GSK1838705A ON SALE IGF-1R Inhibitor

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Catalog No. A11175

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GSK1838705A 5mg A11175-5

Regular Price: $90.00

Special Price: $76.50

GSK1838705A 10mg A11175-10

Regular Price: $160.00

Special Price: $136.00

GSK1838705A 50mg A11175-50

Regular Price: $620.00

Special Price: $527.00

GSK1838705A 100mg A11175-100

Regular Price: $1,050.00

Special Price: $892.50

GSK1838705A 10mM * 1mL in DMSO A11175-10mM-D

Regular Price: $155.00

Special Price: $131.75

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.

GSK1838705A

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Chemical Information

Catalog Num A11175
Actions Inhibitor
M. Wt 532.57
Formula C27H29FN8O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1116235-97-2
Synonyms GSK-1838705A
SMILES code CNC(=O)C1=C(C=CC=C1F)NC2=NC(=NC3=C2C=CN3)NC4=C(C=C5CCN(C5=C4)C(=O)CN(C)C)OC
Chemical Name 2-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin-6-ylamino)-7H pyrrolo[2,3-d] pyrimidin-4-ylamino)-6-fluoro-N-methylbenzamide

Biological Activity

Description

GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.

Targets
Target Value
ALKIC50: 0.5nM
Insulin ReceptorIC50: 1.6nM
IGF-1RIC50: 2nM
RSK1IC50: 1.6μM
JNK3IC50: 2μM
B-Raf(V600E)IC50: >2μM
JNK1IC50: 5μM
JAK3IC50: 5μM
JNK2IC50: 8μM
Akt1IC50: >10μM
Akt2IC50: >10μM
ALK5IC50: >10μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
CaMKK2IC50: >10μM
CDK2/CyclinAIC50: >10μM
EGFRIC50: >10μM
ErbB2IC50: >10μM
HGKIC50: >10μM
IKK3IC50: >10μM
PAK1IC50: >10μM
PCTAIRE1IC50: >10μM
PDK-1IC50: >10μM
PI3KαIC50: >10μM
PI3KβIC50: >10μM
PI3KδIC50: >10μM
PI3KγIC50: >10μM
PKCεIC50: >10μM
ROCK1IC50: >10μM
Src1IC50: >10μM
VEGFR2IC50: >10μM
YAK3IC50: >10μM
p70S6KIC50: >10μM
JAK2IC50: 13μM
JAK1IC50: >25μM
ASK1IC50: >25μM
ErbB4IC50: >25μM
GSK-3βIC50: >25μM
IKK1IC50: >25μM
IKK2IC50: >25μM
ITKIC50: >25μM
LCKIC50: >25μM
MAPKAPK2IC50: >25μM
p38αIC50: >25μM
SykIC50: >25μM
ZAP70IC50: >25μM

Solubility

Solubility (25°C) * In vitro DMSO 107 mg/mL (200.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol/citrate vehicle 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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