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GNE 9605

LRRK2 inhibitor

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Catalog No. A14149

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GNE 9605 5mg A14149-5

Regular Price: $120.00

Special Price: $96.00

GNE 9605 10mg A14149-10

Regular Price: $200.00

Special Price: $160.00

GNE 9605 25mg A14149-25

Regular Price: $400.00

Special Price: $320.00

GNE 9605 10mM * 1mL in DMSO A14149-10mM-D

Regular Price: $167.00

Special Price: $133.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively.

GNE 9605

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Chemical Information

Catalog Num A14149
Actions No
M. Wt 449.83
Formula C17H20ClF4N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1536200-31-3
Synonyms GNE-9605,GNE9605
SMILES code CNC1=NC(=NC=C1C(F)(F)F)NC2=C(N(N=C2)[[email protected]]3CCN(C[[email protected]@H]3F)C4COC4)Cl
Chemical Name N2-(5-chloro-1-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine.

Biological Activity

Description
GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively.
Targets
LRRK2 LRRK2
2 nM(Ki)19 nM

Solubility

Solubility (25°C)* In vitro DMSO 89 mg/mL (197.85 mM)
Water <1 mg/mL (<1 mM)
Ethanol 12 mg/mL heating (26.67 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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