GSK1838705A

Catalog No.: A11175
IGF-1R Inhibitor

GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.

Grouped product items
Product Name Price Stock Qty
GSK1838705A 5mg
$90.00
In stock
GSK1838705A 10mg
$160.00
In stock
GSK1838705A 50mg
$620.00
In stock
GSK1838705A 100mg
$950.00
In stock
GSK1838705A 10mM * 1mL in DMSO
$155.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's GSK1838705A has been cited by 1 publications
  • Watanabe S, .et al. , Pflugers Arch, 2016, Apr;468(4):667-77 PMID: 26577585
  • Biological Activity
    Discription

    GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.

    Targets
    Target Value
    Product Information
    Catalog Num A11175
    Formula C27H29FN8O3
    Molecular Weight 532.57
    CAS Number 1116235-97-2
    SMILES CNC(=O)C1=C(C=CC=C1F)NC2=NC(=NC3=C2C=CN3)NC4=C(C=C5CCN(C5=C4)C(=O)CN(C)C)OC
    Synonyms GSK-1838705A
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 103 mg/mL (193.4 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 15% Captisol+citrate vehicle 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.78 mL 93.88 mL 187.77 mL
    0.5 mM 3.76 mL 18.78 mL 37.55 mL
    1 mM 1.88 mL 9.39 mL 18.78 mL
    5 mM 0.38 mL 1.88 mL 3.76 mL
    Useful Calculator

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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