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FIPI

PLD inhibitor

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Catalog No. A13895

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
FIPI 10mg A13895-10

Regular Price: $120.00

Special Price: $96.00

FIPI 25mg A13895-25

Regular Price: $250.00

Special Price: $200.00

FIPI 50mg A13895-50

Regular Price: $400.00

Special Price: $320.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Isoforms of phospholipase D (PLD) cleave the head group from phospholipids, releasing the second messenger phosphatidic acid (PA), which can produce changes in Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM).

FIPI

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Chemical Information

Catalog Num A13895
Actions Inhibitor
M. Wt 421.5
Formula C23H24FN5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 939055-18-2
Synonyms 5-Fluoro-2-Indolyl des-Chlorohalopemide
SMILES code C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F
Chemical Name N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride

Biological Activity

Description
Isoforms of phospholipase D (PLD) cleave the head group from phospholipids, releasing the second messenger phosphatidic acid (PA), which can produce changes in Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM).

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