LDE225 (NVP-LDE225, Sonidegib)

LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).
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Product Name Price Stock Qty
LDE225 5mg
$50.00
In stock
LDE225 10mg
$70.00
In stock
LDE225 50mg
$150.00
In stock
LDE225 100mg
$250.00
In stock
LDE225 (NVP-LDE225) 10mM * 1mL in DMSO
$50.00
In stock
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Adooq Products cited in reputable paper
Adooq's LDE225 (NVP-LDE225, Sonidegib) has been cited by 1 publications
  • Daniel Doheny, .et al. , Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
  • Biological Activity
    Discription LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).
    Targets
    Target Value
    Product Information
    Catalog Num A10520
    Formula C26H26F3N3O3
    Molecular Weight 485.5
    CAS Number 956697-53-3
    SMILES C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 82 mg/mL (168.89 mM)
    Water Insoluble
    Ethanol Warmed: 82 mg/mL (168.89 mM)
    In vivo 2% DMSO+corn oil 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.6 mL 102.99 mL 205.97 mL
    0.5 mM 4.12 mL 20.6 mL 41.19 mL
    1 mM 2.06 mL 10.3 mL 20.6 mL
    5 mM 0.41 mL 2.06 mL 4.12 mL
    Useful Calculator

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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