TGF-β / Smad

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    BIBF0775

    Catalog No. A17230
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    TGFβRI inhibitor
    BIBF0775 is an inhibitor of the transforming growth factor β receptor I (TGFβRI). Learn More
  1. K02288

    Catalog No. A14311
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    BMP inhibitor
    K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6. Learn More
  2. A 77-01

    Catalog No. A14436
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    ALK5 inhibitor
    A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. Learn More
  3. LY364947

    Catalog No. A13446
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    TGFβR-I Inhibitor
    LY364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase). Learn More
  4. Alantolactone

    Catalog No. A14810
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    Alantolactone, an allergenic sesquiterpene lactone, has recently been found to have significant antitumor effects on malignant tumor cells. Learn More
  5. NG25

    Catalog No. A15185
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    TAK1/MAP4K2 inhibitor
    NG25, a TAK1 inhibitor, inhibited the activation of IKK by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells. Learn More
  6. SB-505124 HCl

    Catalog No. A15232
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    TGF-β Receptors Inhibitor
    SB-505124 hydrochloride is an inhibitor of activin receptor-like kinases (ALKs). Learn More
  7. SD-208

    Catalog No. A14066
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    TGF-βR Inhibitor
    SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM); displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Learn More
  8. SIS3

    Catalog No. A16065
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    Smad3 inhibitor
    SIS3 is a novel specific inhibitor of Smad3. It has effect on transforming growth factor-beta1-induced extracellular matrix expression. Learn More
  9. (+)-ITD 1

    Catalog No. A16073
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    TGF-β inhibitor
    (+)-ITD-1 is a resolved enantiomer of ITD-1 that possesses a greater than 2-fold increase in TGF-β inhibition (~400 nM) and 1.3-fold increase in cardiogenesis compared to the racemic ITD-1. Learn More
  10. LDN-214117

    Catalog No. A16096
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    ALK2 inhibitor
    LDN-214117 is a selective and potent ALK2 inhibitor. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM. Learn More
  11. R-268712

    Catalog No. A16207
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    ALK5 inhibitor
    R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM. Learn More
  12. Chebulinic acid

    Catalog No. A16208
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    Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. Learn More
  13. Pirfenidone

    Catalog No. A16209
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    Pirfenidone is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II. Learn More
  14. SRI-011381 hydrochloride

    Catalog No. A16210
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    TGF-beta agonist
    SRI-011381 hydrochloride is a TGF-beta signaling agonist. Learn More
  15. LY 3200882

    Catalog No. A16816
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    TGFβRI inhibitor
    LY 3200882 is a potent, highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion. Learn More
  16. ML347

    Catalog No. A14298
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    BMP receptor inhibitor
    ML347 is a selective BMP receptor inhibitor . Learn More
  17. LDN193189 HCl

    Catalog No. A11478
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    LDN193189 HCl is the hydrochloride salt of LDN193189. LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation. Learn More
  18. LY2157299

    Catalog No. A11017
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    TGF-βR Inhibitor
    LY2157299 is an orally active transforming growth factor beta receptor (TGF-βR) kinase inhibitor. Learn More
  19. SB 431542

    Catalog No. A10826
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    TGF-beta/Smad inhibitor
    SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 . Learn More
  20. GW788388

    Catalog No. A11083
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    TGF-beta/Smad inhibitor
    GW788388 is a potent, orally active and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5). Learn More
  21. SB-505124

    Catalog No. A11157
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    ALK5 inhibitor
    SB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Learn More
  22. LDN193189

    Catalog No. A11205
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    ALK inhibitor
    LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation. Learn More
  23. SB 525334

    Catalog No. A10827
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    ALK Inhibitor
    SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells Learn More
  24. LY2109761

    Catalog No. A11133
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    TβRI/II kinase inhibitor
    LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis Learn More
  25. Hesperetin

    Catalog No. A10449
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    PDE4 inhibitor
    Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer. Learn More
  26. RepSox (SJN 2511)

    Catalog No. A11762
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    RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). Learn More
  27. EW-7197

    Catalog No. A14213
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    ALK4/ALK5 inhibitor
    EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively Learn More
  28. F9995-0144

    Catalog No. A14162
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    TGF-beta receptor inhibitor
  29. Kartogenin

    Catalog No. A12926
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    Smad inhibitor
    Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes Learn More
  30. ITD-1

    Catalog No. A12924
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    TGF-β inhibitor
    ITD-1 is a novel and highly selective TGFβ pathway inhibitor. ITD-1 molecule turns stem cells into heart cells. Learn More
  31. LDN-212854

    Catalog No. A12821
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    BMP receptor inhibitor
    LDN-212854 is an ALK2-Biased BMP Type I Receptor Kinase Inhibitor. Learn More
  32. DMH-1

    Catalog No. A12820
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    ALK2 inhibitor
    DMH-1 is a selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM). Learn More
  33. A 83-01

    Catalog No. A12358
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    TGF-β/ALK5 inhibitor
    A83-01 is a selective inhibitor of the transforming growth factor-beta type I receptor ALK5, the Nodal receptor ALK4, and the nodal receptor ALK7 Learn More
  34. NSC305787

    Catalog No. A16213
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    PKC inhibitor
    NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 uM, 9.4 uM, 55 uM for PKC phosphorylation of recombinant ezrin, of moesin, and of radixin. Learn More
  35. PKC-IN-1

    Catalog No. A16212
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    PKC inhibitor
    PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1. Learn More
  36. (-)-Indolactam V

    Catalog No. A13043
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    PKC activator
    (-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm. Learn More
  37. PKC (19-36)

    Catalog No. A14871
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    PKC inhibitor
    PKC (19-36), pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 uM). Learn More
  38. 12-O-tetradecanoyl phorbol-13-acetate

    Catalog No. A14616
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    PKC activator
    12-O-tetradecanoyl phorbol-13-acetate is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. Learn More
  39. Ro 31-8220

    Catalog No. A13514
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    PKC inhibitor
    Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%. Learn More
  40. GO6983

    Catalog No. A13790
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    PKC inhibitor
    GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Learn More
  41. PKC 412 (Midostaurin)

    Catalog No. A12650
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    PKC inhibitor
    PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Learn More
  42. GF 109203X

    Catalog No. A13197
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    PKC inhibitor
    GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Learn More
  43. Verbascoside

    Catalog No. A12014
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    PKC inhibitor
    Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity. Learn More
  44. NH125

    Catalog No. A14307
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    eEF-2 inhibitor
    NH125 is a selective eEF-2 kinase inhibitor. Learn More
  45. Valrubicin

    Catalog No. A14336
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    Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. Learn More
  46. Prostratin

    Catalog No. A13679
    PKC activator
    Prostratin is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans. Learn More
  47. [Ser25] Protein Kinase C (19-31)

    Catalog No. A14882
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    Protein Kinase C (19-31), this peptide derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase C substrate peptide for testing the protein kinase C activity. Learn More
  48. TAS 301

    Catalog No. A15557
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    PKC inhibitor
    TAS 301 is an inhibitor of smooth muscle cell migration and proliferation. Learn More
  49. Ingenol Mebutate (PEP005)

    Catalog No. A12963
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    Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. Learn More

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