Endocrinology / Hormones

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  1. Tamoxifen Citrate

    Catalog No. A10885
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    Estrogen receptor antagonist
    Tamoxifen Citrateis a selective and potent inhibitor of mammalian sterol isomerase. Learn More
  2. Elacestrant

    Catalog No. A12244
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    Estrogen receptor degrader
    Elacestrant (RAD1901) is an orally available selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Learn More
  3. Tamoxifen

    Catalog No. A16738
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    selective estrogen receptor modulator (SERM)
    Tamoxifen (ICI 47699) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Learn More
  4. Estetrol

    Catalog No. A21291
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    nuclear estrogen receptor modulator
    Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Learn More
  5. GDC-0927 Racemate

    Catalog No. A21507
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    estrogen receptor degrader
    GDC-0927 Racemate (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. Learn More
  6. Fulvestrant R enantiomer

    Catalog No. A21545
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    estrogen receptor antagonist
    Fulvestrant R enantiomer (ICI 182780 R enantiomer; ZD 9238 R enantiomer; ZM 182780 R enantiomer) is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. Learn More
  7. Pipendoxifene hydrochloride

    Catalog No. A21623
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    estrogen receptor modulators
    Pipendoxifene hydrochloride is a selective estrogen receptor modulators (SERMs). Learn More
  8. H3B-6545 Hydrochloride

    Catalog No. A21629
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    estrogen receptor covalent antagonist
    H3B-6545 Hydrochloride is an oral, selective estrogen receptor covalent antagonist (SERCA). Learn More
  9. AZD9496 maleate

    Catalog No. A21726
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    estrogen receptor (ERα) antagonist
    AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with IC50 of 0.28 nM. AZD9496 maleate is an orally bioavailable selective oestrogen receptor degrader (SERD). Learn More
  10. Enclomiphene citrate

    Catalog No. A21830
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    oestrogen receptor antagonist
    Enclomiphene citrate is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property. Learn More
  11. 4-Hydroxytamoxifen

    Catalog No. A20955
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    estrogen receptor modulator
    4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM). Learn More
  12. TAK-875 (Fasiglifam)

    Catalog No. A11018
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    GPR agonist
    TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist. Learn More
  13. Fulvestrant (Faslodex)

    Catalog No. A10410
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    Aromatase inhibitor
    Fulvestrant is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. Learn More
  14. Dienogest

    Catalog No. A10308
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    Dienogest is an oral progestin that has antiandrogenic activity and as a result can improve androgenic symptoms. Learn More
  15. Kaempferol

    Catalog No. A10495
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    ERRα and ERRγ inverse agonist
    Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway. Learn More
  16. Hexestrol

    Catalog No. A10451
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    Estrogen/progestogen Receptor agonist
    Hexestrol is a carcinogenic synthetic estrogen that inhibits microtubule polymerization and the formation of ribbon structures. It is an inhibitor of lipid peroxidation. Learn More
  17. Evista (Raloxifene HCl)

    Catalog No. A10375
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    Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women. Learn More
  18. GSK1292263

    Catalog No. A10439
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    GPR119 agonist
    GSK-1292263 is a novel GPR119 agonist. Learn More
  19. LY500307

    Catalog No. A10550
    ERβ agonist
    LY500307 is a potent, selective estrogen receptor beta agonist with an EC50 of 0.66 nM. Learn More
  20. Bazedoxifene acetate

    Catalog No. A11665
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    Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). Bazedoxifene acetate significantly prevents bone mass loss at 20 mg/day in healthy postmenopausal women with normal or low bone mineral density. Learn More
  21. Ethisterone

    Catalog No. A11667
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    Ethisterone is a progestogen hormone. Learn More
  22. Clomifene citrate

    Catalog No. A10230
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    Clomifene inhibits estrogen receptors in hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic-Cpituitary-Cadrenal axis. Learn More
  23. Drospirenone

    Catalog No. A10336
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    Drospirenone is a synthetic hormone used in birth control pills. Learn More
  24. GW9508

    Catalog No. A11965
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    GPR40 Inhibitor
    GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ?50 nM) with reduced activity towards family members GRP120 (EC50 ?3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors. Learn More
  25. Mifepristone (Mifeprex)

