Catalog No.
Product Name
Application
Product Information
Product Citation
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IGF-1R inhibitor
GSK1904529A selectively inhibits IGF-IR and IR with IC(50)s of 27 and 25 nmol/L, respectively. -
IGF-1R inhibitor
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.- Kazuya Takayama, .et al. , Sci Rep, 2018, 8: 8278 PMID: 29844341
- Kentaro Hirose, .et al. , BMC Dev Biol, 2014, 14: 42. PMID: 25480380
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IGF-1R inhibitor
NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).- Deep R Sharma, .et al. , Cereb Cortex, 2023, Jan 16 PMID: 36646459
- Ashalyn P Watt, .et al. , Cell Tissue Res, 2021, Jan 13 PMID: 33439347
- Tsushima H, .et al. , Autoimmunity, 2017, Aug;50(5):329-335 PMID: 28682648
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IGF-1R inhibitor
OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).- Masao Kakoki, .et al. , Communications Biology, 2021, 4:775
- Nakamura T, .et al. , J Med Food, 2018, Jul;21(7):701-708 PMID: 29583066
- Tzeng SF, .et al. , FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
- Takata N, .et al. , In Vitro Cell Dev Biol Anim., 2016, May;52(5):607-15 PMID: 26956358
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IGF-1R inhibitor
BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.- Qiao Zhou, .et al. , Onco Targets Ther, 2015, 8: 689-697 PMID: 25897243
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IGF-1R inhibitor
BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.- Li Li, .et al. , Leukemia Res, 2019, 78:12-20 PMID: 30660961
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IGF-1R Inhibitor
GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.
- Watanabe S, .et al. , Pflugers Arch, 2016, Apr;468(4):667-77 PMID: 26577585
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IGF-1R Inhibitor
AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.- Maeda A, .et al. , Mol Nutr Food Res. , 2014, 58(6):1177-89 PMID: 24668740
- Picropodophyllin (AXL1717) is the first targeted oral small-molecule IGF-1 receptor inhibitor with no effect on the insulin receptor.
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IGF-1R, Aurora, FGFR, ABL, SRC inhibitor
XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases. -
IGF1R inhibitor
E 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R. - Gastric Inhibitory Peptide, porcine is a glucose-dependent insulinotropic polypeptide, is a 42 amino acid intestinal hormone with effects on fat and glucose metabolism.
- [D-Ala2]-GIP (human) is a GIP receptor agonist. [D-Ala2]-GIP (human) improves glucose tolerance. [D-Ala2]-GIP (human) shows neuroprotective activity in MPTP-induced Parkinson's disease model. [D-Ala2]-GIP (human) also improves cognitive function and hippocampal synaptic plasticity in obese diabetic rats. [D-Ala2]-GIP (human) can be used for research of type 2 diabetes, Parkinson's disease, etc
