Endocrinology / Hormones

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  1. TAK-875 (Fasiglifam)

    Catalog No. A11018
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    GPR agonist
    TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist. Learn More
  2. Fulvestrant (Faslodex)

    Catalog No. A10410
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    Aromatase inhibitor
    Fulvestrant is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. Learn More
  3. Dienogest

    Catalog No. A10308
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    Dienogest is an oral progestin that has antiandrogenic activity and as a result can improve androgenic symptoms. Learn More
  4. Kaempferol

    Catalog No. A10495
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    ERRα and ERRγ inverse agonist
    Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway. Learn More
  5. Hexestrol

    Catalog No. A10451
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    Estrogen/progestogen Receptor agonist
    Hexestrol is a carcinogenic synthetic estrogen that inhibits microtubule polymerization and the formation of ribbon structures. It is an inhibitor of lipid peroxidation. Learn More
  6. Evista (Raloxifene HCl)

    Catalog No. A10375
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    Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women. Learn More
  7. GSK1292263

    Catalog No. A10439
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    GPR119 agonist
    GSK-1292263 is a novel GPR119 agonist. Learn More
  8. LY500307

    Catalog No. A10550
    ERβ agonist
    LY500307 is a potent, selective estrogen receptor beta agonist with an EC50 of 0.66 nM. Learn More
  9. Bazedoxifene acetate

    Catalog No. A11665
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    Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). Bazedoxifene acetate significantly prevents bone mass loss at 20 mg/day in healthy postmenopausal women with normal or low bone mineral density. Learn More
  10. Ethisterone

    Catalog No. A11667
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    Ethisterone is a progestogen hormone. Learn More
  11. Clomifene citrate

    Catalog No. A10230
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    Clomifene inhibits estrogen receptors in hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic-Cpituitary-Cadrenal axis. Learn More
  12. Drospirenone

    Catalog No. A10336
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    Drospirenone is a synthetic hormone used in birth control pills. Learn More
  13. GW9508

    Catalog No. A11965
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    GPR40 Inhibitor
    GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ?50 nM) with reduced activity towards family members GRP120 (EC50 ?3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors. Learn More
  14. Mifepristone (Mifeprex)

    Catalog No. A10591
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    Mifepristone, an antioxidant and glucocorticoid receptor antagonist, demonstrates the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes. Learn More
  15. Liquiritigenin

    Catalog No. A12083
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    Liquiritigenin is a plant-derived highly selective estrogen receptor ?? agonist Learn More
  16. Acolbifene (EM 652, SCH57068)

    Catalog No. A12771
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    estrogen receptor modulator
    acolbifene is a substance being studied in the prevention of breast cancer in women at high risk of breast cancer. Acolbifene hydrochloride binds to estrogen receptors in the body and blocks the effects of estrogen in the breast. It is a type of selective estrogen receptor modulator (SERM). Learn More
  17. Zearalenone

    Catalog No. A13740
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    Zearalenone is a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. Learn More
  18. Arzoxifene HCl

    Catalog No. A13292
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    Arzoxifene HCl is the hydrochloride salt of arzoxifene, a synthetic aromatic derivative with anti-estrogenic properties. Arzoxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist. Learn More
  19. XCT 790

    Catalog No. A13299
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    ERRα antagonist/inverse agonist
    XCT 790 is a potent and specific inverse agonist of ERRα. Learn More
  20. Ospemifene

    Catalog No. A14261
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    estrogen receptor modulator
    Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM). Learn More
  21. IRL-2500

    Catalog No. A13638
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    ETBR antagonist
    IRL-2500 is a potent, selective ETBR antagonist. It shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Learn More
  22. Bazedoxifene

    Catalog No. A15019
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    Estrogen modulator
    Bazedoxifene is a third generation selective modulator of estrogen receptor. Learn More
  23. DY131

    Catalog No. A15071
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    ERRβ and ERRγ agonist
    DY131(GSK 9089) is a novel selective agonist of ERRα and ERRβ. Learn More
  24. Toremifene

    Catalog No. A15265
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    Estrogen receptor modulator
    Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Learn More
  25. Endoxifen

    Catalog No. A12639
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    Estrogen receptor antagonist
    Endoxifen is a secondary metabolite of tamoxifen. It is a primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer. Learn More
  26. AZD9496

    Catalog No. A15822
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    estrogen receptor downregulator and antagonist
    AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. Learn More
  27. 4-Hydroxytamoxifen

