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IRAK inhibitor 3
Catalog No. A11457 IL-1 receptor-associated kinase (IRAK) kinase modulatorIRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2. Learn More -
Suplatast tosilate
Catalog No. A10881 Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM. Learn More -
Y320
Catalog No. A11963 IL-17 inhibitorY320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM. Learn More -
SC-144
Catalog No. A13660 gp130 inhibitorSC-144 is an orally active small-molecule gp130 inhibitor. Learn More -
Apilimod
Catalog No. A13794 IL-12/IL-23 inhibitorApilimod is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS?Cstimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. Learn More -
beta-Interleukin I (163-171), human
Catalog No. A15426 T cell activatorbeta-Interleukin I (163-171), human, a peptide. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). Learn More -
MCC950 sodium
Catalog No. A13478 NLRP3 inhibitorMCC950 sodium is a potent NLRP3 inflammasome inhibitor that inhibits IL-1beta production with IC50 value of 7.5 nm. Learn More -
YM-90709
Catalog No. A15999 interleukin-5 receptor antagonistYM-90709 is an interleukin-5 receptor antagonist. YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC50 values of 1.0 and 0.57 microM, respectively. Learn More -
APY0201
Catalog No. A16268 -
AS101
Catalog No. A16414 IL-1 inhibitorAS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. Learn More -
AF 12198
Catalog No. A17213 IL-1 receptor antagonistAF 12198 is a potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor. Learn More -
Radicicol
Catalog No. A11768 Hsp90/SRC/COX-2 InhibitorRadicicol is a potent inhibitor of Hsp90, SRC, and Cox-2 Learn More -
Fexofenadine HCl
Catalog No. A11859 COX inhibitor/histamine H1 receptor agonistFexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist Learn More -
Tepoxalin
Catalog No. A12879 COX/5-LOX inhibitorTepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile Learn More -
Flufenamic acid
Catalog No. A13333 COX inhibitorFlufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels. Learn More -
Pranoprofen
Catalog No. A11641 COX inhibitorPranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology Learn More -
(-)-Epicatechin
Catalog No. A12043 COX-1 inhibitor(-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1 Learn More -
ATB 346
Catalog No. A13983 COX-2 inhibitorATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity. Learn More -
Meclofenamate Sodium
Catalog No. A12520 COX inhibitorMeclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM. Learn More -
Paradol
Catalog No. A15205 COX-1 InhibitorParadol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects Learn More -
Etoricoxib
Catalog No. A13770 COX-2 inhibitorEtoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. Learn More -
Xanthohumol
Catalog No. A15919 COX inhibitorXanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Learn More -
SC 560
Catalog No. A13023 COX-1 inhibitorSC 560 is a COX-1 selective inhibitor, which can be used as a pharmacological tool to study the role of COX-1-derived PGs in inflammation and pain. Learn More -
Etodolac (AY-24236)
Catalog No. A10371 COX inhibitorEtodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM). Learn More -
Tenidap
Catalog No. A13340 COX-1 inhibitorTenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 ?M and 1.2 ?M for COX-1 and COX-2, respectively. Learn More -
GW-406381
Catalog No. A19118 COX-2 inhibitorGW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Learn More -
Eicosatetraynoic acid
Catalog No. A19008 COX/LOX inhibitorEicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 ?M?? Learn More -
Aspirin
Catalog No. A11797 COX-1/COX-2 inhibitorAspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL. Learn More -
Naproxen etemesil
Catalog No. A13052 COX-1 and COX-2 inhibitorNaproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Learn More -
Diclofenac diethylamine
Catalog No. A16503 COX inhibitorDiclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor. Learn More -
Diclofenac
Catalog No. A17814 COX inhibitorDiclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. Learn More -
Etoricoxib D4
Catalog No. A21877 COX-2 inhibitorEtoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. Learn More -
Ibuprofen (Advil)
Catalog No. A10461 COX-1 inhibitorIbuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM. Learn More -
Ibuprofen Lysine (NeoProfen)
Catalog No. A10462 COX-1 inhibitorIbuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug. Learn More -
Asaraldehyde (Asaronaldehyde)
Catalog No. A10090 -
Celecoxib
Catalog No. A10193 COX-2 inhibitorCelecoxib is a sulfa non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.
Learn More -
Pravadoline (WIN 48098)
Catalog No. A10749 COX inhibitorPravadoline (WIN 48,098) is antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX). Learn More -
Sulindac (Clinoril)
Catalog No. A10878 COX inhibitorSulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions Learn More -
Flunixin meglumine
Catalog No. A11686 COX inhibitorFlunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity. Learn More -
Acemetacin (Emflex)
Catalog No. A11692 COX inhibitorAcemetacin is a glycolic acid ester of indometacin. It is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. Learn More -
Tolfenamic acid
Catalog No. A11693 COX-2 inhibitorTolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM. It is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine. Learn More -
Nimesulide
Catalog No. A11694 COX-2 inhibitorNimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Learn More -
Lornoxicam (Xefo)
Catalog No. A11695 COX inhibitorLornoxicam is a non-steroidal COX-1/COX-2 inhibitor. It is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. Learn More -
Licofelone
Catalog No. A11697 COX/LOX inhibitorLicofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. Learn More -
Diclofenac sodium
Catalog No. A10304 COX inhibitorDiclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. Learn More -
ATB-337
Catalog No. A11986 ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac Learn More -
Rofecoxib (Vioxx)
Catalog No. A11918 COX-2 inhibitorRofecoxib (Vioxx) is a COX-2 inhibitor with IC50 of 18 nM. Learn More -
Phenacetin
Catalog No. A11906 Phenacetin is a non-opioid analgesic without anti-inflammatory properties. Learn More -
Indomethacin (Indocid, Indocin)
Catalog No. A10474 COX inhibitorIndomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling. Learn More -
Phenylbutazone (Butazolidin, Butatron)
Catalog No. A10720 COX inhibitorPhenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Learn More
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