GO6983

PKC inhibitor

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Catalog No. A13790

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GO6983 10mg A13790-10
$150.00
GO6983 25mg A13790-25
$300.00
GO6983 50mg A13790-50
$480.00
GO6983 10mM * 1mL in DMSO A13790-10mM-D
$95.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.

GO6983

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Chemical Information

Catalog Num A13790
Actions Inhibitor
M. Wt 442.51
Formula C26H26N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 133053-19-7
Synonyms Go-6983, Go 6983
SMILES code CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
Chemical Name 3-(1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Biological Activity

Description
GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
Targets
Target Value
PKCγIC50: 6nM
PKCαIC50: 7nM
PKCβIC50: 7nM
PKCδIC50: 10nM
PKCζIC50: 60nM
PKCμIC50: 20μM

Solubility

Solubility (25°C) * In vitro DMSO 59 mg/mL (133.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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