LGK-974

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PORCN inhibitor

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Catalog No. A12816

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LGK-974 5mg A12816-5

Regular Price: $90.00

Special Price: $76.50

LGK-974 10mg A12816-10

Regular Price: $150.00

Special Price: $127.50

LGK-974 25mg A12816-25

Regular Price: $300.00

Special Price: $255.00

LGK-974 50mg A12816-50

Regular Price: $550.00

Special Price: $467.50

LGK-974 10mM * 1mL in DMSO A12816-10mM-D

Regular Price: $186.00

Special Price: $158.10

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.

LGK-974

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Chemical Information

Catalog Num A12816
Actions Inhibitor
M. Wt 396.44
Formula C23H20N6O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1243244-14-5
Synonyms LGK974, LGK 974
SMILES code CC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C
Chemical Name 2-(2',3-dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

Biological Activity

Description
LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
Targets
Porcn (TM3 cells)

Solubility

Solubility (25°C)* In vitro DMSO 79 mg/mL heating (199.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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