Meclizine 2HCl

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Catalog No. A11700

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Meclizine dihydrochloride 10 g A11700-10000
$100.00

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Quick Overview

Meclizine is a human pregnane X receptor (hPXR) agonist. It possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Its antiemetic and antivertigo effects are not fully understood, but its central anticholinergic properties are partially responsible.

Meclizine 2HCl

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Chemical Information

Catalog Num A11700
Actions N/A
M. Wt 463.87
Formula C25H27Cl2N2.2HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1104-22-9
Synonyms Meclozine
SMILES code CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl
Chemical Name 1-[(4-Chlorophenyl)phenylmethyl]4-[ (3-methylphenyl)methyl]piperazine dihydrochloride

Biological Activity

Description
Meclizine is a human pregnane X receptor (hPXR) agonist. It possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Its antiemetic and antivertigo effects are not fully understood, but its central anticholinergic properties are partially responsible.

Solubility

Solubility (25°C) * In vitro DMSO 1 mg/mL (2.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 5% DMSO/95% Corn oil 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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