Catalog No. A15856
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    CBP/beta-catenin antagonist

    PRI-724, an isomer or enantiomer of ICG-001 (A11039), is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity.

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  35. Cardiogenol C HCl

    Catalog No. A16198
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    Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 uM. Cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Learn More
  36. KYA1797K

    Catalog No. A16353
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    Wnt/beta-catenin inhibitor
    KYA1797K is a highly potent and selective Wnt/beta-catenin inhibitor with IC50 of 0.75 μM (TOPflash assay). Learn More
  37. iCRT3

    Catalog No. A16847
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    Wnt/β-catenin antagonist
    iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays. Learn More
  38. LF3

    Catalog No. A16851
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    Wnt inhibitor
    LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. Learn More
  39. IWP-4

    Catalog No. A17004
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    Wnt/β-catenin signaling inhibitor
    IWP-4 is a novel potent inhibitor of Wnt/β-catenin signaling. Learn More
  40. pyrvinium

    Catalog No. A17784
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    Wnt inhibitor
    Pyrvinium pamoate is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling. Learn More
  41. Wnt/β-catenin agonist 1

    Catalog No. A18689
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    Wnt/β-catenin agonist
    Wnt/β-catenin agonist 1 is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM. Learn More
  42. HLY78

    Catalog No. A18402
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    Wnt/β-catenin activator
    HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction. Learn More
  43. SKL2001

    Catalog No. A16707
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    Wnt/β-catenin agonist
    SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction. Learn More
  44. Longdaysin

    Catalog No. A21022
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    Wnt/β-catenin signaling inhibitor
    Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Learn More
  45. FH535

    Catalog No. A13795
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  46. WAY-316606

    Catalog No. A13986
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    sFRP-1 inhibitor
    WAY-316606 is a small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Learn More
  47. BC2059

    Catalog No. A14381
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    beta-catenin inhibitor
    BC2059 is an orally bioavailable and potent beta-catenin inhibitor. Learn More
  48. Cardiogenol C hydrochloride

    Catalog No. A15773
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    Cardiogenol C hydrochloride is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm. Learn More
  49. iCRT 14

    Catalog No. A16218
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    CRT inhibitor
    iCRT 14 is a novel potent inhibitor of beta-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Learn More
  50. CX-4945 (Silmitasertib)

    Catalog No. A11060
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    CK2 inhibitor
    CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells. Learn More

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