GSK-J4

Name: GSK-J4
Brand: Adooq Bioscience
SKU: A12732
Rating: 5 (1 reviews)

Catalog No.: A12732

Demethylase Inhibitor

Adooq's GSK-J4 has been cited by 1 publications

GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF?? release).

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GSK-J4 1373423-53-0 Demethylase Inhibitor

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Grouped product items
Size	Price	Stock
2mg	$45.00	In stock
5mg	$75.00	In stock
10mg	$130.00	In stock
25mg	$200.00	In stock
50mg	$360.00	In stock
100mg	$575.00	In stock
200mg	$730.00	In stock
*10mM 1mL in DMSO**	$135.00	In stock
Bulk Size	Bulk Discount

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Data Sheet SDS

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Adooq Products cited in reputable paper

Adooq's GSK-J4 has been cited by 1 publications

Guang Bai, .et al. , Epigenetics of Chronic Pain, 2019, Pages 1-48

Biological Activity

Description	GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF?? release).

Product Information

Catalog Num	A12732
Formula	C24H27N5O2
Molecular Weight	417.5
CAS Number	1373423-53-0
SMILES	CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4
Synonyms	GSK J4
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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