LDE225 (NVP-LDE225)

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Smo Antagonist

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Catalog No. A10520

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LDE225 5mg A10520-5

Regular Price: $50.00

Special Price: $42.50

LDE225 10mg A10520-10

Regular Price: $70.00

Special Price: $59.50

LDE225 50mg A10520-50

Regular Price: $150.00

Special Price: $127.50

LDE225 100mg A10520-100

Regular Price: $250.00

Special Price: $212.50

LDE225 (NVP-LDE225) 10mM * 1mL in DMSO A10520-10mM-D

Regular Price: $50.00

Special Price: $42.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).

LDE225 (NVP-LDE225)

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Chemical Information

Catalog Num A10520
Actions Antagonist
M. Wt 485.5
Formula C26H26F3N3O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 956697-53-3
Synonyms LDE-225
SMILES code C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
Chemical Name rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide

Biological Activity

Description
LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).
Targets
Smo (mouse) (Cell-free assay) Smo (human) (Cell-free assay)
1.3 nM2.5 nM

Solubility

Solubility (25°C) * In vitro DMSO 97 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 97 mg/mL (199.79 mM)
In vivo 0.5% CMC 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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