    Catalog No. A10591
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    Mifepristone, an antioxidant and glucocorticoid receptor antagonist, demonstrates the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes. Learn More
  26. Liquiritigenin

    Catalog No. A12083
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    Liquiritigenin is a plant-derived highly selective estrogen receptor ?? agonist Learn More
  27. Acolbifene (EM 652, SCH57068)

    Catalog No. A12771
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    estrogen receptor modulator
    acolbifene is a substance being studied in the prevention of breast cancer in women at high risk of breast cancer. Acolbifene hydrochloride binds to estrogen receptors in the body and blocks the effects of estrogen in the breast. It is a type of selective estrogen receptor modulator (SERM). Learn More
  28. Zearalenone

    Catalog No. A13740
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    Zearalenone is a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. Learn More
  29. Arzoxifene HCl

    Catalog No. A13292
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    Arzoxifene HCl is the hydrochloride salt of arzoxifene, a synthetic aromatic derivative with anti-estrogenic properties. Arzoxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist. Learn More
  30. XCT 790

    Catalog No. A13299
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    ERRα antagonist/inverse agonist
    XCT 790 is a potent and specific inverse agonist of ERRα. Learn More
  31. Ospemifene

    Catalog No. A14261
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    estrogen receptor modulator
    Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM). Learn More
  32. IRL-2500

    Catalog No. A13638
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    ETBR antagonist
    IRL-2500 is a potent, selective ETBR antagonist. It shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Learn More
  33. Bazedoxifene

    Catalog No. A15019
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    Estrogen modulator
    Bazedoxifene is a third generation selective modulator of estrogen receptor. Learn More
  34. DY131

    Catalog No. A15071
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    ERRβ and ERRγ agonist
    DY131(GSK 9089) is a novel selective agonist of ERRα and ERRβ. Learn More
  35. Toremifene

    Catalog No. A15265
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    Estrogen receptor modulator
    Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Learn More
  36. Endoxifen

    Catalog No. A12639
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    Estrogen receptor antagonist
    Endoxifen is a secondary metabolite of tamoxifen. It is a primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer. Learn More
  37. AZD9496

    Catalog No. A15822
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    estrogen receptor downregulator and antagonist
    AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. Learn More
  38. (E/Z)-4-hydroxy Tamoxifen

    Catalog No. A12532
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    Estrogen receptor antagonist
    (E/Z)-4-hydroxy Tamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Learn More
  39. RAD1901 HCl salt

    Catalog No. A15990
    RAD1901 is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities. Learn More
  40. GDC-0810 (Brilanestrant)

    Catalog No. A15958
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    Estrogen receptor degrader
    Brilanestrant (GDC-0810, ARN-810) is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors. Learn More
  41. Endoxifen E-isomer hydrochloride

    Catalog No. A16343
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    Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). Learn More
  42. GSK4716

    Catalog No. A16956
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    ERRβ & ERRγ Agonist
    GSK4716 is an Estrogen-related receptors ERRβ and ERRγ agonist with minimal activity for ERRα, ERα and ERβ Learn More
  43. (R)-Equol

    Catalog No. A16986
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    Estrogen receptor agonist
    (R)-Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively. Learn More
  44. Lasofoxifene Tartrate

    Catalog No. A18097
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    selective Estrogen receptor modulator
    Lasofoxifene tartrate is a third-generation selective estrogen receptor modulator. Learn More
  45. H3B-6545

    Catalog No. A20100
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    Estrogen receptor antagonist
    H3B-6545 is an oral, selective estrogen receptor covalent antagonist (SERCA). Learn More
  46. PROTAC ERRα ligand 2

    Catalog No. A18939
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    ERRα inverse agonist
    PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM). Learn More
  47. PROTAC ERRα Degrader-1

    Catalog No. A18910
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    ERRα Degrader
    PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. Learn More
  48. PROTAC ER Degrader-3

    Catalog No. A18519
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    PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). Learn More
  49. MK-6913

    Catalog No. A12311
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    Estrogen receptor β agonist
    Tetrahydrofluoroene 52 is a potent and selective estrogen receptor β agonist. Learn More
  50. Asoprisnil

    Catalog No. A19030
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    Progesterone receptor modulator
    Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human. Learn More

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