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$0.00 TGF-β / Smad
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LY2157299
Catalog No. A11017 TGF-βR InhibitorLY2157299 is an orally active transforming growth factor beta receptor (TGF-βR) kinase inhibitor. Learn More -
SB 431542
Catalog No. A10826 TGF-beta/Smad inhibitorSB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I ALK receptors ALK4, ALK5, and ALK7 . Learn More -
LDN193189
Catalog No. A11205 ALK inhibitorLDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation. Learn More -
LY2109761
Catalog No. A11133 TβRI/II kinase inhibitorLY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis Learn More -
RepSox (SJN 2511)
Catalog No. A11762 RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). Learn More -
DMH-1
Catalog No. A12820 ALK2 inhibitorDMH-1 is a selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM). Learn More -
ITD-1
Catalog No. A12924 TGF-β inhibitorITD-1 is a novel and highly selective TGFβ pathway inhibitor. ITD-1 molecule turns stem cells into heart cells. Learn More -
EW-7197 (Vactosertib)
Catalog No. A14213 ALK4/ALK5 inhibitorEW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively Learn More -
LDN193189 HCl
Catalog No. A11478 LDN193189 HCl is the hydrochloride salt of LDN193189. LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation. Learn More -
SIS3
Catalog No. A16065 Smad3 inhibitorSIS3 is a novel specific inhibitor of Smad3. It has effect on transforming growth factor-beta1-induced extracellular matrix expression. Learn More -
GW788388
Catalog No. A11083 TGF-beta/Smad inhibitorGW788388 is a potent, orally active and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5). Learn More -
SB-505124
Catalog No. A11157 ALK5 inhibitorSB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Learn More -
SB 525334
Catalog No. A10827 ALK InhibitorSB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells Learn More -
Hesperetin
Catalog No. A10449 PDE4 inhibitorHesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer. Learn More -
A 83-01
Catalog No. A12358 TGF-β/ALK5 inhibitorA83-01 is a selective inhibitor of the transforming growth factor-beta type I receptor ALK5, the Nodal receptor ALK4, and the nodal receptor ALK7 Learn More -
LDN-212854
Catalog No. A12821 BMP receptor inhibitorLDN-212854 is an ALK2-Biased BMP Type I Receptor Kinase Inhibitor. Learn More -
Kartogenin
Catalog No. A12926 Smad inhibitorKartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes Learn More -
ML347
Catalog No. A14298 BMP receptor inhibitorML347 is a selective BMP receptor inhibitor . Learn More -
K02288
Catalog No. A14311 BMP inhibitorK02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6. Learn More -
A 77-01
Catalog No. A14436 ALK5 inhibitorA 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. Learn More -
LY364947
Catalog No. A13446 TGFβR-I InhibitorLY364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase). Learn More -
Alantolactone
Catalog No. A14810 Alantolactone, an allergenic sesquiterpene lactone, has recently been found to have significant antitumor effects on malignant tumor cells. Learn More -
NG25
Catalog No. A15185 TAK1/MAP4K2 inhibitorNG25, a TAK1 inhibitor, inhibited the activation of IKK by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells. Learn More -
SB-505124 HCl
Catalog No. A15232 -
SD-208
Catalog No. A14066 TGF-βR InhibitorSD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM); displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Learn More -
(+)-ITD 1
Catalog No. A16073 TGF-β inhibitor(+)-ITD-1 is a resolved enantiomer of ITD-1 that possesses a greater than 2-fold increase in TGF-β inhibition (~400 nM) and 1.3-fold increase in cardiogenesis compared to the racemic ITD-1. Learn More -
LDN-214117
Catalog No. A16096 ALK2 inhibitorLDN-214117 is a selective and potent ALK2 inhibitor. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM. Learn More -
R-268712
Catalog No. A16207 ALK5 inhibitorR-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM. Learn More -
Chebulinic acid
Catalog No. A16208 Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. Learn More -
Pirfenidone
Catalog No. A16209 Pirfenidone is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II. Learn More -
SRI-011381 hydrochloride
Catalog No. A16210 -
LY 3200882
Catalog No. A16816 TGFβRI inhibitorLY 3200882 is a potent, highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion. Learn More -
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New
BIBF0775
Catalog No. A17230 TGFβRI inhibitorBIBF0775 is an inhibitor of the transforming growth factor β receptor I (TGFβRI). Learn More -
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TGFβRI-IN-1
Catalog No. A18800 TGFβRI kinase inhibitorTGFβRI-IN-1 is an oral active and selective TGFβ receptor type I (TGFβRI) kinase inhibitor, with IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively. Learn More -
PKC 412 (Midostaurin)
Catalog No. A12650 PKC inhibitorPKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Learn More -
GO6983
Catalog No. A13790 PKC inhibitorGO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Learn More -
Ro 31-8220 mesylate
Catalog No. A13514 PKC inhibitorRo 31-8220 mesylate is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%. Learn More -
12-O-tetradecanoyl phorbol-13-acetate
Catalog No. A14616 PKC activator12-O-tetradecanoyl phorbol-13-acetate is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. Learn More -
PKC (19-36)
Catalog No. A14871 PKC inhibitorPKC (19-36), pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 uM). Learn More -
(-)-Indolactam V
Catalog No. A13043 PKC activator(-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm. Learn More -
PKC-IN-1
Catalog No. A16212 PKC inhibitorPKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1. Learn More -
NSC305787
Catalog No. A16213 PKC inhibitorNSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 uM, 9.4 uM, 55 uM for PKC phosphorylation of recombinant ezrin, of moesin, and of radixin. Learn More -
Ruboxistaurin (LY333531 HCl)
Catalog No. A16604 PKCβ1 and PKCβ2 inhibitorLY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively. Learn More -
BJE6-106
Catalog No. A18627 PKCδ inhibitorBJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). Learn More -
LXS196
Catalog No. A19419 PKC inhibitorLXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma. Learn More -
PKC-theta inhibitor 1
Catalog No. A18966 PKCθ inhibitorPKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. Learn More -
Roy-Bz
Catalog No. A13348 PKCδ activatorRoy-Bz is a selecive PKCδ activator. Roy-Bz potently inhibits the proliferation of colon cancer cells by inducing a PKCδ-dependent mitochondrial apoptotic pathway involving caspase-3 activation. Learn More -
Delcasertib
Catalog No. A12829 δ-protein kinase C (δPKC) inhibitorDelcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor. Learn More -
DCPLA-ME
Catalog No. A21368 PKCε activatorDCPLA-ME, the methyl ester form of DCPLA, is a potent PKCε activator for use in the treatment of neurodegenerative diseases. Learn More
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