    Catalog No. A12532
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    Estrogen receptor antagonist
    4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Learn More
  28. RAD1901 HCl salt

    Catalog No. A15990
    SERD/SERM
    RAD1901 is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities. Learn More
  29. GDC-0810 (Brilanestrant)

    Catalog No. A15958
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    Estrogen receptor degrader
    GDC-0810 an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts. Learn More
  30. Endoxifen E-isomer hydrochloride

    Catalog No. A16343
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    Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). Learn More
  31. GSK4716

    Catalog No. A16956
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    ERRβ & ERRγ Agonist
    GSK4716 is an Estrogen-related receptors ERRβ and ERRγ agonist with minimal activity for ERRα, ERα and ERβ Learn More
  32. (R)-Equol

    Catalog No. A16986
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    Estrogen receptor agonist
    (R)-Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively. Learn More
  33. Tamoxifen Citrate

    Catalog No. A10885
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    Estrogen receptor antagonist
    Tamoxifen Citrateis a selective and potent inhibitor of mammalian sterol isomerase. Learn More
  34. Levonorgestrel

    Catalog No. A10529
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    Levonorgestrelis a synthetic progesterone analog; binds to the progesterone receptor (relative binding affinities are < 0.02, 7.5, 17, 58 and 323 % for estrogen receptors, glucocorticoid receptors, mineralocorticoid receptors, androgen receptors and progesterone receptors respectively). Learn More
  35. Megestrol Acetate

    Catalog No. A10563
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    Megestrol Acetate is a progesterone derivative with antineoplastic properties Learn More
  36. Lonaprisan

    Catalog No. A14130
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    progesterone receptor antagonist
    Lonaprisan is an orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity. Learn More
  37. Nestoron

    Catalog No. A15184
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    progesterone receptor agonist
    Nestoron is a 19-norprogesterone derivative and steroidal progestin which is used as a hormonal contraceptive; a high-affinity agonist of the progesterone receptor. Learn More
  38. Tanaproget

    Catalog No. A15256
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    Progesterone receptor agonist
    Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins. Learn More
  39. ACT-129968 (Setipiprant)

    Catalog No. A15780
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    CRTH2 antagonist
    ACT-129968 is a potent and selective CRTH2 antagonist. Learn More
  40. 17-Hydroxyprogesterone

    Catalog No. A15860
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    17-Hydroxyprogesterone is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens. Learn More
  41. Medroxyprogesterone Acetate

    Catalog No. A11625
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    progesterone receptor agonist
    Medroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist. Learn More
  42. Etonogestrel

    Catalog No. A16117
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    Etonogestrel is a steroidal progestin used in hormonal contraceptives, most notably the subdermal implant Nexplanon and the vaginal ring NuvaRing. Learn More
  43. Hydroxyprogesterone caproate

    Catalog No. A16143
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    Hydroxyprogesterone caproate is a synthetic, steroidal progestin; an ester derivative of 17?α-hydroxyprogesterone formed from caproic acid. Learn More
  44. Desogestrel

    Catalog No. A16173
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    Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. Learn More
  45. MK-0773

    Catalog No. A15164
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    Androgen receptor modulator
    MK-0773, one of selective androgen receptor modulators (SARMs), is a 4-aza-steroid that exhibited tissue selectivity in humans (IC50= 6.6 nM). Learn More
  46. ODM-201

    Catalog No. A15797
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    Androgen receptor antagonist
    ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells. Learn More
  47. EPI-001

    Catalog No. A15814
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    Androgen Receptor antagonist
    EPI-001 is an antagonist of the androgen receptor (AR) that acts by binding covalently to the N-terminal domain (NTD) of the AR and blocking protein-protein interactions required for transcriptional activity of the AR and its splice variants (IC50 for inhibition of AR NTD transactivation ?? 6 μM) Learn More
  48. Flutamide

    Catalog No. A10402
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    Androgen receptor antagonist
    Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer. Learn More
  49. Ostarine (MK-2866, GTx-024)

    Catalog No. A10253
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    Androgen Receptor Modulators
    Ostarine is an androgen receptor modulator (SARM) Learn More
  50. MDV3100

    Catalog No. A10562
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    Androgen receptor antagonist
    MDV3100 is androgen-receptor inhibitor. Highly recommended inhibitor in AR research. Learn More

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