INK 128 (MLN0128)

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mTOR inhibitor

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Catalog No. A11461

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
INK 128 5mg A11461-5

Regular Price: $80.00

Special Price: $68.00

INK 128 10mg A11461-10

Regular Price: $100.00

Special Price: $85.00

INK 128 25mg A11461-25

Regular Price: $180.00

Special Price: $153.00

INK 128 50mg A11461-50

Regular Price: $250.00

Special Price: $212.50

INK 128 10mM * 1mL in DMSO A11461-10mM-D

Regular Price: $80.00

Special Price: $68.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

INK 128 is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.

INK 128 (MLN0128)

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Chemical Information

Catalog Num A11461
Actions Inhibitor
M. Wt 309.3
Formula C15H15N7O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1224844-38-5
Synonyms INK128, INK-128
SMILES code CC(C)N1C2=C(C(=N1)C3=CC4=C(C=C3)OC(=N4)N)C(=NC=N2)N
Chemical Name 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity

Description
INK 128 is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.
Targets
Target Value
mTORki: 1.4nM
mTORki: 1.4nM
PI3KαIC50: 219nM
PI3KγIC50: 221nM
PI3KδIC50: 230nM
PI3KβIC50: 5293nM

Solubility

Solubility (25°C) * In vitro DMSO 62 mg/mL (200.43 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.46 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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