Everolimus (RAD001)

Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.
Grouped product items
Product Name Price Stock Qty
Everolimus 10mg
$60.00
In stock
Everolimus 50mg
$105.00
In stock
Everolimus 100mg
$135.00
In stock
Everolimus (RAD001) 10mM * 1mL in DMSO
$116.00
In stock
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Adooq Products cited in reputable paper
Adooq's Everolimus (RAD001) has been cited by 9 publications
  • Ming-Chun Hung, .et al. , Cell Biosci, 2022, 12: 122 PMID: 35918763
  • Yusuke Murase, .et al. , Oncol Rep, 2022, Apr;47(4):61 PMID: 35088890
  • Gabriela Torres-Flores, .et al. , Adv Polym Technol, 2020, ID 5462949
  • Takaaki Fujimura, .et al. , Cancer Biol Ther, 2020, Sep 1;21(9):863-870 PMID: 32835580
  • BD Henriksbo, .et al. , Am J Physiol Endocrinol Metab, 2020, Jul 1;319(1):E110-E116 PMID: 32421368
  • Hiroshi Fukamachi, .et al. , J Exp Clin Cancer Res, 2019, 38:127 PMID: 30866995
  • Nachi Namatame, .et al. , Oncotarget, 2018, Oct 12; 9(80): 35141-35161 PMID: 30416685
  • Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Rieko Ohki, .et al. , Proc Natl Acad Sci U S A, 2014, 111(23): E2404-E2413 PMID: 24912192
  • Biological Activity
    Discription Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.
    Targets
    Target Value
    Product Information
    Catalog Num A10374
    Formula C53H83NO14
    Molecular Weight 958.2
    CAS Number 159351-69-6
    SMILES C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC
    Synonyms SDZ-RAD, Certican, Zortress, Afinitor
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 91 mg/mL (94.97 mM)
    Water Insoluble
    Ethanol 6 mg/mL (6.26 mM)
    In vivo 30% Propylene glycol (dissolve first)+5% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 10.44 mL 52.18 mL 104.36 mL
    0.5 mM 2.09 mL 10.44 mL 20.87 mL
    1 mM 1.04 mL 5.22 mL 10.44 mL
    5 mM 0.21 mL 1.04 mL 2.09 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

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      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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      C2

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