GKT137831
GKT137831 is a first in class inhibitor targeting NOX1 and NOX4 enzymes.
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Adooq Products cited in reputable paper
Adooq's GKT137831 has been cited by 1 publications
- Chia-Hui Huang, .et al. , Toxicol Appl Pharmacol, 2020, Apr 17;397:115013 PMID: 32305283
Biological Activity
| Description | GKT137831 is a first in class inhibitor targeting NOX1 and NOX4 enzymes. | ||
|---|---|---|---|
| Targets |
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Product Information
| Catalog Num | A14433 |
|---|---|
| Formula | C21H19ClN4O2 |
| Molecular Weight | 394.85 |
| CAS Number | 1218942-37-0 |
| SMILES | CN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl |
| Synonyms | GKT-137831, GKT 137831 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | Warmed: 72 mg/mL (182.34 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+2% Tween 80+30% PEG 300+ddH2O | 8 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.33 mL | 126.63 mL | 253.26 mL |
| 0.5 mM | 5.07 mL | 25.33 mL | 50.65 mL |
| 1 mM | 2.53 mL | 12.66 mL | 25.33 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
