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Epigenetics



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Catalog No. Product Name Application Product Information
A10611 SALE

MS-275 (Entinostat)

HDAC inhibitor
MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively.
A10947 SALE

Trichostatin-A (TSA)

HDAC Inhibitor
Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.
A10122 SALE

Belinostat (PXD101)

HDAC inhibitor
Belinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM.
A10518 SALE

LBH589 (Panobinostat)

HDAC Inhibitor
LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.
A10560 SALE

MC1568

HDAC Inhibitor
MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis.
A10246 SALE

CUDC-101

HDAC inhibitor
CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.
A10586

MGCD0103 (Mocetinostat)

HDAC Inhibitor
MGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11.
A10979 SALE

Vorinostat (SAHA)

HDAC inhibitor
Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors.
A10488

ITF2357 (Givinostat)

HDAC inhibitor
ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.
A10337 SALE

Droxinostat

HDAC inhibitor
Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively.
A11037

AR-42 (HDAC-42)

HDAC inhibitor
AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.
A10700 SALE

PCI-24781 (Abexinostat)

HDAC Inhibitor
PCI-24781 is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor.
A11042 SALE

Tubastatin A HCl

HDAC6 inhibitor
Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
A10830

SB939 ( Pracinostat )

HDAC inhibitor
SB939 is an oral inhibitor of HDAC, selective for class I, II and IV HDACs and displays an IC50 value of 77 nM in an in vitro HDAC1 activity assay.
A10492 SALE

JNJ-26481585

HDAC inhibitor
JNJ-26481585 is a pan-HDAC inhibitor with marked potency toward HDAC1 (IC(50), 0.16 nmol/L).
A10764 SALE

Pyroxamide (NSC 696085)

HDAC Inhibitor
Pyroxamide (NSC 696085) is a potent inhibitor of affinity-purified HDAC1 and causes the accumulation of acetylated core histones in MEL cells cultured with the agent.
A11152 SALE

PCI-34051

HDAC inhibitor
PCI-34051 is a specific and potent histone deacetylase 8 (HDAC8) inhibitor, with >200-fold selectivity over the other HDAC isoforms.
A11153 SALE

CUDC-907

HDAC inhibitor
CUDC-907 is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.
A10698 SALE

Parthenolide ((-)-Parthenolide)

-
Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium).
A10954

Tubacin

HDAC6 inhibitor
Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM.
A10516 SALE

LAQ824 (NVP-LAQ824, Dacinostat)

HDAC Inhibitor
LAQ824 (NVP-LAQ824) is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.
A11940 SALE

ACY-1215 (Rocilinostat)

HDAC6 inhibitor
ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.
A11964 SALE

CI994 (Tacedinaline)

HDAC Inhibitor
CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells.
A11920 SALE

Romidepsin (FK228 ,Depsipeptide)

HDAC inhibitor
Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.
A12745

Apicidin

HDAC inhibitor
Apicidin is a a potent histone deacetylases (HDAC) inhibitor with potential anticancer activity.
A13218 SALE

RGFP966

HDAC3 inhibitor
RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.
A12911

BRD9757

HDAC6 inhibitor
BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6.
A12556 SALE

Resminostat

HDAC inhibitor
Resminostat, also known as RAS2410, is a potent inhibitor of histone deacetylase (HDAC) classes I and II. It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones.
A12722

Scriptaid

HDAC inhibitor
Scriptaid is an HDAC inhibitor (histone deacetylase).
A14128 SALE

TMP 269

HDAC inhibitor
TMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
A13139

RG2833 (RGFP109)

HDAC inhibitor
RG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3.
A15489 SALE

BRD73954

HDAC inhibitor
BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively).
A15220

Resminostat hydrochloride

HDAC inhibitor
Resminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM.
A15354

KD 5170

HDAC inhibitor
KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.
A15355

NCH 51

HDAC Inhibitor
NCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM.
A15356

NSC 3852

HDAC Inhibitor
NSC 3852 is an HDAC (histone deacetylase) inhibitor.
A12758 SALE

ACY-241

HDAC6 inhibitor
ACY-241 is a new, selective and orally available inhibitor of HDAC6.
A14032

Nexturastat A

HDAC6 inhibitor
Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM).
A14197 SALE

HPOB

HDAC6 inhibitor
HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).
A14221

Splitomicin

NAD(+)-dependent histone deacetylase Sir2p inhibitor
Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 uM, showing a higher activity in a cell-based assay.
A12616 SALE

Tasquinimod

HDAC4 inhibitor
Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling.
A14236

Santacruzamate A

HDAC inhibitor
Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs.
A14341 SALE

LMK-235

HDAC4/5 inhibitor
LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor.
A14418

ST7612AA1

HDAC inhibitor
ST7612AA1 is a new and potent HDAC inhibitor with potential anticancer activity.
A14354 SALE

4SC-202

HDAC inhibitor
4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity.
A14326

TMP 195

HDAC inhibitor
TMP195 is the most potent and selective class IIa HDAC inhibitor.
A15781

UF010

HADC inhibitor
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 uM, 0.1 uM, 0.5 uM and 1.5 uM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.
A13405

HDAC inhibitor

HDAC inhibitor
N/A
A15357

TC-H 106

HDAC inhibitor
TC-H 106 is a slow, tight-binding inhibitor of class I HDACs (histone deacetylases).
A15387

TCS HDAC6 20b

HDAC6 inhibitor
TCS HDAC6 20b, selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol. Also inhibits growth of MCF-7 cells stimulated by estrogen.

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