Glimepiride

Kir6.2/SUR inhibitor

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Catalog No. A10430

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Glimepiride 500mg A10430-500

Regular Price: $60.00

Special Price: $48.00

Glimepiride 1000mg A10430-1000

Regular Price: $100.00

Special Price: $80.00

Glimepiride 2000mg A10430-2000

Regular Price: $180.00

Special Price: $144.00

Glimepiride 5000mg A10430-5000

Regular Price: $400.00

Special Price: $320.00

Glimepiride 10mM * 1mL in DMSO A10430-10mM-D

Regular Price: $60.00

Special Price: $48.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.

Glimepiride

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Chemical Information

Catalog Num A10430
Actions Inhibitor
M. Wt 490.62
Formula C24H34N4O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 93479-97-1
Synonyms Amary
SMILES code CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
Chemical Name 1-[[p-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]phenyl]sulfonyl]-3-(trans-4-methylcyclohexyl)urea

Biological Activity

Description
Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.
Targets
SUR1 SUR2A SUR2B
3 nM5.4 nM7.3 nM

Solubility

Solubility (25°C)* In vitro DMSO 11 mg/mL (22.42 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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