IWP-2

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Wnt inhibitor

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Catalog No. A12707

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
IWP-2 5mg A12707-5

Regular Price: $50.00

Special Price: $42.50

IWP-2 10mg A12707-10

Regular Price: $80.00

Special Price: $68.00

IWP-2 25mg A12707-25

Regular Price: $150.00

Special Price: $127.50

IWP-2 100mg A12707-100

Regular Price: $450.00

Special Price: $382.50

IWP-2 10mM * 1mL in DMSO A12707-10mM-D

Regular Price: $90.00

Special Price: $76.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent.

IWP-2

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Chemical Information

Catalog Num A12707
Actions Inhibitor
M. Wt 466.6
Formula C22H18N4O2S3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 686770-61-6
Synonyms IWP 2,IWP2
SMILES code CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4
Chemical Name N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

Biological Activity

Description
IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent.
Targets
Wnt (Cell-free assay)
27 nM

Solubility

Solubility (25°C)* In vitro DMSO 29 mg/mL (62.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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