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Stem Cells/Wnt

Items 1-50 of 183

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Product Name
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Product Information
Product Citation
  1. A10157
    BMS-708163 (Avagacestat)

    Gamma-secretase inhibitor

    BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
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  2. A10199
    CHIR-99021

    GSK-3 Inhibitor

    CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
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  3. A10249
    Cyclopamine

    Hedgehog signaling inhibitor

    Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
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  4. A10258
    GDC-0449 (Vismodegib)

    Hedgehog antagonist

    GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
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  5. A10288
    DAPT (GSI-IX)

    Gamma secretase inhibitor

    DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
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  6. A10344
    Ellagic acid

    Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption.
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  7. A10348
    Emodin

    Emodin is a purgative resin, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica). It belongs to a family of compounds called anthraquinones, which have shown anti-inflammatory and anticancer effects

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  8. A10471
    Indirubin

    CDK & GSK-3β inhibitor

    Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.
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  9. A10802
    RO4929097

    Gamma-secretase inhibitor

    RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
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  10. A10825
    SB 216763

    GSK-3 inhibitor

    SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β).
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  11. A10836
    Semagacestat (LY450139)

    Gamma-secretase inhibitor

    Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
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  12. A10994
    XAV 939

    PARP inhibitor

    XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively).
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  13. A11039
    ICG-001

    Wnt/beta-catenin inhibitor

    ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) .
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  14. A11048
    LY2940680 (Taladegib)

    SMO Antagonist

    LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein.
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  15. A11060
    CX-4945 (Silmitasertib)

    CK2 inhibitor

    CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.
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  16. A11061
    SB 415286

    GSK-3 inhibitor

    SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM.
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  17. A11085
    CHIR-98014

    GSK-3 inhibitor

    CHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3.
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  18. A11174
    YO-01027

    γ-secretase inhibitor

    YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.
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  19. A11176
    LY-411575

    Gamma secretase inhibitor

    LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

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  20. A11194
    MK-0752

    Gamma-secretase inhibitor

    MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
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  21. A11223
    TWS119

    GSK-3 Inhibitor

    TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM.
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  22. A11258
    Begacestat (GSI-953)

    γ-secretase inhibitor

    Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
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  23. A11259
    PF-03084014

    γ-secretase inhibitor

    PF-03084014 is a reversible and selective inhibitor of γ-secretase with IC50 value of 6.2 nM .
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  24. A11337
    BMS 433796

    γ-Secretase Inhibitor

    BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.
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  25. A11351
    TAK-441

    Hedgehog inhibitor

    TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor.
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  26. A11393
    E 2012

    gamma-secretase modulator

    E 2012 is γ-secretase inhibitor.
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  27. A11425
    gamma-secretase modulator 1

    Gamma-secretase modulator

    gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease.
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  28. A11427
    gamma-secretase modulator 2

    Gamma-secretase modulator

    gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease.
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  29. A11442
    GANT 58

    GLI antagonist

    GANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM.
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  30. A11480
    Purmorphamine

    Hedgehog signaling activator

    Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.
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  31. A11592
    Tideglusib

    GSK-3 Inhibitor

    Tideglusib is a GSK-3 inhibitor currently in phase II clinical trials for the treatment of Alzheimer disease and progressive supranuclear palsy
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  32. A11781
    PF 670462

    Casein kinase inhibitor

    Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.
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  33. A11941
    TDZD-8

    GSK-3 Inhibitor

    TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity
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  34. A12362
    KY02111

    Wnt inhibitor

    KY02111 is a potent and selective Wnt signaling pathway inhibitor discovered by a cell-based screening, which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation.
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  35. A12418
    HhAntag

    HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway.
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  36. A12433
    Flurizan

    gamma-secretase modulator

    Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.
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  37. A12444
    BMS 299897

    γ-secretase inhibitor

    BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
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  38. A12491
    MBP146-78

    PKG inhibitor

    MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases.
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  39. A12624
    Casein Kinase II Inhibitor IV

    Epidermal keratinocyte differentiation inducer

    Casein Kinase II Inhibitor IV is a small-molecule inducer of epidermal keratinocyte differentiation.
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  40. A12658
    Verteporfin

    YAP inhibitor

    Verteporfin is a small molecule that inhibits TEAD, YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin.

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  41. A12707
    IWP-2

    Wnt inhibitor

    IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent.
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  42. A12737
    IWR-1-endo

    Wnt inhibitor

    IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.
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  43. A12741
    LY2090314

    GSK-3 inhibitor

    LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis.
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  44. A12774
    LDE225 Diphosphate

    Smoothened Inhibitor

    LDE225 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity.
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  45. A12775
    PF-5274857

    Smoothened Inhibitor

    PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ?? 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ?? 1.4 nmol/L in cells.
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  46. A12816
    LGK-974

    PORCN inhibitor

    LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
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  47. A12819
    AZD1080

    GSK3 inhibitor

    AZD1080 is a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.
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  48. A12920
    Hh-Ag1.5

    Hedgehog inhibitor

    Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM.
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  49. A12925
    JK 184

    Hedgehog inhibitor

    JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM).
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  50. A12951
    Wnt-C59

    PORCN/Wnt inhibitor

    Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.
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