Stem Cells / Wnt

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  1. GDC-0449 (Vismodegib)

    Catalog No. A10258
    Hedgehog antagonist
    GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Learn More
  2. Cyclopamine

    Catalog No. A10249
    Hedgehog signaling inhibitor
    Cyclopamine is a Smo or hedgehog signaling pathway inhibitor. Learn More
  3. LY2940680 (Taladegib)

    Catalog No. A11048
    SMO Antagonist
    LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein. Learn More
  4. TAK-441

    Catalog No. A11351
    Hedgehog inhibitor
    TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor. Learn More
  5. SANT-1

    Catalog No. A13095
    Sonic hedgehog inhibitor
    SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Learn More
  6. GANT61

    Catalog No. A13252
    GLI antagonist
    GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. Learn More
  7. GANT 58

    Catalog No. A11442
    GLI antagonist
    GANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM. Learn More
  8. Hh-Ag1.5

    Catalog No. A12920
    Hedgehog inhibitor
    Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM. Learn More
  9. JK 184

    Catalog No. A12925
    Hedgehog inhibitor
    JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Learn More
  10. HhAntag

    Catalog No. A12418
    HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway. Learn More
  11. MK-4101

    Catalog No. A16111
    Hedgehog inhibitor
    MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. Learn More
  12. RU-SKI 43

    Catalog No. A16229
    Hhat inhibitor
    RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. Learn More
  13. HPI-4

    Catalog No. A16349
    hedgehog inhibitor
    HPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM. Learn More
  14. IWP-3

    Catalog No. A13192
    Wnt inhibitor
    IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM). Learn More
  15. BML-284 (Wnt agonist 1)

    Catalog No. A15851
    Wnt agonist 1
    Wnt agonist 1 is a cell-permeable Wnt signaling activator. It nduces beta-catenin and TCF-dependent transcriptional activity with EC50 value of 0.7 uM. Learn More
  16. ETC-159

    Catalog No. A15840
    Wnt inhibitor
    ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits beta-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM. Learn More
  17. IQ-1

    Catalog No. A16064
    Wnt/beta-catenin inhibitor
    IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/beta-catenin signaling. Learn More
  18. WAY-262611

    Catalog No. A16094
    Wnt pathway activator
    WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay. Learn More
  19. CCT251545

    Catalog No. A16216
    Wnt inhibitor
    CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM. Learn More
  20. Hexachlorophene

    Catalog No. A16217
    Wnt/beta-catenin inhibitor
    Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 uM; also is an inhibitor of Wnt/beta-catenin signaling. Learn More
  21. JW74

    Catalog No. A16219
    Wnt inhibitor
    JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM. Learn More
  22. ICG-001

    Catalog No. A11039
    Wnt/beta-catenin inhibitor
    ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) . Learn More
  23. XAV 939

    Catalog No. A10994
    PARP inhibitor
    XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively). Learn More
  24. KY02111

    Catalog No. A12362
    Wnt inhibitor
    KY02111 is a potent and selective Wnt signaling pathway inhibitor discovered by a cell-based screening, which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation. Learn More
  25. LGK-974

    Catalog No. A12816
    PORCN inhibitor
    LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay. Learn More
  26. IWR-1-endo

    Catalog No. A12737
    Wnt inhibitor
    IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. Learn More
  27. IWP-2

    Catalog No. A12707
    Wnt inhibitor
    IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent. Learn More
  28. Wnt-C59

    Catalog No. A12951
    PORCN/Wnt inhibitor
    Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. Learn More
  29. IWP-L6

    Catalog No. A13978
    PORCN inhibitor
    IWP-L6 is a potent inhibitor of Porcupine (Porcn), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Learn More
  30. Salinomycin sodium salt

    Catalog No. A15229
    Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Learn More
  31. PRI-724

    Catalog No. A15856
    CBP/beta-catenin antagonist

    PRI-724, an isomer or enantiomer of ICG-001 (A11039), is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity.

    Learn More
  32. Cardiogenol C HCl

    Catalog No. A16198
    Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 uM. Cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Learn More
  33. KYA1797K

    Catalog No. A16353
    Wnt/beta-catenin inhibitor
    KYA1797K is a highly potent and selective Wnt/beta-catenin inhibitor with IC50 of 0.75 μM (TOPflash assay). Learn More
  34. iCRT3

    Catalog No. A16847
    Wnt/β-catenin antagonist
    iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays. Learn More
  35. LF3

    Catalog No. A16851
    Wnt inhibitor
    LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. Learn More
  36. IWP-4

    Catalog No. A17004
    Wnt/β-catenin signaling inhibitor
    IWP-4 is a novel potent inhibitor of Wnt/β-catenin signaling. Learn More
  37. WAY-316606

    Catalog No. A13986
    sFRP-1 inhibitor
    WAY-316606 is a small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Learn More
  38. Cardiogenol C hydrochloride is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm. Learn More
  39. iCRT 14

    Catalog No. A16218
    CRT inhibitor
    iCRT 14 is a novel potent inhibitor of beta-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Learn More
  40. CX-4945 (Silmitasertib)

    Catalog No. A11060
    CK2 inhibitor
    CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells. Learn More
  41. LH 846

    Catalog No. A13574
    CK1 inhibitor
    LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α) Learn More
  42. D4476

    Catalog No. A13949
    CK1 Inhibitor
    D4476 is a cell-permeant inhibitor of casein kinase 1. Learn More
  43. TTP-22

    Catalog No. A14101
    CK2 inhibitor
    TTP 22 is a high affinity, casein kinase 2 (CK2) inhibitor (IC50= 0.1uM, Ki= 40nM). In addition, TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 uM). TTP 22 is highly conserved serine/threonine protein kinase that is also involved in cell proliferation, cell differentiation and apoptosis. Learn More
  44. DMAT

    Catalog No. A15069
    CK2 inhibitor
    DMAT is a potent and specific CK2 inhibitor with an IC50 of 0.13 uM. Learn More
  45. TBB

    Catalog No. A15257
    CK2 Inhibitor
    TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 uM for rat liver and human recombinant CK2 respectively). Learn More
  46. IC 261

    Catalog No. A15764
    CK1δ and CK1ε inhibitor
    IC 261 is CK1δ and CK1ε inhibitor. Learn More
  47. CX-4945 sodium salt

    Catalog No. A16234
    CK2 inhibitor
    CX-4945 sodium salt is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2α, respectively. Learn More
  48. SR-3029

    Catalog No. A16235
    CK1δ/CK1ε inhibitor
    SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor with the IC50 of 97 nM. Learn More
  49. TA-01

    Catalog No. A16236
    CK inhibitor
    TA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively). Learn More

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