Immunology & Inflammation

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  1. Suplatast tosilate

    Catalog No. A10881
    Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM. Learn More
  2. Y320

    Catalog No. A11963
    IL-17 inhibitor
    Y320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM. Learn More
  3. SC-144

    Catalog No. A13660
    gp130 inhibitor
    SC-144 is an orally active small-molecule gp130 inhibitor. Learn More
  4. T cell activator
    beta-Interleukin I (163-171), human, a peptide. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). Learn More
  5. MCC950 sodium

    Catalog No. A13478
    NLRP3 inhibitor
    MCC950 sodium is a potent NLRP3 inflammasome inhibitor that inhibits IL-1beta production with IC50 value of 7.5 nm. Learn More
  6. YM-90709

    Catalog No. A15999
    interleukin-5 receptor antagonist
    YM-90709 is an interleukin-5 receptor antagonist. YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC50 values of 1.0 and 0.57 microM, respectively. Learn More
  7. APY0201

    Catalog No. A16268
    IL-12/23 inhibitor
    APY0201 is a potent and selective IL-12/23 inhibitor. Learn More
  8. AS101

    Catalog No. A16414
    IL-1 inhibitor
    AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. Learn More
  9. Radicicol

    Catalog No. A11768
    Hsp90/SRC/COX-2 Inhibitor
    Radicicol is a potent inhibitor of Hsp90, SRC, and Cox-2 Learn More
  10. Fexofenadine HCl

    Catalog No. A11859
    COX inhibitor/histamine H1 receptor agonist
    Fexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist Learn More
  11. Tepoxalin

    Catalog No. A12879
    COX/5-LOX inhibitor
    Tepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile Learn More
  12. Pranoprofen

    Catalog No. A11641
    COX inhibitor
    Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology Learn More
  13. (-)-Epicatechin

    Catalog No. A12043
    COX-1 inhibitor
    (-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1 Learn More
  14. ATB 346

    Catalog No. A13983
    COX-2 inhibitor
    ATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity. Learn More
  15. Meclofenamate Sodium

    Catalog No. A12520
    COX inhibitor
    Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM. Learn More
  16. Paradol

    Catalog No. A15205
    COX-1 Inhibitor
    Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects Learn More
  17. Etoricoxib

    Catalog No. A13770
    COX-2 inhibitor
    Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. Learn More
  18. Xanthohumol

    Catalog No. A15919
    COX inhibitor
    Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Learn More
  19. SC 560

    Catalog No. A13023
    COX-1 inhibitor
    SC 560 is a COX-1 selective inhibitor, which can be used as a pharmacological tool to study the role of COX-1-derived PGs in inflammation and pain. Learn More
  20. Ibuprofen (Advil)

    Catalog No. A10461
    COX-1 inhibitor
    Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM. Learn More
  21. COX-1 inhibitor
    Ibuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug. Learn More
  22. COX-2 inhibitor
    Asaraldehyde is a selective COX-2 inhibitor. Learn More
  23. Celecoxib

    Catalog No. A10193
    COX-2 inhibitor

    Celecoxib is a sulfa non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.

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  24. Pravadoline (WIN 48098)

    Catalog No. A10749
    COX inhibitor
    Pravadoline (WIN 48,098) is antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX). Learn More
  25. Sulindac (Clinoril)

    Catalog No. A10878
    COX inhibitor
    Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions Learn More
  26. Flunixin meglumine

    Catalog No. A11686
    COX inhibitor
    Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity. Learn More
  27. Acemetacin (Emflex)

    Catalog No. A11692
    COX inhibitor
    Acemetacin is a glycolic acid ester of indometacin. It is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. Learn More
  28. Tolfenamic acid

    Catalog No. A11693
    COX-2 inhibitor
    Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM. It is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine. Learn More
  29. Nimesulide

    Catalog No. A11694
    COX-2 inhibitor
    Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Learn More
  30. Lornoxicam (Xefo)

    Catalog No. A11695
    COX inhibitor
    Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor. It is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. Learn More
  31. Licofelone

    Catalog No. A11697
    COX/LOX inhibitor
    Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. Learn More
  32. Diclofenac sodium

    Catalog No. A10304
    COX inhibitor
    Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. Learn More
  33. ATB-337

    Catalog No. A11986
    ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac Learn More
  34. Rofecoxib (Vioxx)

    Catalog No. A11918
    COX-2 inhibitor
    Rofecoxib (Vioxx) is a?COX-2?inhibitor with?IC5N/A?of 18 nM. Learn More
  35. Phenacetin

    Catalog No. A11906
    Phenacetin is a non-opioid analgesic without anti-inflammatory properties. Learn More
  36. COX inhibitor
    Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling. Learn More
  37. COX inhibitor
    Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Learn More
  38. Piroxicam (Feldene)

    Catalog No. A10736
    COX inhibitor
    Piroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor. Learn More
  39. Iguratimod (T 614)

    Catalog No. A11464
    COX-2 inhibitor
    Iguratimod(T 614) is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity. Iguratimod(T 614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor. Learn More
  40. (S)-(+)-Flurbiprofen

    Catalog No. A12434
    COX inhibitor
    (S)-(+)-Flurbiprofen is a non-selective Cox-1 and Cox-2 inhibitor. Learn More
  41. NS-398

    Catalog No. A13116
    COX-2 inhibitor‎
  42. Bromfenac sodium

    Catalog No. A13244
    COX-2 inhibitor
    Bromfenac sodium is a topically selective cyclooxygenase (COX)-2 inhibitor Learn More
  43. Acetaminophen

    Catalog No. A10030
    COX inhibitor
  44. Naproxen sodium

    Catalog No. A10623
    COX inhibitor
    Naproxen sodium is a non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress. Learn More
  45. FK 3311

    Catalog No. A13332
    COX-2 Inhibitor
    FK3311 is a cell-permeable and orally available sulfonanilide that acts as a selective COX-2 inhibitor and NSAID. Learn More
  46. Valdecoxib

    Catalog No. A13342
    COX-2 inhibitor
  47. Parecoxib

    Catalog No. A13572
    COX-2 inhibitor
    Parecoxib is a potent and selective COX-2 inhibitor. Learn More
  48. Fenbufen

    Catalog No. A16002
    Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. Learn More
  49. Diflunisal

    Catalog No. A16166
    COX inhibitor
    Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. Learn More
  50. Amfenac Sodium Monohydrate

    Catalog No. A16399
    COX inhibitor
    Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively. Learn More

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